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Scientists are exploring to find the 'Achilles heel' of coronavirus

Coronavirus, or more exactly SARS-CoV-2, has the world in its grip. How does the virus manage to bind to cells in the human body? How does it gain entry to the cell? How does it hijack the cell's machinery to make it help to replicate the viral genome?

5 May 2020

Researchers discover new gene involved in regulating the body's cholesterol

Precision medicine has the potential to tailor treatments to a patient's unique genetic sequence. But achieving this precision -- or developing new drugs -- requires knowing which genes are involved in disease.

4 May 2020

Activation of estrogen receptor can impede growth of pancreatic cancer cells

Activating the G protein-coupled estrogen receptor - a receptor found on the surface of many normal and cancer tissues - has been shown to stop pancreatic cancer from growing, but may also make tumors more visible to the immune system and thus more susceptible to modern immunotherapy.

4 May 2020

ASU team identifies new, unique SARS-CoV-2 mutation

As the coronavirus pandemic has swept across the U.S., in addition to tracking the number of COVID daily cases, there is a worldwide scientific community engaged in tracking the SARS-CoV-2 virus itself.

4 May 2020

MU researcher finds four antiviral drugs effective in inhibiting novel coronavirus

Now, a researcher at the University of Missouri has found that four antiviral drugs, including remdesivir, a drug originally developed to treat Ebola, are effective in inhibiting the replication of the coronavirus causing COVID-19.

4 May 2020

AHA calls for specialized care for pregnant women with cardiovascular conditions

Women with cardiovascular conditions should be cared for during pregnancy by a cardio-obstetrics team or health care providers experienced in high-risk pregnancies to provide specialized maternity care for the mother and fetus, according to a new American Heart Association scientific statement, Cardiovascular Considerations in Caring for Pregnant Patients, published today in the Association's flagship journal Circulation.

4 May 2020

Researchers discover hidden symmetry in chemical kinetic equations

Rice University researchers have discovered a hidden symmetry in the chemical kinetic equations scientists have long used to model and study many of the chemical processes essential for life.

4 May 2020

RA patients enrolled in Medicare plan face significant cost exposure on specialty drugs

After a sharp drop in out-of-pocket costs between 2010 and 2011, Medicare patients who use specialty biologic medications for rheumatoid arthritis have seen higher out-of-pocket spending for those same drugs because of gradual price increases, a new study in the Journal of the American Medical Association Open finds.

4 May 2020

Blood sugar control is key for people with type 2 diabetes and COVID-19

A study reported in the journal Cell Metabolism on April 30 adds to the evidence that people with type 2 diabetes (T2D) are at greater risk of a poor outcome should they become infected with the virus that causes COVID-19.

4 May 2020

Scripps professor receives Research Program Award for advancing RNA-targeting medicines

In recognition of his high-impact work advancing the field of RNA-targeting medicines, the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, has awarded Scripps Research Chemistry Professor Matthew Disney, PhD, a prestigious Research Program Award, to aid Disney's development of treatments for incurable diseases such as Alzheimer's, Parkinson's, ALS and frontotemporal dementia.

4 May 2020

Hydroxychloroquine combined with azithromycin and abnormal heart rhythms in COVID-19 patients

A new study shows that the initially lauded combination of drugs against COVID-19 - Hydroxychloroquine and Chloroquine combined with azithromycin, could lead to abnormal and life-threatening heart rhythms. In patients hospitalized with the novel coronavirus infection or SARS CoV-2, this combination can lead to prolonged QT interval as can be detected on ECG.

3 May 2020

Study reveals antiviral properties of glycosaminoglycans against SARS-CoV-2

Glycosaminoglycans can inhibit cell invasion by acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses, which supports the utilization of such therapeutics in the fight against coronavirus disease (COVID-19) – reports a new study available on the preprint server bioRxiv.

3 May 2020

Low molecular weight heparins inhibit SARS-CoV-2 cell invasion

A recent paper available on the preprint server bioRxiv* reports preliminary data on the ability of low molecular weight heparins to interact with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), elicit structural changes in its key proteins and subsequently halt cell invasion.

3 May 2020

Inventor of hepatitis C cure wins prestigious award from University of Edinburgh

A medicinal chemist who found a cure for the viral disease hepatitis C has received a prestigious award from the University of Edinburgh.

3 May 2020

Real-time monitoring of biochemical processes on DNA using infrared spectroscopy

DNA damage in general and DNA strand breaks in particular occur every day in all cells of the human body.

3 May 2020

Study reports cryo-EM structure of Remdesivir-bound RNA replicase complex from SARS-CoV-2

A team of Chinese scientists have reported the high-resolution cryo-EM structure of Remdesivir-bound RNA replicase complex from SARS-CoV-2, the infective virus of COVID-19.

3 May 2020

High blood pressure drugs found to be safe for COVID-19 patients

Despite concerns expressed by some experts, common high blood pressure drugs did not increase the risk of contracting COVID-19 - or of developing severe disease - in a study of 12,594 patients.

3 May 2020

Research reveals mechanism underlying Parkinson's dyskinesia

Many people with Parkinson's disease eventually develop debilitating movements called dyskinesia, a side effect of their much-needed dopamine replacement medication.

3 May 2020

AHA awards grants to 12 teams for fast-tracked heart and brain health research related to COVID-19

Less than a month after issuing a rapid response call for scientific research proposals for fast-tracked studies of the effects of COVID-19 on the body's cardiovascular and cerebrovascular systems, the American Heart Association has awarded $1.2 million in grants to teams at 12 institutions across the U.S. to begin this unprecedented work.

2 May 2020

UBC discovery could pave way for developing new anti-malarial drugs

For the first time, UBC researchers have shown a key difference in the three-dimensional structures of a key metabolic enzyme in the parasite that causes malaria compared to its human counterpart.

2 May 2020

Drugs News and Research

Scientists are exploring to find the 'Achilles heel' of coronavirus

Researchers discover new gene involved in regulating the body's cholesterol

Activation of estrogen receptor can impede growth of pancreatic cancer cells

ASU team identifies new, unique SARS-CoV-2 mutation

MU researcher finds four antiviral drugs effective in inhibiting novel coronavirus

AHA calls for specialized care for pregnant women with cardiovascular conditions

Researchers discover hidden symmetry in chemical kinetic equations

RA patients enrolled in Medicare plan face significant cost exposure on specialty drugs

Blood sugar control is key for people with type 2 diabetes and COVID-19

Scripps professor receives Research Program Award for advancing RNA-targeting medicines

Hydroxychloroquine combined with azithromycin and abnormal heart rhythms in COVID-19 patients

Study reveals antiviral properties of glycosaminoglycans against SARS-CoV-2

Low molecular weight heparins inhibit SARS-CoV-2 cell invasion

Inventor of hepatitis C cure wins prestigious award from University of Edinburgh

Real-time monitoring of biochemical processes on DNA using infrared spectroscopy

Study reports cryo-EM structure of Remdesivir-bound RNA replicase complex from SARS-CoV-2

High blood pressure drugs found to be safe for COVID-19 patients

Research reveals mechanism underlying Parkinson's dyskinesia

AHA awards grants to 12 teams for fast-tracked heart and brain health research related to COVID-19

UBC discovery could pave way for developing new anti-malarial drugs

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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