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Skin medication shows promise in treating alcohol use disorder

Researchers from Oregon Health & Science University and institutions across the country have identified a pill used to treat a common skin disease as an "incredibly promising" treatment for alcohol use disorder.

21 Feb 2023

Use of dapivirine vaginal ring during third trimester of pregnancy poses no safety concerns

A vaginal ring containing the antiretroviral drug dapivirine posed no safety concerns when used in the third trimester of pregnancy, according to results to date from the first study of the dapivirine ring during pregnancy and one of only a few studies of an HIV prevention product in pregnant cisgender women.

20 Feb 2023

Cannabidiol could help curb the urge for smoking cigarettes

Cannabidiol or CBD, a non-psychoactive component of cannabis, inhibits the metabolism of nicotine, new research has found, meaning it could help tobacco users curb the urge for that next cigarette.

16 Feb 2023

Nirmatrelvir-ritonavir therapy effective against Omicron BA.4/BA.5

Researchers examine non-hospitalized adult patients with COVID-19 treated with nirmatrelvir-ritonavir.

15 Feb 2023

What is the tolerability profile and rate of recurrent CDI after administrating microbiome therapeutic SER-109 post-antibiotic treatment?

Researchers investigated the tolerability and safety of a microbiome therapy called SER-109 to treat recurrent infections of Clostridioides difficile in adults.

15 Feb 2023

NIH initiates a clinical trial evaluating an investigational antiviral for treatment of COVID-19

The National Institutes of Health has initiated a multi-site clinical trial evaluating an investigational antiviral for the treatment of COVID-19.

15 Feb 2023

High doses of cannabidiol may increase the effects of THC in edible cannabis products

Contrary to some common claims, a study led by Johns Hopkins Medicine researchers found that relatively high doses of cannabidiol (CBD) may increase the adverse effects of delta-9-tetrahydrocannabinol (THC), the main active ingredient in cannabis that can cause a mood alteration or a "high" sensation.

13 Feb 2023

Neuroprotectant linked to reduced death and disability among stroke patients

The neuroprotectant ApTOLL, a medication that may shield the brain from tissue damage, was linked to reduced death and disability among people being treated for stroke when used with standard treatments to restore blood flow, according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2023.

13 Feb 2023

Declining PSA levels predict improved survival rates in men with non-metastatic castration-resistant prostate cancer

Declines in prostate-specific antigen (PSA) level after treatment with the next-generation androgen receptor inhibitor drug enzalutamide predict improved survival rates in men with non-metastatic castration-resistant prostate cancer (nmCRPC), reports The Journal of Urology, an Official Journal of the American Urological Association.

10 Feb 2023

Study: Single dose of common antibiotic given during labor reduces the risk of maternal death or sepsis

Sepsis - a severe infection in the body that can lead to tissue damage, organ failure, and death - is among the top causes of maternal deaths worldwide, according to the World Health Organization (WHO).

10 Feb 2023

Single dose of the antibiotic azithromycin decreases sepsis and death risk during childbirth

A single dose of the antibiotic azithromycin can help protect mothers from dangerous sepsis infections and death during vaginal childbirth, a sweeping new international study from a UVA Health scientist and his collaborators has found.

9 Feb 2023

Pegylated interferon lambda shows good efficacy against COVID-19

In a recent study published in The New England Journal of Medicine, researchers used the TOGETHER platform trial protocol to perform a phase III randomized controlled trial (RCT) to evaluate the effectiveness of pegylated interferon (IFN) lambda (λ) therapy in outpatients with coronavirus disease 2019 (COVID-19) in Canada and Brazil.

9 Feb 2023

Expert work group examines and redefines “clinical meaningfulness” in Alzheimer’s

As the Alzheimer's disease scientific community, patients, and families seek to understand the results of clinical trials of new Alzheimer's treatments, the Alzheimer's Association convened an expert work group to discuss an important and timely issue: the "clinical meaningfulness" of results from these studies.

7 Feb 2023

Men with low sexual desire might benefit from kisspeptin

A new study in the journal JAMA Network Open aimed to analyze the mechanistic and clinical effects of the administration of kisspeptin in men with HSDD.

7 Feb 2023

New Cochrane review: Taking vitamin D supplements does not reduce the risk of asthma attacks

Taking vitamin D supplements does not reduce the risk of asthma attacks in children or adults, according to an updated Cochrane review.

6 Feb 2023

Pembrolizumab in combination with chemotherapy improves progression free survival for women with advanced or recurrent endometrial cancer

NRG Oncology Phase III clinical trial, NRG-GY018, evaluating pembrolizumab in combination with standard of care chemotherapy (carboplatin and paclitaxel) met its primary endpoint of progression free survival (PFS) for the treatment of patients with stage III-IV or recurrent endometrial carcinoma, regardless of mismatch repair status.

3 Feb 2023

Molnupiravir-related mutational signatures among COVID-19 patients

Researchers explore a mutational signature related to molnupiravir in SARS-CoV-2 sequencing datasets.

3 Feb 2023

BCG vaccine does not protect elderly with co-morbidities against COVID-19

The tuberculosis vaccine (or BCG vaccine) does not protect elderly with co-morbidities against disease symptoms caused by a coronavirus infection.

2 Feb 2023

Trial shows the benefit of using a celery seed-derived medication after clot treatment in stroke patients

People who had an ischemic (clot-caused) stroke and were treated with a clot-busting medication and/or mechanical clot removal and also received butylphthalide, a medication initially compounded from celery seed, experienced milder neurological symptoms with better functioning at three months after the stroke, compared to stroke patients who had their clots treated but received a placebo medication, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2023.

2 Feb 2023

A more nuanced approach is needed when prescribing antidepressants for pain, researchers say

Some antidepressant drugs are effective for some pain conditions, but most are either ineffective or the evidence is inconclusive, despite being used for a range of pain conditions, finds an overview of the latest evidence published by The BMJ today.

1 Feb 2023

Placebo News and Research

Skin medication shows promise in treating alcohol use disorder

Use of dapivirine vaginal ring during third trimester of pregnancy poses no safety concerns

Cannabidiol could help curb the urge for smoking cigarettes

Nirmatrelvir-ritonavir therapy effective against Omicron BA.4/BA.5

What is the tolerability profile and rate of recurrent CDI after administrating microbiome therapeutic SER-109 post-antibiotic treatment?

NIH initiates a clinical trial evaluating an investigational antiviral for treatment of COVID-19

High doses of cannabidiol may increase the effects of THC in edible cannabis products

Neuroprotectant linked to reduced death and disability among stroke patients

Declining PSA levels predict improved survival rates in men with non-metastatic castration-resistant prostate cancer

Study: Single dose of common antibiotic given during labor reduces the risk of maternal death or sepsis

Single dose of the antibiotic azithromycin decreases sepsis and death risk during childbirth

Pegylated interferon lambda shows good efficacy against COVID-19

Expert work group examines and redefines “clinical meaningfulness” in Alzheimer’s

Men with low sexual desire might benefit from kisspeptin

New Cochrane review: Taking vitamin D supplements does not reduce the risk of asthma attacks

Pembrolizumab in combination with chemotherapy improves progression free survival for women with advanced or recurrent endometrial cancer

Molnupiravir-related mutational signatures among COVID-19 patients

BCG vaccine does not protect elderly with co-morbidities against COVID-19

Trial shows the benefit of using a celery seed-derived medication after clot treatment in stroke patients

A more nuanced approach is needed when prescribing antidepressants for pain, researchers say

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