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Scientists engineer new protein that prevents HIV virus entry into cells

In what could be a potential breakthrough in the battle against AIDS and a major development in the rational design of new drugs, scientists have engineered a new protein that prevents the virus from entering cells.

1 Apr 2011

New research finds HIV virus's V3 loop as attractive vaccine target

A section of the AIDS virus's protein envelope once considered an improbable target for a vaccine now appears to be one of the most promising, new research by Dana-Farber Cancer Institute scientists indicates.

1 Apr 2011

Study: Pseudokinases can play a crucial role in pathogen-based disease

Researchers from the University of Pittsburgh and Stanford University discovered that a supposedly inactive protein actually plays a crucial role in the ability of one the world's most prolific pathogens to cause disease, findings that suggest the possible role of similarly errant proteins in other diseases.

1 Apr 2011

CorMedix reports encouraging interim results from CRMD001 phase II study in Contrast Induced Acute Kidney Injury

CorMedix Inc., a pharmaceutical company focused on developing and commercializing therapeutic products for the prevention and treatment of cardiorenal disease, today announced its interim analysis and clinical update for CRMD001.

1 Apr 2011

New signaling pathway discovery sheds light on chronic dermatitis

A new signaling pathway, which is important for the regulation of the immune response and inflammation, was discovered by an international team of scientists led by prof Ivan Dikic from the Goethe University, Frankfurt, Germany.

1 Apr 2011

Positive results from Intercept OCA Phase II trial in patients with PBC

Intercept Pharmaceuticals, Inc., today announced positive results from a 59 patient, placebo controlled, double-blind Phase II clinical trial of obeticholic acid given as monotherapy to patients with primary biliary cirrhosis.

1 Apr 2011

Immune therapy can control fertility in mammals

Researchers at Weill Cornell Medical College have shown that it is possible to immunize mammals to control fertility. They say their technique could possibly be used on other mammals -- including humans -- because fertility hormones and their receptors are species-non-specific and are similar in both females and males. For pets, the technique could be an alternative to castration and adverse effects of hormone administration.

31 Mar 2011

Micro-RNAs appear to play a key role in new mechanism underlying obesity

Max Planck researchers have discovered a new mechanism that leads to the development of type 2 diabetes in obesity. Body weight influences the risk of developing diabetes: between 80 and 90 percent of patients with type 2 diabetes are overweight or obese.

31 Mar 2011

Researchers characterize novel form of ubiquitin regulatory protein

Researchers at the Proteome Center Tuebingen characterize a novel form of the regulatory protein ubiquitin, involved in inflammation and cell death.

31 Mar 2011

Towards accurate simulation of whole working cells

Researchers have built a computer model of the crowded interior of a bacterial cell that - in a test of its response to sugar in its environment - accurately simulates the behavior of living cells.

31 Mar 2011

Study finds frequent anaemia in patients with chronic respiratory failure

A study of nearly 600 patients with severe non-inflammatory respiratory disease has found that a significant percentage also suffered from anaemia, according to the April issue of IJCP, the International Journal of Clinical Practice.

31 Mar 2011

Two new studies on cancer

Last year, a research team at the University of North Carolina at Chapel Hill discovered one way the protein Tet 1 helps stem cells keep their pluripotency-the unique ability to become any cell type in the body.

31 Mar 2011

Basic Yellow 1 dye extends lifespan in healthy nematodes, slows Alzheimer's disease-like pathology in worms

Basic Yellow 1, a dye used in neuroscience laboratories around the world to detect damaged protein in Alzheimer's disease, is a wonder drug for nematode worms. In a study appearing in the March 30, online edition of Nature, the dye, also known as Thioflavin T, (ThT) extended lifespan in healthy nematode worms by more than 50 percent and slowed the disease process in worms bred to mimic aspects of Alzheimer's.

31 Mar 2011

Candy consumption can help reduce weight and risk of CVD

Good news for candy and chocolate lovers: they tend to weigh less, have lower body mass indices and waist circumferences, and have decreased levels of risk factors for cardiovascular disease and metabolic syndrome, according to a new study published in Nutrition Research.

31 Mar 2011

First transdisciplinary research center dedicated to identify causes of premature birth

The March of Dimes and Stanford University School of Medicine today launched the nation's first transdisciplinary research center dedicated to identifying the causes of premature birth. Prematurity is the number one reason for newborn death in the United States today, yet in nearly half of the cases of premature birth, there is no identifiable cause.

31 Mar 2011

Immunotec, NSU to conduct new research study in children with autism

Nova Southeastern University and the dietary supplement company Immunotec announced today that they will conduct a new research study to determine the effects of a supplement to improve behaviors in children with Autism Spectrum Disorder.

31 Mar 2011

Higher protein diets associated with greater feelings of fullness during weight loss

Dieters trying to stick to their diets may want to look no further than lean protein, according to two studies published in the prestigious journal Obesity. Including protein such as lean pork in three daily meals could reduce late-night desires to eat, increase feelings of fullness and decrease distracting thoughts about food, according to the research.

31 Mar 2011

Essential protein linked to TNF induced inflammation

SCIENTISTS have discovered an essential protein that controls inflammation induced by 'tumour necrosis factor' (TNF) - an important part of the body's defences against infection and a driver of cancer-associated inflammation, according to research published in Nature today (Wednesday).

31 Mar 2011

SLN to present Atu027 Phase I study data against solid cancer at ASCO Annual Meeting

Silence Therapeutics plc a leading global RNA interference therapeutics company, announces that interim data from its ongoing Phase I clinical study of Atu027, the Company's lead internal therapeutic candidate, have been accepted for poster presentation at the 2011 American Society of Clinical Oncology Annual Meeting.

30 Mar 2011

Attacks by specific type of immune cells cause inflammations of heart muscle

Scientists of the German Cancer Research Center, jointly with colleagues in the United States, have found out that inflammations of the heart muscle are caused by attacks of a specific type of immune cells. These immune cells attack the body's own tissue because during their maturation they did not have the chance to develop tolerance against a protein that is only found in the heart muscle.

30 Mar 2011