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New approach for extensive screening of monoclonal antibody clones against multiple myeloma cells

Multiple myeloma (MM) is a largely incurable cancer of plasma cells with an extremely poor prognosis. However, investigators from Japan have recently found that a common component of amino acid transporters, CD98 heavy chain, represents an effective monoclonal antibody target in treating MM.

22 Feb 2022

Study explores the decline in viral load and immune response in COVID-19 patients

Researchers described the changes in viral ribonucleic acid the decline in viral load, and the immune response of SARS-CoV-2-infected patients, in a new preprint study.

22 Feb 2022

Lung microbiome alterations and secondary-infections in lethal COVID-19

Researchers examined how an interplay of host and microbial factors weakened immunity leading to secondary infections in COVID-19-infected individuals.

22 Feb 2022

Study suggests anti-SARS-CoV-2 antibodies may persist lifelong post-infection

Researchers attempted to delineate the duration and stability of anti-SARS-CoV-2 antibodies in patients who had recovered from the COVID-19 infection.

22 Feb 2022

An abundance of SARS-CoV-2-like viruses in hunted wild animals traded in China

New research published in the journal Cell assesses the viromes of 18 different species of game animals across China to predict potential pathogens similar to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could infect human populations.

22 Feb 2022

Mouse-adapted virus model to study persistent COVID induced lung disease

Researchers develop a mouse model to identify early biomarkers and test countermeasures needed to detect and prevent PASC.

21 Feb 2022

Mathematical model suggests a clue as to when COVID-19 pandemic will turn into an endemic

A mathematical model demonstrated that high transmission rates among highly vaccinated populations of COVID-19 ultimately reduce the numbers of severe cases. This model suggests a clue as to when this pandemic will turn into an endemic.

21 Feb 2022

Researchers discover how pre-transplant chemotherapy facilitates the replacement of microglial cells

More than 50,000 bone marrow-derived stem cell transplants are performed worldwide each year to treat a wide range of conditions, including brain diseases.

21 Feb 2022

Broad-spectrum antiviral activity of picolinic acid against SARS-CoV-2 and Influenza A virus

Researchers investigate the potential of picolinic acid (PA) as an anti-SARS-CoV-2 treatment option.

21 Feb 2022

Novel ACE2-blocking antibody protects against all SARS-CoV-2 VOCs

Researchers identify 87G7, a SARS-CoV-2 neutralizing human monoclonal antibody with remarkable broad-spectrum neutralization and protection efficacy.

21 Feb 2022

Scientists use entire human GI tracts to shed light on cellular functions

If you get nervous, you might feel it in your gut. If you eat chili, your gut might revolt, but your friend can eat anything and feel great. You can pop ibuprofen like candy with no ill effects, but your friend's belly might bleed and she might get no pain relief.

21 Feb 2022

Partially matched blood cells could help cure people with both cancer and HIV

Following the news that a third person has been cured of HIV, a Northwestern Medicine expert says partially matched blood cells could be used to cure many people living with both cancer and HIV.

21 Feb 2022

The logic that controls gene regulation in human cells discovered

A research group at the University of Helsinki has discovered the logic that controls gene regulation in human cells. In the future, this new knowledge can be applied to, for example, investigating cancers and other genetic diseases.

21 Feb 2022

Researchers unravel essential final steps in the production of mRNA

Proteins need to interact in a complex manner for a so-called "messenger RNA" (mRNA) to be created in human cells from a precursor molecule. mRNA provides a blueprint for proteins; the first vaccines against the coronavirus are also based on mRNAs.

21 Feb 2022

TTUHSC expert wins NIH renewal grant to continue research on neurological disorders

According to the Global Burden of Disease study, neurological disorders are the leading cause of disability and the second leading cause of death after heart disease.

21 Feb 2022

Study offers new understanding of how the immune system reacts to COVID-19

Little has been known to date about how the immune system's natural killer (NK) cells detect which cells have been infected with SARS-CoV-2.

21 Feb 2022

Molecular characteristics of SARS-CoV-2 variants enabling antibody escape

A new review paper published in PLoS Pathogens discusses the new variants and the structural mechanism underlying antibody-mediated neutralization as well as mutational antibody escape.

21 Feb 2022

Mathematical model of host immune response to SARS-CoV-2 demonstrates that age-related risk factors increased viral load

Researchers evaluated the host immune responses to SARS-CoV-2 and its prolonged symptoms.

21 Feb 2022

Surfactant-containing oral mouthwashes target the lipid envelope of SARS-CoV-2

Researchers demonstrated the composition and importance of SARS-CoV-2 lipid envelope and assessed the antiviral potential of oral mouthwashes targeting these lipid envelopes.

21 Feb 2022

Biochemical changes in lung physiology not responsible for severe clinical outcomes in the older population

Researchers investigated whether age-dependent changes in lung physiology make the elderly disproportionately susceptible to SARS-CoV-2 infection.

21 Feb 2022

B Cell News and Research

New approach for extensive screening of monoclonal antibody clones against multiple myeloma cells

Study explores the decline in viral load and immune response in COVID-19 patients

Lung microbiome alterations and secondary-infections in lethal COVID-19

Study suggests anti-SARS-CoV-2 antibodies may persist lifelong post-infection

An abundance of SARS-CoV-2-like viruses in hunted wild animals traded in China

Mouse-adapted virus model to study persistent COVID induced lung disease

Mathematical model suggests a clue as to when COVID-19 pandemic will turn into an endemic

Researchers discover how pre-transplant chemotherapy facilitates the replacement of microglial cells

Broad-spectrum antiviral activity of picolinic acid against SARS-CoV-2 and Influenza A virus

Novel ACE2-blocking antibody protects against all SARS-CoV-2 VOCs

Scientists use entire human GI tracts to shed light on cellular functions

Partially matched blood cells could help cure people with both cancer and HIV

The logic that controls gene regulation in human cells discovered

Researchers unravel essential final steps in the production of mRNA

TTUHSC expert wins NIH renewal grant to continue research on neurological disorders

Study offers new understanding of how the immune system reacts to COVID-19

Molecular characteristics of SARS-CoV-2 variants enabling antibody escape

Mathematical model of host immune response to SARS-CoV-2 demonstrates that age-related risk factors increased viral load

Surfactant-containing oral mouthwashes target the lipid envelope of SARS-CoV-2

Biochemical changes in lung physiology not responsible for severe clinical outcomes in the older population

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