Cell Death News and Research

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Study may pave way for new treatment strategies to limit the progression of solid tumors

Researchers at the University of British Columbia's faculty of medicine and BC Cancer Research Institute have uncovered a weakness in a key enzyme that solid tumour cancer cells rely on to adapt and survive when oxygen levels are low.

28 Aug 2021

Adding berzosertib to standard treatment for metastatic urothelial cancer does not extend patient survival

A Phase 2 trial led by City of Hope, a world-renowned research and treatment center for cancer and diabetes, suggests that adding the novel ataxia telangiectasia and Rad3-related (ATR) inhibitor drug berzosertib to standard-of-care chemotherapy for patients with metastatic urothelial cancer does not extend progression-free survival.

27 Aug 2021

Stiffening of heart’s blood vessels associated with lack of enzyme that fosters cell ‘chatter’

In a study in mice, Johns Hopkins Medicine researchers have found that the smooth muscle cells lining the walls of blood vessels can lose their elasticity and lead to vascular stiffening, a condition that can precede heart disease and stroke.

26 Aug 2021

Study unravels widespread tumor suppression mechanism that halts cancer metastasis

According to a study by The Wistar Institute, the tumor suppressor Parkin, whose levels are reduced in different cancer types, causes acute metabolic and oxidative stress, suppresses mitochondrial trafficking, and blocks tumor cell movement, reducing primary and metastatic tumor growth.

26 Aug 2021

Two studies on gastrointestinal stroma tumors describe advances that may lead to new treatments

Gastrointestinal stroma tumors (GIST) are cancers that start in specialized nerve cells found in the digestive system, from the esophagus and stomach to the intestines and rectum.

25 Aug 2021

Study suggests a novel therapeutic target to reverse lung fibrosis

Researchers have reversed lung fibrosis in a mouse model of idiopathic pulmonary fibrosis, or IPF, as reported in a study published in the journal Cell Death and Differentiation.

24 Aug 2021

New study identifies novel compound as promising pan-coronavirus drug candidate

A recent study describes a novel compound with frameshifting capability against MERS-CoV, inhibiting viral propagation within infected cells.

23 Aug 2021

Study identifies the cause and treatment for rare rheumatoid-like autoinflammatory condition

The absence of a protein that activates the body's antiviral defenses can cause a rare rheumatoid-like autoinflammatory condition that is treatable with an FDA-approved class of drugs known as TNF (tumor necrosis factor) inhibitors, a global research team led by Mount Sinai has found.

19 Aug 2021

Simple roundworm may hold the key to understanding cell death processes

A biologist at The University of Texas at Arlington hopes that a simple roundworm might hold the key to understanding novel cell death processes. Such knowledge could lead to improved therapies to treat a variety of conditions in humans, including cancer and neurological injuries.

14 Aug 2021

Specific leukemia gene mutations exert divergent effects on DNA repair and sensitivity to PARP Inhibitors

In a recent study published in Cancer Research, researchers from Fels Cancer Institute for Personalized Medicine at the Lewis Katz School of Medicine at Temple University and Fox Chase Cancer Center identified specific leukemia gene mutations and the mechanisms by which they regulate DNA repair and respond to PARP inhibitors.

13 Aug 2021

Potential new treatment for mast cell cancers reduces tumor size and prevents organ infiltration

A potential new treatment for mast cell cancers reduces the number of mast cells by "mutating" the messenger RNA (mRNA) before it can deliver instructions for manufacturing the gene responsible for cell proliferation.

10 Aug 2021

Cardioprotective role of HIF1α in COVID-19 patients

The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first emerged in Wuhan, China, in late December 2019, has quickly become the most urgent issue facing scientists worldwide. It has been reported that the respiratory infection causes cardiac dysfunction in 25-55% patients, including hospitalized patients and non-critical patients.

10 Aug 2021

Combination therapy improves outcomes for relapsed chronic lymphocytic leukemia

Shuo Ma, MD, '00 PhD, associate professor of Medicine in the Division of Hematology and Oncology, was co-first author of the clinical trial published in Blood.

