Atherosclerosis News and Research

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Atherosclerosis is the progressive buildup of plaque - the fatty deposits and other cells - in the inner walls of the arteries. The condition is a consequence of elevated cholesterol and for many it's a silent disease, with no visible signs or symptoms. The disease can begin in early adulthood and continues to progress for the rest of a person's life. Despite the serious nature of atherosclerosis, many people do not understand how it develops and progresses.

Digoxin drug can help protect against atherosclerosis

New research in mice provides convincing evidence that digoxin, a drug prescribed to treat atrial fibrillation, can help protect against atherosclerosis.

17 Feb 2016

Hypertensive women with highly active jobs at higher risk of developing ischaemic heart disease

Hypertensive women with highly active jobs have a nearly three times higher risk of ischaemic heart disease than women with normal blood pressure and moderately active jobs, according to research published today in the European Journal of Preventive Cardiology.

15 Feb 2016

Discovery opens door to preventing diet-induced heart disease

Four years ago, Stanley Hazen, MD, PhD, Chair of Cellular and Molecular Medicine, and colleagues made a landmark discovery linking intestinal bacteria to heart disease. His team found that when our digestive systems digest the nutrients carnitine and choline (abundant in red meat and eggs, respectively), a bacterial waste product called TMAO is formed. They showed that high levels of TMAO are associated with higher rates of heart attack, stroke and cardiac death.

14 Feb 2016

University of Louisville researcher reveals potentially harmful effects of e-cigarettes

While e-cigarette use is increasing worldwide, little is known about the health effects e-cigarettes pose for users. A University of Louisville researcher is working to change that status.

12 Feb 2016

Study sheds light on role of red raspberries in metabolically-based chronic diseases

Components in red raspberries may have anti-inflammatory, anti-oxidative and metabolic stabilizing activity, according to a comprehensive review of the available scientific literature published in the January issue of Advances in Nutrition.

10 Feb 2016

LMU researchers identify new drug target for atherosclerosis

The enzyme Dicer processes RNA transcripts, cutting them into short segments that regulate the synthesis of specific proteins. An Ludwig-Maximilians-Universitaet in Munich team has shown that Dicer promotes the development of atherosclerosis, thus identifying a new drug target.

10 Feb 2016

African-American patients with connective tissue diseases at risk for cardiovascular disease

A study based on medical records from more than a quarter million adult patients found that African-American patients with connective tissue diseases such as lupus or rheumatoid arthritis were twice as likely as white patients to suffer from narrowed or atherosclerotic blood vessels, which increase the risk of a heart attack, stroke or death.

5 Feb 2016

LMU researchers reveal how crystalline deposits induce cell death

Crystal formation plays a defining role in the pathogenesis of a range of common diseases, such as gout and atherosclerosis. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers led by Hans-Joachim Anders have now elucidated how the insoluble deposits induce cell death.

29 Jan 2016

$Parathyroid hormone may mediate antihypertensive fracture risk$

Parathyroid hormone may mediate antihypertensive fracture risk

Parathyroid hormone levels may be elevated by use of some antihypertensive agents but reduced by others, analysis of the Multi-Ethnic Study of Atherosclerosis suggests.

22 Jan 2016

Cardiovascular considerations crucial for CML TKI patients

A review of BCR–ABL1 tyrosine kinase inhibitors highlights the need to consider cardiovascular adverse event risk profiles when prescribing for patients with chronic myeloid leukaemia.

22 Jan 2016

Levels of mitochondrial DNA in the blood may predict chronic kidney disease risk

The health of blood cells' energy-producing mitochondria may predict a person's risk of developing chronic kidney disease (CKD), according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology.

22 Jan 2016

Amgen announces approval of cholesterol-lowering medication Repatha (evolocumab) Injection in Japan

Amgen today announced that the Japanese Ministry of Health, Labour and Welfare has approved the cholesterol-lowering medication Repatha (evolocumab) Injection, the first proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor to be approved in Japan.

22 Jan 2016

Aged Garlic Extract beneficial for preventing heart disease

The supplement Aged Garlic Extract can reverse the buildup of deadly plaque in arteries and help prevent the progression of heart disease, according to a new study scheduled for publication in the Journal of Nutrition.

