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Bladder urothelium in PBS/IC shows distinct differences in keratin profiles

Research groups from the Netherlands and Denmark led by Pilar Laguna studied urothelial involvement in PBS/IC by characterizing the keratin phenotype of bladder urothelium in 18 patients with the disorder.

20 Aug 2006

Renal transplantation in children with posterior uUrethral valves

The first description of posterior urethral valves (PUV) was made more than 80 years ago by Hugh Hampton Young and represents a spectrum of severity, ranging from disease incompatible with postnatal life to minimal symptoms that may not manifest until later in life.

17 Aug 2006

Elite suppressors of HIV to change how scientists monitor spread of disease

Scientists at Johns Hopkins have found that 1 percent to 2 percent of those infected with HIV in Baltimore apparently suppress the virus to nearly undetectable levels on their own, confounding public health efforts to accurately monitor the pandemic's spread, now in its 20th year.

15 Aug 2006

Cancer stem cells spur glioma angiogenesis, could hold key to brain tumor therapy

Stem cell-like glioma cancer cells that share many characteristics with normal stem cells propel the lethal growth of brain cancers by promoting tumor blood vessel formation, and may hold the key to treating these deadly cancers.

15 Aug 2006

Researchers find precise location where an antibody binds to the West Nile virus

Researchers have learned the precise location where an antibody binds to the West Nile virus, and they have suggested a mechanism for how this antibody neutralizes the virus to prevent infection.

14 Aug 2006

Better understanding of intravenous immunoglobulin

For years, researchers have struggled to understand how IVIG worked. It's ability to treat autoimmune diseases seemed to bean apparent contradiction.

3 Aug 2006

Toxoplasma may be affecting human behavior on a mass scale

A common parasite found in cats may be affecting human behavior on a mass scale, according to a scientist based at the University of California, Santa Barbara.

3 Aug 2006

Protein CD86 raises antibody output

Cancer immunologists here have discovered how a protein on the surface of antibody-making immune cells boosts the amount of antibody the cells make.

2 Aug 2006

Researchers determine why gene therapy treatment caused leukemia in some X-linked severe combined immunodeficiency patients

Scientists at St. Jude Children's Research Hospital have developed a mouse model of a severe disease of the immune system that helps explain why gene therapy used to treat children with this disease at an institution in Europe caused some of them to develop leukemia.

2 Aug 2006

New therapeutics for cancer

A team of scientists at the University of Liverpool has secured the services of the National Biomanufacturing Centre (NBC) to develop and manufacture antibodies against a novel cancer antigen.

1 Aug 2006

Anti-obesity vaccine keeps rats trim

Researchers at the Scripps Research Institute in California in the U.S. have developed an anti-obesity vaccine that significantly slowed weight gain and reduced body fat in rats even when they over ate.

1 Aug 2006

HHS to stockpile Anthrax immune globulin

The Department of Health and Human Services (HHS) has announced it will purchase 10,000 therapeutic courses of treatment of Anthrax Immune Globulin (AIG) from Cangene Corporation of Winnipeg, Manitoba, Canada for a total of $143,833,719.

30 Jul 2006

Vaccination with irradiated Listeria induced protective T cell immunity

Vaccines made with bacteria killed by gamma irradiation, rather than by standard methods of heat or chemical inactivation, may be more effective, say researchers.

26 Jul 2006

GSK reports significant advance in H5N1 pandemic flu vaccine programme

GlaxoSmithKline (GSK) today announced headline data showing that its H5N1 pandemic flu vaccine achieved a high immune response at a low dose of antigen.

26 Jul 2006

Interaction of proteins in the intestinal system may be allergic indicators

Researchers have identified one of the proteins that may be responsible for causing food allergies, which could lead to the development of more accurate non-invasive tests to identify true food allergies.

25 Jul 2006

First study to demonstrate IVIg effective longer than a year

A purified mixture of human antibodies called intravenous immunoglobulin (IVIg) provides lasting benefits to patients with Alzheimer's disease (AD), according to researchers at the NewYork-Presbyterian Hospital/Weill Cornell Medical Center.

25 Jul 2006

Antibodies show promise in treating Alzheimer's

Researchers say infusing human antibodies into people with Alzheimer's disease appears to help stop the disease from getting worse and may even help the patients improve.

19 Jul 2006

Herceptin-linked nanoparticles for targeted cancer therapy

Albumin nanoparticles have recently proven their mettle as anticancer agents with the 2005 approval of Abraxane to treat metastatic breast cancer.

17 Jul 2006

Potential permanent genetic cure for hemophilia A

A discovery by Medical College of Wisconsin and BloodCenter of Wisconsin researchers in Milwaukee may be a key to a permanent genetic cure for hemophilia A patients, including a subset who do not respond to conventional blood transfusions.

3 Jul 2006

Buckyballs deliver multiple drugs simultaneously to tumors

Combining a monoclonal antibody known to target melanoma tumors with multiple C60 buckyballs, researchers at Rice University and the University of Texas M. D. Anderson Cancer Center have developed a new way to deliver multiple drugs simultaneously to tumors.

3 Jul 2006