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New nanoparticles disable drug resistance to achieve complete tumor elimination

Cancer cells frequently develop the ability to expel anticancer drugs before they can work -- a phenomenon called multidrug resistance (MDR) -- which is one of the leading reasons why chemotherapy fails in patients.

8 May 2026

Metformin targets the gut instead of the liver to lower glucose

For decades, physicians and scientists thought metformin, the leading Type 2 diabetes medication taken by millions worldwide, mainly targets the liver to suppress glucose production.

8 May 2026

The power of organoids in speeding up lifesaving drug development

Organoids are miniature tissue or organ models formed by stem cells (including pluripotent stem cells, tissue-specific adult stem cells, etc.) or progenitor cells in an in vitro three-dimensional culture system, which possess structural features and partial functions analogous to their corresponding in vivo organs. In 2009, the Hans Clevers laboratory developed the first intestinal organoid, marking the inception of organoid-based disease modeling.

8 May 2026

New genetic link found for sudden cardiac death in young people

Short QT syndrome is a genetic disease that leads to sudden cardiac death at a young age. Mutations in the SLC4A3 gene, which regulates bicarbonate-chloride exchange, were recently described as a potential cause. An international research team, including a group from Ruhr University Bochum, Germany, investigated this possibility.

8 May 2026

Prisoners in England face dramatically higher rates of avoidable healthcare harms

Prisoners in England are 41 to 67 times more likely to experience avoidable harms as a result of poor healthcare than the general public, suggest the findings of a case note review of medical records, published online in the journal BMJ Quality & Safety.

8 May 2026

Neurodegeneration in Down syndrome may begin shortly after birth

Signs of neurodegeneration in individuals with Down syndrome may start as early as birth, a critical stage of brain development, a new study shows.

8 May 2026

Study links mitochondrial health to effectiveness of anti-aging pathways

Mississippi State University biologist Jean-Francois Gout's contributions to a study highlighting key advances in the complexity of aging now are published in Science Advances, a leading peer-reviewed journal of the American Association for the Advancement of Science.

7 May 2026

Diverse leukemia stem cells may drive AML relapse after therapy

Scientists from the German Cancer Research Center (DKFZ) and the HI-STEM* Stem Cell Institute have deciphered a key mechanism that contributes to treatment failure in acute myeloid leukemia (AML).

7 May 2026

Blocking TGF-beta may enhance osteoporosis bone regeneration therapies

A recent mouse model based study suggests that blocking TGF-β may improve osteoporosis treatment by helping quiescent osteoblasts in inactive bone surfaces return to an active state.

7 May 2026

Chromosome abnormalities may help cancer cells resist treatment and spread

A new study led by NYU Langone Health researchers found that cancer cells are better able to resist treatments when they have an abnormal number of chromosomes, which are DNA strands wound up in bundles that control which genetic instructions are followed in each cell type.

7 May 2026

Study reveals why women face higher autoimmune disease risks

Ahead of World Lupus Day on May 10, new research from the Garvan Institute of Medical Research and UNSW Sydney helps explain why women are significantly more likely to be diagnosed with an autoimmune disease – a condition where the immune system misfires and mistakenly attacks the body's own healthy tissues.

7 May 2026

Study reveals how magnetic stimulation repairs depression-related brain circuits

Transcranial magnetic stimulation (TMS) is a non-invasive, FDA-approved therapy that uses brief magnetic pulses to treat depression, particularly in patients who do not respond to medication.

7 May 2026

JAYseq test delivers rapid genomic profiling for multiple myeloma patients

The Translational Genomics Research Institute (TGen), part of City of Hope, today announced the launch of JAYseqTM, a clinical whole-genome sequencing (WGS) test specifically for multiple myeloma.

7 May 2026

Scientists identify powerful human antibodies capable of neutralizing measles virus

Scientists at La Jolla Institute for Immunology (LJI) are the first in the world to characterize human antibodies capable of neutralizing measles virus.

7 May 2026

Garlic-derived compound may help improve muscle strength during aging

Can a compound derived from a common kitchen ingredient help support muscle health during aging? A new study suggests it can.

7 May 2026

Many metastatic lung cancer patients still receive no treatment options

About half of people diagnosed with metastatic non-small-cell lung cancer never receive treatment, despite advances in options over recent decades that have created meaningful improvements in lifespan and quality of life for many patients.

7 May 2026

Cell swelling in macrophages may trigger stronger inflammatory immune responses

As part of the body's first line of defense against foreign invaders, macrophages play an integral role in the innate immune system.

7 May 2026

A new combined therapy to boost the immune system against cancer

Cancer immunotherapy is built on a simple but powerful idea: the immune system can recognize and destroy cancer cells if it is properly activated. In many patients, however, this response is too weak or too slow to be effective.

7 May 2026

New ‘heart-on-a-chip’ to halt cardiac damage caused by Duchenne

Duchenne Parent Project Spain (DPPE) has launched the BEAT Project, a research initiative focused on one of the key challenges associated with Duchenne and Becker muscular dystrophies: progressive heart damage. Cardiomyopathy is the leading cause of death in patients with DMD.

7 May 2026

Kyoto University identifies a key regulator of insulin production

A hallmark of Type 2 diabetes is the progressive loss of beta cell mass: cells in the pancreas that produce and release insulin. The endoplasmic reticulum stress response, a cellular pathway that maintains protein homeostasis, plays a critical role in beta cell function and survival, and the protein ATF6α is one of the key regulators of this stress response.

7 May 2026