Immune System News and Research

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Researchers describe central role of mTOR in ageing and age-related diseases

For some, TOR may bring to mind a Celtic mountain or perhaps an Internet privacy group. In the world of molecular biology it's a cellular pathway that's found in everything from yeast to mammals.

18 Aug 2015

NCI-MATCH phase II precision medicine trial opens through ECOG-ACRIN

The National Cancer Institute-Molecular Analysis for Therapy Choice (NCI-MATCH) phase II precision medicine trial, known to doctors as trial EAY131, is open through the ECOG-ACRIN Cancer Research Group.

18 Aug 2015

U-M microbiome research may lead to new ways to prevent, fight lung infections in patients

With every breath you take, microbes have a chance of making it into your lungs. But what happens when they get there? And why do dangerous lung infections like pneumonia happen in some people, but not others? Researchers at the University of Michigan Medical School have started to answer these questions by studying the microbiome of the lungs - the community of microscopic organisms that are in constant contact with our respiratory system.

18 Aug 2015

Regulation of tumor microenvironment may offer alternate method for cancer treatment

Scientists know that activation of growth factor receptors like epidermal growth factor receptors (EGFR) promote tumor progression in many types of cancer.

18 Aug 2015

Tips for preventing ticks, Lyme disease

When a mosquito decides to dine on your blood, you typically know it - there's pain, itch, and annoyance. Ticks, on the other hand, take a stealthier approach, burrowing into hard-to-spot areas and hanging around for hours or days at a time.

14 Aug 2015

Ontario nearing ambitious UN targets for ending AIDS epidemics

A new study suggests Ontario is nearing ambitious United Nations targets for ending the AIDS epidemics: By 2020, 90 per cent of all people living with HIV should know their HIV status, 90 per cent of all people diagnosed with HIV are receiving sustained antiretroviral drug therapy and 90 per cent of people on ART have a very low or undetectable levels of the virus.

14 Aug 2015

Researchers develop new genomic data set on Lassa virus

An international team of researchers has developed the largest genomic data set in the world on Lassa virus (LASV).

14 Aug 2015

PHIV children may lack immunity against measles, mumps, and rubella despite vaccination

Between one-third and one-half of individuals in the United States who were infected with HIV around the time of birth may not have sufficient immunity to ward off measles, mumps, and rubella--even though they may have been vaccinated against these diseases.

14 Aug 2015

Organ transplant recipients more likely to develop melanoma

Organ transplant recipients are twice as likely to develop melanoma as people who do not undergo a transplant, and three times more likely to die of the dangerous skin cancer, suggests new research led by a Johns Hopkins Bloomberg School of Public Health student.

14 Aug 2015

TSRI study reveals ancient roots of Lassa virus and how it has changed over time

Working as part of an international team in North America and West Africa, a researcher at The Scripps Research Institute has published new findings showing the ancient roots of the deadly Lassa virus, a relative of Ebola virus, and how Lassa virus has changed over time.

14 Aug 2015

Merck, MD Anderson form strategic clinical research collaboration to evaluate anti-PD-1 therapy

Merck and The University of Texas MD Anderson Cancer Center announced a strategic clinical research collaboration to evaluate Merck's anti-PD-1 therapy, KEYTRUDA (pembrolizumab), in combination with other treatments, such as chemotherapy, radiation therapy and/or novel anti-tumor medicines.

14 Aug 2015

Combination of chemotherapy and immune-blocking drug could prevent cancer recurrence

Giving patients a drug that blocks part of the immune system from going into overdrive might help prevent cancer coming back in some people, according to research published today in Cancer Research.

13 Aug 2015

Scientists reveal how non-allergenic pollen mediators can increase allergic reactions

Scientists at Helmholtz Zentrum München and TU München discovered a new mechanism how non-allergenic pollen mediators can enhance allergic reactions. Especially the so-called B cells play a critical role in this process. The results were recently published in the Journal 'Allergy' and might lead to new approaches for therapies.

