Mutation News and Research

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Researchers demonstrate targeted epigenome editing in the promoter region of several genes using sgRNA/dCas9 complexes

Researchers develop and characterize a highly specific EpiEditing system using catalytically inactivated catalytically inactivated Cas9.

17 Jul 2023

The hidden factors of resistance: how pathogen diversity drives antibiotic response

Researchers aimed to understand the role of within-host microbial diversity on antimicrobial resistance.

14 Jul 2023

Study uncovers pathogenic variants in the chromatin modifier EZH1 as the cause of neurodevelopmental disorders

Study identified pathogenic variants in the EZH1 as a cause of neurodevelopmental disorders.

14 Jul 2023

Combination therapy shows promise in treating advanced ER+ breast cancer

Advanced estrogen receptor-positive (ER+) breast cancer can be especially difficult to treat. A new study by researchers at Dartmouth Cancer Center led by Todd W. Miller, PhD, shows promise in using a combination of estrogen and a PARP inhibitor (a drug that suppresses DNA damage repair), to treat this type of cancer.

13 Jul 2023

Cryo-EM reveals structure of key enzyme involved in protein production

Transfer RNAs (tRNAs) are among the most common types of RNA in a cell and are indispensable for protein production in all known organisms.

13 Jul 2023

New study reveals how lung tumors develop drug resistance

Cancer therapies that target specific genetic abnormalities in tumors have revolutionized treatment possibilities over the past two decades.

13 Jul 2023

New precision medicine trial shows promise for treating rare brain tumors

Papillary craniopharyngiomas (PCPs) are a rare type of brain tumor that cause substantial morbidity for patients.

13 Jul 2023

Pembrolizumab combination therapies effective for advanced NSCLC, study shows

While pembrolizumab is an approved treatment for patients with stage III non-small cell lung cancer (NSCLC), only some patients respond to this therapy. Treatment failure, researchers say, is often caused by differences in the tumor microenvironment.

12 Jul 2023

Study provides a transformational new insight into emergence of antimicrobial resistance

A research study led by the University of Oxford provides a transformational new insight into how antimicrobial resistance (AMR) emerges in patients with bacterial infections.

12 Jul 2023

Scientists identify signal essential for blood-brain barrier formation

What makes the vital layer of protective cells around the brain and spinal cord - the blood-brain barrier - more or less permeable has been one of the more mystifying questions in neuroscience.

12 Jul 2023

New porcine model could help develop treatments for Dduchenne muscular dystrophy

The group of LMU scientist Eckhard Wolf has developed a porcine DMD model with a mutation, which mimics the hallmarks of the human disease but develops them in an accelerated mode.

12 Jul 2023

Many patients with Lynch syndrome remain undiagnosed, study finds

New research from Cedars-Sinai Cancer investigators could warrant reconsideration of current screening guidelines to include a poorly recognized cause of Lynch syndrome, the most common cause of hereditary colorectal and endometrial cancers.

11 Jul 2023

Mouse model of Hutchinson-Gilford progeria syndrome shows reduction in hepatic H2S levels

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 12, entitled, "Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndrome."

11 Jul 2023

Mutation News and Research

Researchers demonstrate targeted epigenome editing in the promoter region of several genes using sgRNA/dCas9 complexes

The hidden factors of resistance: how pathogen diversity drives antibiotic response

Study uncovers pathogenic variants in the chromatin modifier EZH1 as the cause of neurodevelopmental disorders

Combination therapy shows promise in treating advanced ER+ breast cancer

Cryo-EM reveals structure of key enzyme involved in protein production

New study reveals how lung tumors develop drug resistance

New precision medicine trial shows promise for treating rare brain tumors

Pembrolizumab combination therapies effective for advanced NSCLC, study shows

Study provides a transformational new insight into emergence of antimicrobial resistance

Scientists identify signal essential for blood-brain barrier formation

New porcine model could help develop treatments for Dduchenne muscular dystrophy

Many patients with Lynch syndrome remain undiagnosed, study finds

Mouse model of Hutchinson-Gilford progeria syndrome shows reduction in hepatic H2S levels

Novel protein modifies the cellular machinery responsible for producing cellulose in plant cells

The genetics of neurogenic inflammation in rosacea

Scientists investigate a bat virus with pandemic potential

New research sheds light on role of progesterone in breast cancer

New technique could help identify rare genetic disorders while preserving privacy

FOUR PAWS highlights World Zoonoses Day 2023 and outbreak of Highly Pathogenic Avian Influenza

Study traces the natural evolution of earliest stages of human cancers

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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