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GPR141 drives breast tumorigenesis by inducing tumor cell properties via the p-mTOR1/p53 axis

A new research paper was published in Oncotarget's Volume 14 on May 19, 2023, entitled, "G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis."

23 May 2023

Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Research unveils the significance of uridine as a metabolic fuel in pancreatic ductal adenocarcinoma (PDA) cells under glucose-deprived conditions. Uridine utilization, mediated by uridine phosphorylase 1 (UPP1), supports redox balance, survival, and proliferation in PDA, highlighting its potential as a novel therapeutic target in the treatment of this resistant cancer.

23 May 2023

Surviving without glucose: uridine-derived ribose as an alternative energy source

Researchers attempted to identify new genes and molecular pathways that might supply energy when the availability of glucose or other nutrients is limited.

22 May 2023

Hydrogel combines nanozymes and probiotics for effective Candida vaginitis treatment

Research introduces FeLab, a responsive hydrogel that combines nanozymes and probiotics for the treatment of Candida vaginitis. FeLab demonstrates effective anti-Candida activity, promotes vaginal mucosa repair, and restores healthy vaginal microbiota, offering a promising therapeutic approach for this condition.

21 May 2023

Indirect inhibitors of cellular respiration for treatment of glioblastoma

A new research perspective was published in Oncotarget's Volume 14 on May 4, 2023, entitled, "Targeting cellular respiration as a therapeutic strategy in glioblastoma."

19 May 2023

Researchers discover sex-specific genes, molecular pathways that contribute to Alzheimer's disease progression

Alzheimer's Disease (AD) is a complex neurodegenerative illness with genetic and environmental origins.

19 May 2023

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Researchers derived peptides from the SARS-CoV-2 spike protein to assess COVID-19-associated inflammatory changes using zebrafish models.

19 May 2023

Both vaccine strain and adjuvant selection are critical elements for improving the breadth of protective immunity against enterovirus D68

Researchers demonstrated the production of cross-clade neutralizing antibodies in response to EV-D68.

19 May 2023

Turn down the heat: Spicy foods linked to memory decline in inactive seniors

Research investigates the association between spicy food consumption and Alzheimer's disease (AD) or cognitive decline in older adults. The study found that a high level of spiciness in food is associated with decreased memory or global cognition, and this relationship is worsened by a physically inactive lifestyle.

18 May 2023

Food preservative nisin: A gut game changer that safely alters microbiome composition

Nisin, a powerful bacteriocin, influences the gut microbiota and its functionality by modulating the abundance of specific bacterial groups and altering short-chain fatty acid synthesis.

18 May 2023

How estrogens and progesterone present in human milk impact infants' health

Review examines the presence of estrogens and progesterone in human milk and their potential impact on infant growth and health. It explores factors influencing hormone levels and provides insights for effective intervention strategies.

18 May 2023

Researchers identify a major stem cell variant in lungs of patients with idiopathic pulmonary fibrosis

A pair of internationally renowned stem cell cloning experts at the University of Houston is reporting their findings of variant cells in the lungs of patients with Idiopathic Pulmonary Fibrosis (IPF) which likely represent key targets in any future therapy for the condition.

17 May 2023

Novel antibodies target human receptors to neutralize SARS-CoV-2 variants and future sarbecoviruses

Researchers generated six human monoclonal antibodies that prevented infection.

17 May 2023

Machine learning reveals sex-specific Alzheimer's risk genes

Research explores sex-specific gene associations in Alzheimer's disease using a machine-learning approach. It reveals immune response pathways in both sexes and stress-response pathways in males, highlighting potential biomarkers and therapeutic targets for personalized treatments.

16 May 2023

Molecular mechanism behind a DNA repair pathway revealed

A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA.

16 May 2023

HER2-TPMC proves to be a reasonable alternative for HER2-positive cancer chemotherapeutics

Announcing a new article publication for BIO Integration journal. Antibody-drug conjugates (ADCs) have the following advantages: target specificity; wide therapeutic index; and prolonged circulation half-life.

15 May 2023

Study shows two distinct types of cerebellar neurons differentially regulate motor and social behaviors

The cerebellum, a major part of the hindbrain in all vertebrates, is important for motor coordination, language acquisition, and regulating social and emotional behaviors.

15 May 2023

Phase 1 clinical trial of CAR-NKT cell therapy shows promising results in neuroblastoma patients

Researchers at Baylor College of Medicine/Texas Children's Cancer Center and collaborating institutions report interim results from a first-in-human phase 1 clinical trial evaluating the safety, antitumor activity and immunological characteristics of a genetically engineered natural killer T (NKT) cell immunotherapy for neuroblastoma, a childhood tumor that most commonly arises in the adrenal gland.

15 May 2023

Humanized mouse model for rare genetic disease developed for the first time

Mice with a defected human gene responsible for a rare genetic disease, called congenital adrenal hyperplasia, have been developed for the first time.

15 May 2023

Nanoparticles take aim at COVID-19 with lysosome-targeted delivery

Researchers discuss the use of endo-lysosome-targeted nanoparticles for delivering antiviral therapy to treat coronavirus infections.

15 May 2023

in vivo News and Research

GPR141 drives breast tumorigenesis by inducing tumor cell properties via the p-mTOR1/p53 axis

Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Surviving without glucose: uridine-derived ribose as an alternative energy source

Hydrogel combines nanozymes and probiotics for effective Candida vaginitis treatment

Indirect inhibitors of cellular respiration for treatment of glioblastoma

Researchers discover sex-specific genes, molecular pathways that contribute to Alzheimer's disease progression

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Both vaccine strain and adjuvant selection are critical elements for improving the breadth of protective immunity against enterovirus D68

Turn down the heat: Spicy foods linked to memory decline in inactive seniors

Food preservative nisin: A gut game changer that safely alters microbiome composition

How estrogens and progesterone present in human milk impact infants' health

Researchers identify a major stem cell variant in lungs of patients with idiopathic pulmonary fibrosis

Novel antibodies target human receptors to neutralize SARS-CoV-2 variants and future sarbecoviruses

Machine learning reveals sex-specific Alzheimer's risk genes

Molecular mechanism behind a DNA repair pathway revealed

HER2-TPMC proves to be a reasonable alternative for HER2-positive cancer chemotherapeutics

Study shows two distinct types of cerebellar neurons differentially regulate motor and social behaviors

Phase 1 clinical trial of CAR-NKT cell therapy shows promising results in neuroblastoma patients

Humanized mouse model for rare genetic disease developed for the first time

Nanoparticles take aim at COVID-19 with lysosome-targeted delivery

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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