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Study reveals variability in polygenic risk scores for predicting heart disease

Polygenic risk scores (PRSs) are a cutting-edge tool in genetics, combining information from genetic markers across the genome to estimate a person's risk of developing certain diseases, such as coronary artery disease (CAD).

19 Nov 2024

From crude lysate to purity with high-precision AAV capsid measurement with Bio-Rad's new ddPCR Kit

Accurately quantify AAV capsids directly from crude lysates with Bio-Rad's new ddPCR kit—offering reliable, efficient, and precise measurement to streamline your research workflows.

From Bio-Rad Laboratories 19 Nov 2024

Multiple sclerosis drug could help individuals with reduced working memory

Fampridine is currently used to improve walking ability in multiple sclerosis. A new study shows that it could also help individuals with reduced working memory, as seen in mental health conditions like schizophrenia or depression.

19 Nov 2024

Innovative platform helps explore genetic links to 99 diseases

A new study introduces the Proteome-Wide Association Study Hub, an innovative and powerful tool designed to explore gene-disease connections across ninety-nine common diseases.

18 Nov 2024

Study uncovers key mechanism behind HIV latency

An immune response that likely evolved to help fight infections appears to be the mechanism that drives human immunodeficiency virus (HIV) into a latent state, lurking in cells only to erupt anew, researchers at Duke Health report.

18 Nov 2024

Rare variant analysis reveals genetic spectrum of monogenic diabetes genes

This study links rare genetic variants to type 2 diabetes risk, emphasizing their role in monogenic diabetes and potential for precision medicine integration.

18 Nov 2024

Neoantigen DNA vaccines improve survival and immunity in triple-negative breast cancer patients

A new phase 1 trial demonstrates the safety and effectiveness of personalized neoantigen DNA vaccines, showing promising immune responses and improved recurrence-free survival in high-risk triple-negative breast cancer patients.

17 Nov 2024

Researchers discover how mutations disrupt protein splicing and cause disease

An international research team has uncovered a new mechanism crucial to the production of cellular proteins.

15 Nov 2024

Genomic surveillance could revolutionize the fight against antimicrobial resistance

During the COVID-19 pandemic, genomic surveillance proved vital in helping understand the evolution and spread of the SARS-CoV-2 virus.

15 Nov 2024

Evo model set to transform synthetic biology and disease diagnosis

A new study presents "Evo" – a machine learning model capable of decoding and designing DNA, RNA, and protein sequences, from molecular to genome scale, with unparalleled accuracy. Evo's ability to predict, generate, and engineer entire genomic sequences could change the way synthetic biology is done.

15 Nov 2024

Researchers discover mechanism affecting splicing process in retinal cells

Genes contain the essential building instructions for life, guiding cells on which amino acids to assemble in what sequence to produce specific proteins. The human genome codes for about 20,000 such instructions.

15 Nov 2024

Researchers use cerebrospinal fluid to unlock pathways in Alzheimer's disease

A multitude of genes have been linked to the development of Alzheimer's disease. Specifically how those genes might influence the progression of neurodegeneration remains something of a black box though, in part because of the challenges of examining in molecular detail the brain of a living patient.

14 Nov 2024