22 Jan 2016

Bradycardia does not increase cardiovascular disease risk

Bradycardia - a slower than normal heartbeat - does not increase the risk of developing cardiovascular disease, according to a study conducted by researchers at Wake Forest Baptist Medical Center. The study is published in the Jan.19 online edition of the Journal of American Medical Association Internal Medicine.

19 Jan 2016

Mount Sinai Heart starts TANSNIP-PESA study to determine how workplace-based lifestyle intervention reduces CV risk

World-renowned cardiologist Valentin Fuster, MD, PhD, Director of Mount Sinai Heart and Physician-in-Chief of The Mount Sinai Hospital, is undertaking a three-year study, known as the TANSNIP-PESA study, to determine whether a workplace-based lifestyle intervention, accompanied by imaging data, will lead to a reduction in the prevalence of cardiovascular (CV) disease risk factors related to lifestyle.

19 Jan 2016

PK molecule could be a target for vascular complications linked to type 1 diabetes

In an article published ahead of print on November 24, 2015 in the journal Diabetes (available at http://dx.doi.org/10.2337/db15-0930), researchers from the Medical University of South Carolina, the American University of Beirut, and Case Western Reserve University report that a molecule called pre-kallikrein (PK) could be a target for the vascular complications associated with type 1 diabetes.

18 Jan 2016

UT Southwestern pediatric researchers identify key trigger of neonatal lung disease

Pediatric researchers at UT Southwestern Medical Center have identified a key component of the pathogenesis of bronchopulmonary dysplasia (BPD), a devastating and sometimes fatal lung disease that affects premature infants. Their findings clarify what prompts the inflammatory response that results in BPD, which previously had been unclear.

18 Jan 2016

Novel anti-inflammatory agents could control hyper-inflammatory responses to fungal infection

The most frequent fungal threat to humans, Candida albicans, is a common cause oral and genital infection. The fungal infections are often worsened by overwhelming inflammatory responses in the body and cause high mortality among risk groups. Umeå University doctoral student Ava Hosseinzadeh has discovered two novel anti-inflammatory agents, an antioxidant and an anti-inflammatory molecule, which could be used to control the hyper-inflammatory responses to the fungal infection.

12 Jan 2016

AngioDefender holds much promise for personalized cardiac care

For a non-descript box it wields a mighty name and even more impressive possibilities for people with heart disease. Called the AngioDefender, the machine - no bigger than a shoebox - holds much promise in the ability to personalize cardiac care, say researchers at Lawson Health Research Institute, the research arm of St. Joseph's Health Care London.

8 Jan 2016

Infusing small dose of cytokine can prevent or reverse diabetes-related kidney failure

Diabetes is the leading cause of kidney failure, and scientists have found that infusing just a small dose of a cytokine, thought to help cause that failure, can instead prevent or reverse it.

29 Dec 2015

Atherosclerosis News and Research

Further Reading

Digoxin drug can help protect against atherosclerosis

Hypertensive women with highly active jobs at higher risk of developing ischaemic heart disease

Discovery opens door to preventing diet-induced heart disease

University of Louisville researcher reveals potentially harmful effects of e-cigarettes

Study sheds light on role of red raspberries in metabolically-based chronic diseases

LMU researchers identify new drug target for atherosclerosis

African-American patients with connective tissue diseases at risk for cardiovascular disease

LMU researchers reveal how crystalline deposits induce cell death

Parathyroid hormone may mediate antihypertensive fracture risk

Cardiovascular considerations crucial for CML TKI patients

Levels of mitochondrial DNA in the blood may predict chronic kidney disease risk

Amgen announces approval of cholesterol-lowering medication Repatha (evolocumab) Injection in Japan

Aged Garlic Extract beneficial for preventing heart disease

Bradycardia does not increase cardiovascular disease risk

Mount Sinai Heart starts TANSNIP-PESA study to determine how workplace-based lifestyle intervention reduces CV risk

PK molecule could be a target for vascular complications linked to type 1 diabetes

UT Southwestern pediatric researchers identify key trigger of neonatal lung disease

Novel anti-inflammatory agents could control hyper-inflammatory responses to fungal infection

AngioDefender holds much promise for personalized cardiac care

Infusing small dose of cytokine can prevent or reverse diabetes-related kidney failure

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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