13 Aug 2015

New study explains why statins are more beneficial than others in some cases

Statins' success in reducing atherosclerosis-related events has elevated the medications to wonder-drug status, with some researchers advocating for their wider use as a preemptive therapy for cardiovascular disease.

13 Aug 2015

Researchers identify potential drug target to fight TB

The U.S. Food and Drug Administration recently approved the first new drug to fight tuberculosis (TB) in more than 40 years, but treatment still takes six months, 200 pills and leaves 40 percent of patients uncured. Thus, new targets are needed. Today in ACS Central Science, researchers report they have identified one such target -- a gene that allows the disease to camp out in human immune cells, and is thus essential for the organism's proliferation.

13 Aug 2015

First clinical trial to test use of retinal progenitor cells for treating retinitis pigmentosa begins

Participants are being enrolled in the first clinical trial that tests the use of retinal progenitor cells to treat retinitis pigmentosa, reported project director Dr. Henry Klassen of UCI's Gavin Herbert Eye Institute and Sue & Bill Gross Stem Cell Research Center. The product of stem cell research at UCI, these retinal progenitors are similar to stem cells in terms of potential regenerative properties, but they're specific to the retina.

13 Aug 2015

Researchers develop user-friendly platform for analyzing transcriptomic and epigenomic big data

Researchers at Cincinnati Children's Hospital Medical Center have developed a user-friendly, integrated platform for analyzing the transcriptomic and epigenomic "big data."

12 Aug 2015

Risk of hepatobiliary cancer higher in women with intrahepatic cholestasis of pregnancy

In a new study of more than 125,000 pregnant women in Sweden, researchers at the Sahlgrenska Academy found that the risk of hepatobiliary cancer and immune-mediated and cardiovascular diseases later in life is higher in women with intrahepatic cholestasis of pregnancy (ICP) than in women without this condition.

12 Aug 2015

New study reveals role of hydrogen sulfide gas in autoimmune disease

The immune system not only responds to infections and other potentially problematic abnormalities in the body, it also contains a built-in brake in the form of regulatory T cells, or Tregs. Tregs ensure that inflammatory responses don't get out of hand and do damage. In autoimmune diseases, sometimes these Treg cells don't act as they should.

12 Aug 2015

Scientists identify molecular pathway that can contribute to vision loss in macular degeneration

Scientists have identified a pathway that leads to the formation of atypical blood vessels that can cause blindness in people with age-related macular degeneration.

12 Aug 2015

Immune System News and Research

Researchers describe central role of mTOR in ageing and age-related diseases

NCI-MATCH phase II precision medicine trial opens through ECOG-ACRIN

U-M microbiome research may lead to new ways to prevent, fight lung infections in patients

Regulation of tumor microenvironment may offer alternate method for cancer treatment

Tips for preventing ticks, Lyme disease

Ontario nearing ambitious UN targets for ending AIDS epidemics

Researchers develop new genomic data set on Lassa virus

PHIV children may lack immunity against measles, mumps, and rubella despite vaccination

Organ transplant recipients more likely to develop melanoma

TSRI study reveals ancient roots of Lassa virus and how it has changed over time

Merck, MD Anderson form strategic clinical research collaboration to evaluate anti-PD-1 therapy

Combination of chemotherapy and immune-blocking drug could prevent cancer recurrence

Scientists reveal how non-allergenic pollen mediators can increase allergic reactions

New study explains why statins are more beneficial than others in some cases

Researchers identify potential drug target to fight TB

First clinical trial to test use of retinal progenitor cells for treating retinitis pigmentosa begins

Researchers develop user-friendly platform for analyzing transcriptomic and epigenomic big data

Risk of hepatobiliary cancer higher in women with intrahepatic cholestasis of pregnancy

New study reveals role of hydrogen sulfide gas in autoimmune disease

Scientists identify molecular pathway that can contribute to vision loss in macular degeneration

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