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Noncovalent protease inhibitors against SARS-CoV-2 and other coronaviruses

In a new study published in ACS Infectious Diseases journal, scientists biochemically and structurally evaluated the PLpro from a subgroup 2b bat coronavirus, BtSCoV-Rf1.2004, to identify unique structural features or enzymatic biases of the subgroup 2b.

28 Feb 2022

Will Omicron BA.2 become the next dominant variant?

A new study presents a comprehensive analysis of the potential of both Omicron BA.2 and BA.3 to become the next dominant circulating SARS-CoV-2 strain.

27 Feb 2022

Emergence of SARS-CoV-2 Omicron likely due to immune selective pressure

A new study discusses the emergence of new variants of SARS-CoV-2 that can escape antibody-mediated neutralization, as opposed to other Sarbecoviruses.

27 Feb 2022

Mechanism behind how certain osmolytes cause kidney damage revealed

Researchers from Tokyo Metropolitan University have uncovered the mechanism by which osmolytes used to treat high fluid pressure in the eye and skull can cause kidney damage.

27 Feb 2022

Altered microbiomes in SARS-CoV-2 infection pose threat of antibiotic resistance

A new study discusses changes in the microbiota of various parts of the body with SARS-CoV-2 infection.

27 Feb 2022

A promising new vaccine for SARS-CoV-2 and influenza

Researchers create a vaccine candidate that could protect against both SARS-CoV-2 and IAVs.

27 Feb 2022

Harvard’s new kidney engineering technology licensed to San Diego-based Trestle Biotherapeutics

A newly launched startup is building upon innovations developed over several years at the Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard John A. Paulson School of Engineering & Applied Sciences (SEAS), and Brigham and Women’s Hospital (Brigham) to engineer functional kidney tissue for renal repair and replacement therapy.

25 Feb 2022

Unexpected discovery could open the door to new treatment for small-cell lung cancer

An unexpected discovery at UVA Cancer Center has allowed scientists to halt the development of small-cell lung cancer in lab mice, and the surprise finding could open the door to a new treatment approach in people.

25 Feb 2022

Spectacular structure of C.difficile's protective armor revealed

The spectacular structure of the protective armor of superbug C.difficile has been revealed for the first time showing the close-knit yet flexible outer layer – like chain mail.

25 Feb 2022

LJI researchers discover new genes in CD4+ "helper" T cell subsets

T cells play important roles in helping to fight infections and cancers - and they can also drive autoimmune diseases. Now researchers at La Jolla Institute for Immunology (LJI) have discovered new genes in CD4+ "helper" T cell subset that are linked to risk of autoimmune diseases.

25 Feb 2022

Targeting a specific protein can help prevent or delay prostate cancer progression

Targeting a specific protein that is often overexpressed in prostate cancer can help prevent or delay the disease from spreading to other parts of the body, according to a study led by Cedars-Sinai Cancer investigators.

25 Feb 2022

Treatment with Tumor Treating Fields triggers downstream anti-tumor cell response, study finds

Novocure announced that a new study published in the Journal of Clinical Investigation (JCI) finds treatment with Tumor Treating Fields (TTFields) mediated cell disruption activates the immune system and triggers an anti-tumor cell response that may be effectively used together with existing immunotherapy approaches in the treatment of solid tumors, with limited systemic toxicity.

25 Feb 2022

Protective immunity signatures provided by convalescent plasma for the development of COVID-19 antibody therapeutics

Researchers conducted a comprehensive and systematic analysis of functional SARS-CoV-2 antibody profiles in a controlled randomized trial of severe COVID-19 hospitalized individuals treated with COVID-19 CCP.

25 Feb 2022

Severe COVID-19 outcomes in breakthrough infections in patients being treated with B cell depleting therapy

Scientists evaluated the incidence and severity of breakthrough SARS-CoV-2 infections among individuals with immune-mediated inflammatory diseases undergoing B cell depleting therapy.

25 Feb 2022

Traditional Chinese medicine can be an effective radiosensitizer for patients with nasopharyngeal carcinoma

Treatment of nasopharyngeal carcinoma (NPC), a group of cancers that originate in the nose and throat, is made complicated by their unique position. Radiation therapy is often the main curative treatment for NPC. However, some patients are resistant to radiation therapy.

25 Feb 2022

B Cell News and Research

Noncovalent protease inhibitors against SARS-CoV-2 and other coronaviruses

Will Omicron BA.2 become the next dominant variant?

Emergence of SARS-CoV-2 Omicron likely due to immune selective pressure

Mechanism behind how certain osmolytes cause kidney damage revealed

Altered microbiomes in SARS-CoV-2 infection pose threat of antibiotic resistance

A promising new vaccine for SARS-CoV-2 and influenza

Harvard’s new kidney engineering technology licensed to San Diego-based Trestle Biotherapeutics

Unexpected discovery could open the door to new treatment for small-cell lung cancer

Spectacular structure of C.difficile's protective armor revealed

LJI researchers discover new genes in CD4+ "helper" T cell subsets

Targeting a specific protein can help prevent or delay prostate cancer progression

Treatment with Tumor Treating Fields triggers downstream anti-tumor cell response, study finds

Protective immunity signatures provided by convalescent plasma for the development of COVID-19 antibody therapeutics

Severe COVID-19 outcomes in breakthrough infections in patients being treated with B cell depleting therapy

Traditional Chinese medicine can be an effective radiosensitizer for patients with nasopharyngeal carcinoma

Declining immune responses against SARS-CoV-2 variants in dialysis patients post-vaccination

T cell responses in inflammatory bowel disease patients on immune-modifying agents after mRNA COVID-19 vaccination

Study uses 3D cervical organoids to show the danger of multiple infections

Osteoblast-derived vesicles regulate the switch from bone formation to resorption via a miRNA-mediated mechanism

New prototype sensor aids in the rapid assessment of disease severity

Immunology eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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