Cell Death News and Research

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Could novel biosensors facilitate SARS-CoV-2 antiviral drug research?

An intriguing new study presents a novel approach to biosensor-based evaluation of promising drugs that could inhibit the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via its 3C-like protease (3CLpro), a viral protease.

2 Aug 2021

Study provides new understanding on function of mitofusin 2 in cellular energy metabolism

Mitofusin 2 is a key protein in the regulation of the physiology of mitochondria ─cellular organelles that produce energy─ involved in several neurodegenerative and cardiovascular diseases, as well as in cancer.

30 Jul 2021

Study examines the role of programmed cell death ligands in skin immune responses

T cells are a crucial part of the human adaptive immune system. In response to a foreign invader in the body, various subsets of T cells are responsible for several functions that include killing infected cells and secreting signaling molecules called cytokines that tell other immune cells where to go and what to do.

29 Jul 2021

Analysis of DNA tags could advance the understanding and treatment of many cancers

Cell-free DNA (cfDNA) shed into the blood was discovered in the late 1940s but with rapid advances in genomics and computational analytics in just the past few years, researchers at Georgetown Lombardi Comprehensive Cancer Center now believe that studying tags, or modifications to this type of DNA, may lead to a better understanding of how to assess, and possibly modulate, treatment approaches for cancer and other diseases.

27 Jul 2021

Mount Sinai researchers use cerebral organoids to study frontotemporal dementia

Frontotemporal dementias are a group of fatal and debilitating brain disorders for which there are no cures.

26 Jul 2021

Gene therapy protects optic nerve cells and preserves vision in glaucoma mouse models

A form of gene therapy protects optic nerve cells and preserves vision in mouse models of glaucoma, according to research supported by NIH's National Eye Institute.

23 Jul 2021

MUSC Hollings Cancer Center part of promising phase 2 lymphoma clinical trial

MUSC Hollings Cancer Center was one of 28 clinical sites around the world that participated in the LOTIS-2 trial to test the efficacy of Loncastuximab tesirine, a promising new treatment for aggressive B-cell lymphoma.

23 Jul 2021

Injecting mice with pulmonary endothelial cells can reverse symptoms of emphysema

Researchers at Weill Cornell Medicine and NewYork-Presbyterian in New York have discovered that injecting mice with pulmonary endothelial cells-the cells that line the walls of blood vessels in the lung-can reverse the symptoms of emphysema.

21 Jul 2021

Scientists identify key role of p38-MK2 pathway in determining cell fate in response to stress

Living organisms are often exposed to stress stimuli generated either by external or internal factors, and they need to respond accordingly.

20 Jul 2021

Exhausted T cells linked to increased risk of COVID-19 mortality

New research led by Nadia R. Roan of Gladstone Institutes and the University of California, San Francisco, finds a correlation between high numbers of inflammatory CXCR4+ T cells and regulatory T cells specific to SARS-CoV-2 and dying from infection. In contrast, people who recovered from severe COVID-19 illness were more likely to have many SARS-CoV-2-specific T cells that perform homeostatic proliferation.

20 Jul 2021

Deadly spider venom could help prevent damage from heart attacks

A potentially life-saving treatment for heart attack victims has been discovered from a very unlikely source - the venom of one of the world's deadliest spiders.

19 Jul 2021

New algorithm can be a more effective way to analyze models of biological systems

From biochemical reactions that produce cancers, to the latest memes virally spreading across social media, simple actions can generate complex behaviors.

16 Jul 2021

Autophagy disruption may be at the root of early cognitive changes in Huntington’s disease

Huntington's Disease (HD) is a progressive neurodegenerative condition characterized by motor, cognitive, and psychiatric symptoms, and motor symptoms are often preceded by cognitive changes.

15 Jul 2021

Quantum physics helps trigger cancer cell death

Cancer cell death is triggered within three days when X-rays are shone onto tumor tissue containing iodine-carrying nanoparticles.

14 Jul 2021

Is niclosamide a potential SARS-CoV-2 antiviral inhibitor?

Niclosamide is an antihelminthic drug, historically used to treat tapeworm infestations, though has been investigated and repurposed for use against SARS-CoV-2. In a new study recently uploaded to the preprint server bioRxiv* by Garrett et al. (July 12, 2021), the drug demonstrates the ability to reorganize the lipid profile of SARS-CoV-2 infected Vero E6 cells, thereby limiting virus replication.

14 Jul 2021

Study uncovers how specific bacteria contribute to common, recurrent gynecological condition

Bacterial vaginosis is the most common and recurrent gynecological condition affecting nearly 30% of women between the ages of 15 and 44, according to the U.S. Centers for Disease Control and Prevention.

14 Jul 2021

Study opens up new opportunities for controlling tuberculosis

Boosting the body's own disease-fighting immune pathway could provide answers in the desperate search for new treatments for tuberculosis.

12 Jul 2021

Malfunction in the cell’s powerhouse causes sporadic Parkinson disease

The major cause of Parkinson’s Disease is a dysregulation of immune genes central for fighting against viruses, a new study reveals.

9 Jul 2021

Scientists unravel mechanisms involved in epithelial integrity

To enable tissue renewal, human tissues constantly eliminate millions of cells, without jeopardizing tissue integrity, form and connectivity.

9 Jul 2021

Enzyme inhibitor boosts immune system to fight MRSA and other dangerous skin infections

In what turned out to be one of the most important accidents of all time, Scottish bacteriologist Alexander Fleming returned to his laboratory after a vacation in 1928 to find a clear zone surrounding a piece of mold that had infiltrated a petri dish full of Staphylococcus aureus (S. aureus), a common skin bacterium he was growing.

8 Jul 2021

Cell Death News and Research

Could novel biosensors facilitate SARS-CoV-2 antiviral drug research?

Study provides new understanding on function of mitofusin 2 in cellular energy metabolism

Study examines the role of programmed cell death ligands in skin immune responses

Analysis of DNA tags could advance the understanding and treatment of many cancers

Mount Sinai researchers use cerebral organoids to study frontotemporal dementia

Gene therapy protects optic nerve cells and preserves vision in glaucoma mouse models

MUSC Hollings Cancer Center part of promising phase 2 lymphoma clinical trial

Injecting mice with pulmonary endothelial cells can reverse symptoms of emphysema

Scientists identify key role of p38-MK2 pathway in determining cell fate in response to stress

Exhausted T cells linked to increased risk of COVID-19 mortality

Deadly spider venom could help prevent damage from heart attacks

New algorithm can be a more effective way to analyze models of biological systems

Autophagy disruption may be at the root of early cognitive changes in Huntington’s disease

Quantum physics helps trigger cancer cell death

Is niclosamide a potential SARS-CoV-2 antiviral inhibitor?

Study uncovers how specific bacteria contribute to common, recurrent gynecological condition

Study opens up new opportunities for controlling tuberculosis

Malfunction in the cell’s powerhouse causes sporadic Parkinson disease

Scientists unravel mechanisms involved in epithelial integrity

Enzyme inhibitor boosts immune system to fight MRSA and other dangerous skin infections

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

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Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics