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Engineered SARS-CoV-2 immunogens elicit broadly neutralizing antibodies

New research describes a novel approach whereby SARS-2 antigens were analyzed for conserved sites that may be targeted by broadly neutralizing antibodies that will confer immunity to other Sarbecoviruses.

10 Mar 2022

Quantification of hydrophobic interactions encoded by FP1 sequences of SARS-CoV-2 and MERS-CoV by single-molecule force measurements

Researchers quantified hydrophobic interactions encoded by fusion peptide 1 sequences of SARS-CoV-2 and MERS-CoV using single-molecule force measurements.

10 Mar 2022

Study isolated largest panel of β-CoV broadly neutralizing antibodies to date

Researchers isolated a large panel of broadly neutralizing antibodies from COVID-19 recovered-vaccinated donors.

10 Mar 2022

The trajectory of B-cell immunity six months after mRNA vaccination

Researchers assess SARS-CoV-2 antibodies in individuals vaccinated with a mRNA COVID-19 vaccine six months after receiving their second dose.

10 Mar 2022

'Post-apoptotic pro-metastatic cells' appear to be potential metastasis prevention targets

Researchers at UNIGE show that the experience of impending cell death within a primary tumor can lead to the development of pro-metastatic cells.

10 Mar 2022

Anti-Müllerian hormone plays an active role in polycystic ovary syndrome

High levels of anti-Mullerian hormone (AMH) have traditionally been thought of as merely a passive byproduct of polycystic ovary syndrome (PCOS), but a new preclinical study by Weill Cornell Medicine researchers suggests that the hormone plays an active role in the disorder and may contribute to problems with ovulation and fertility.

10 Mar 2022

Study provides insights into how early life events can affect brain wiring patterns

A new study of brain development in mice shortly after birth may provide insights into how early life events can affect wiring patterns in the brain that manifest as disease later in life – specifically such disorders as schizophrenia, epilepsy and autism.

10 Mar 2022

Active compound in Chinese herbs prevents colon cancer in mice

The active compound in Chinese herbs called emodin can prevent colon cancer in mice, according to researchers at the University of South Carolina School of Medicine.

9 Mar 2022

Researchers exploit cancer cells' appetite for iron to treat tough tumors

Researchers at the University of California, San Francisco, have successfully leveraged an FDA-approved drug to halt growth of tumors driven by mutations in the RAS gene, which are famously difficult to treat and account for about one in four cancer deaths.

9 Mar 2022

NCCN publishes new resources for treating rare tumor types

The National Comprehensive Cancer Network - an alliance of leading cancer centers - today announced the publication of new NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Ampullary Adenocarcinoma.

9 Mar 2022

Cedars-Sinai scientists identify potential new therapy for COVID-19

Investigators at Cedars-Sinai have identified a potential new therapy for COVID-19: a biologic substance created by reengineered human skin cells.

9 Mar 2022

Causal links between severe COVID-19 and blood proteins identified via proteome-wide Mendelian randomization in new study

A recent study was based on Mendelian randomization analyses conducted between high levels of numerous blood proteins and COVID-19.

9 Mar 2022

Mechanical stress of confined migration makes cancer cells more aggressive

Squeezing through tight spaces makes cancer cells more aggressive and helps them evade cell death, shows a study published today in eLife.

9 Mar 2022

Single protein elicits multilineage reprogramming of astrocytes in adult mouse brains

A single protein can reverse the developmental clock on adult brain cells called astrocytes, morphing them into stem-like cells that produce neurons and other cell types, UT Southwestern researchers report in a PNAS study.

9 Mar 2022

The relationship between highly conserved residues in the SARS CoV fusion peptide and their role in coordinating calcium binding for viral entry

Researchers evidenced the significance of calcium in mediating the interaction between the coronaviruses fusion peptide and host cell membrane to provide insights into the mechanisms of viral entry.

9 Mar 2022

B Cell News and Research

Engineered SARS-CoV-2 immunogens elicit broadly neutralizing antibodies

Quantification of hydrophobic interactions encoded by FP1 sequences of SARS-CoV-2 and MERS-CoV by single-molecule force measurements

Study isolated largest panel of β-CoV broadly neutralizing antibodies to date

The trajectory of B-cell immunity six months after mRNA vaccination

'Post-apoptotic pro-metastatic cells' appear to be potential metastasis prevention targets

Anti-Müllerian hormone plays an active role in polycystic ovary syndrome

Study provides insights into how early life events can affect brain wiring patterns

Active compound in Chinese herbs prevents colon cancer in mice

Researchers exploit cancer cells' appetite for iron to treat tough tumors

NCCN publishes new resources for treating rare tumor types

Cedars-Sinai scientists identify potential new therapy for COVID-19

Causal links between severe COVID-19 and blood proteins identified via proteome-wide Mendelian randomization in new study

Mechanical stress of confined migration makes cancer cells more aggressive

Single protein elicits multilineage reprogramming of astrocytes in adult mouse brains

The relationship between highly conserved residues in the SARS CoV fusion peptide and their role in coordinating calcium binding for viral entry

High prevalence of new-onset diabetes with ketoacidosis observed in children during COVID-19 pandemic

CRIPSR identifies cell-type-specific ACE2 modifiers

Low SARS-CoV-2 diabetogenicity found in infected human pancreatic cells in vitro

Mathematical model for evaluating factors driving SARS-CoV-2 transmission and pathogenesis

Intragenomic rearrangements help explain how SARS-CoV-2 variants arise

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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