5 Aug 2021

Researchers develop the most comprehensive molecular map of lung squamous cell carcinoma

Lung cancer remains the leading cause of cancer-associated death in the United States and worldwide. Patients with a subtype called lung adenocarcinoma (LUAD) have benefited from the development of new targeted medicines, but the search for effective new therapies for another subtype called lung squamous cell carcinoma (LSCC) has largely come up short.

5 Aug 2021

UAB researchers identify potential therapeutic target for ovarian cancer

A gene called DOT1L appears to play a role in progression and severity of ovarian cancer, and inhibitors of the DOT1L enzyme may offer a new therapeutic approach for the disease, University of Alabama at Birmingham researchers say in a study published in the journal Oncogenesis.

5 Aug 2021

Discovery may enable the development of new therapies to kill aggressive cancer cells

Vanderbilt faculty and researchers are looking for the "Achilles' heel" of the cancer cells that survive initial chemotherapy.

3 Aug 2021

Study finds a significant link between statins and survival rates of triple-negative breast cancer patients

A study led by researchers from The University of Texas MD Anderson Cancer Center found a significant association between cholesterol-lowering drugs commonly known as statins and survival rates of triple-negative breast cancer patients. Since statins are low in cost, easy to access and produce minimal side effects, this could have an important impact on outcomes for this aggressive disease.

3 Aug 2021

Study reveals effective strategy to extend the benefit of immunotherapy for prostate cancer

It's a scientific riddle tangled up in a complex web. How do you turn an immune cold cancer into one that responds to immunotherapy?

2 Aug 2021

Researchers discover titanium oxide nanoparticle that recognizes SARS-CoV-2’s non-structural protein 1

A pioneering study reports on the interaction of a tailored titanium oxide nanoparticle (NP) with the full-length SARS-CoV-2 non-structural protein 1 (nsp1). This should be of value in developing new therapeutic tools against coronaviruses that act by targeting their proteins. It could also help map the structure of activated proteins.

2 Aug 2021

Polyuridine sequence of mouse coronavirus can be targeted to prevent host cell death

A new study reports the use of a modified deoxyribonucleic acid (DNA) oligonucleotide that has a 3’ polyadenine (polyA) tail to bind to the 5’-polyU tract in the mouse coronavirus (MHV-A59). Treatment of mouse cells infected with MHV-A59 with this molecule led to a marked reduction in cell deaths.

2 Aug 2021

Cell Death News and Research

Study may pave way for new treatment strategies to limit the progression of solid tumors

Adding berzosertib to standard treatment for metastatic urothelial cancer does not extend patient survival

Stiffening of heart’s blood vessels associated with lack of enzyme that fosters cell ‘chatter’

Study unravels widespread tumor suppression mechanism that halts cancer metastasis

Two studies on gastrointestinal stroma tumors describe advances that may lead to new treatments

Study suggests a novel therapeutic target to reverse lung fibrosis

New study identifies novel compound as promising pan-coronavirus drug candidate

Study identifies the cause and treatment for rare rheumatoid-like autoinflammatory condition

Simple roundworm may hold the key to understanding cell death processes

Specific leukemia gene mutations exert divergent effects on DNA repair and sensitivity to PARP Inhibitors

Potential new treatment for mast cell cancers reduces tumor size and prevents organ infiltration

Cardioprotective role of HIF1α in COVID-19 patients

Combination therapy improves outcomes for relapsed chronic lymphocytic leukemia

Researchers develop the most comprehensive molecular map of lung squamous cell carcinoma

UAB researchers identify potential therapeutic target for ovarian cancer

Discovery may enable the development of new therapies to kill aggressive cancer cells

Study finds a significant link between statins and survival rates of triple-negative breast cancer patients

Study reveals effective strategy to extend the benefit of immunotherapy for prostate cancer

Researchers discover titanium oxide nanoparticle that recognizes SARS-CoV-2’s non-structural protein 1

Polyuridine sequence of mouse coronavirus can be targeted to prevent host cell death

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