Leukemia News and Research

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Leukemia (Leukaemia) is a cancer of the blood cells. It is the most common type of blood cancer and affects 10 times as many adults as children. Most people diagnosed with leukemia are over 50 years old. No one knows why some people develop leukemia and others do not. However, scientists have identified some risk factors for the disease. Most people who have known risk factors do not get leukemia, while many who do get the disease have none of these risk factors. During the early stages of leukemia, there may be no symptoms. Many of the symptoms of leukemia don't become apparent until a large number of normal blood cells are crowded out by leukemia cells.

Study provides most detailed classification of acute myeloid leukemia, myelodysplastic syndrome

Results from a study conducted by St. Jude Children's Research Hospital and the Munich Leukemia Laboratory were presented today as a late-breaking abstract at the American Society of Hematology annual meeting. The study integrates genomic and transcriptomic sequencing to provide the most detailed classification of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) to date.

10 Dec 2019

Researchers aim to exploit DNA mutations in the treatment of blood and bone marrow cancers

In a clinical trial led by Yale Cancer Center and Smilow Cancer Hospital, researchers aim to exploit DNA mutations in the treatment of two blood and bone marrow cancers, a different tacit than the more traditional approach of blunting or switching off genetic mutations linked to cancer.

10 Dec 2019

Transplant patient finds out his DNA has been replaced by that of his donor

A bone marrow transplant recipient later found out that the DNA in his blood and semen had been replaced by that of his donor.

10 Dec 2019

Immunotherapy more effective than chemotherapy for children, young adults with relapsed B-ALL

New findings from a clinical trial show that treatment with the immunotherapy drug blinatumomab is superior to standard chemotherapy for children and young adults with high- or intermediate-risk B-cell acute lymphoblastic leukemia that has relapsed.

10 Dec 2019

Risk of specific genetic translocation is higher in patients of African ancestry, shows study

Multiple myeloma is a plasma cell cancer that is more common in patients of African American descent than of European American descent.

10 Dec 2019

Scientists highlight the benefits of Droplet Digital PCR technology at the 2019 ASH meeting

Scientists will present more than 40 abstracts highlighting research driven in part by Bio-Rad Laboratories' Droplet Digital PCR (ddPCR) technology at the 2019 American Society of Hematology (ASH) meeting in Orlando Florida, December 7-10.

10 Dec 2019

Combination therapy is safe and effective for older patients diagnosed with acute lymphoblastic leukemia

A study led by The University of Texas MD Anderson Cancer Center showed that treatment combining lower doses of chemotherapy with the monoclonal antibody inotuzumab ozogamicin (INO), with or without the drug blinatumomab, is safe and effective in patients over 60 years of age who were newly diagnosed with a high-risk form of acute lymphoblastic leukemia (ALL) known as Philadelphia chromosome-negative ALL.

10 Dec 2019

Rutgers researchers identify small mutations for AML and MDS through deep DNA sequencing

Deep DNA sequencing analysis conducted by Rutgers Cancer Institute of New Jersey investigators examining genomic differences within tumors for prediction of disease relapse in certain hematologic malignancies has identified small mutations.

9 Dec 2019

New strategies needed to manage ibrutinib-related toxicities in CLL patients, study suggests

New findings by Yale Cancer Center and Smilow Cancer Hospital researchers show that as the use of the drug ibrutinib climbs in patients with chronic lymphocytic leukemia, so do the rates of patients who stop taking the drug.

9 Dec 2019

Pairing chemotherapy azacitidine with enasidenib boosts complete remission in AML patients

A multi-institutional, Phase II study led by The University of Texas MD Anderson Cancer Center showed that pairing standard chemotherapy azacitidine (AZA) with a drug called enasidenib (ENA) measurably boosts complete remission in patients newly diagnosed with a specific form of acute myeloid leukemia (AML).

9 Dec 2019

Yale study highlights the need to develop effective, less toxic approaches to treat AML patients

A new study by Yale Cancer Center researchers shows understanding treatment patterns for patients with acute myeloid leukemia is vital to develop strategies to improve outcomes.

9 Dec 2019

Thermo Fisher Scientific to accelerate genomic profiling process in hematology and oncology labs

Clinical researchers who take a traditional sequential approach to analyze myeloid malignancies, a highly heterogeneous group of disorders, face a major hurdle: a laborious and time-consuming workflow.

From Thermo Fisher Scientific Inc. 9 Dec 2019

Adding venetoclax to transplant conditioning regimen shows promise in patients with myeloid cancers

For patients with high-risk myeloid cancers undergoing a donor stem cell transplant, adding the targeted drug venetoclax to a reduced-intensity drug regimen prior to transplant is safe and does not impair the ability of the donor cells to take root in recipients' bodies, a study led by Dana-Farber Cancer Institute researchers suggests.

8 Dec 2019

Genetic features of AML in older patients can predict outcomes after stem cell transplant

For older patients with acute myeloid leukemia, the prospects for success of a stem cell transplant can often be predicted based on the particular set of genetic mutations within the tumor cells, investigators at Dana-Farber Cancer Institute and other research centers will report today at the 61st American Society of Hematology (ASH) Annual Meeting.

8 Dec 2019

Ibrutinib-based therapy provides superior clinical outcomes in majority of CLL patients

The ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) today announced results from an extended follow-up analysis of patients in its randomized Phase 3 clinical trial, E1912.

8 Dec 2019

New technique holds promise in cancer research and science studies

A new technique reported this week in Science overcomes several limitations of typical high-throughput chemical screens conducted on cell samples. Such screens are commonly used to try to discover new cancer drugs, and in many other biomedical applications.

8 Dec 2019

Researchers discover potent next generation of drugs to fight leukemia and lymphoma

UT Health San Antonio researchers, working with collaborators at the University of Florida, have discovered a safe and potent next generation of drugs to fight multiple types of leukemia and lymphoma in adults and children.

6 Dec 2019

New approach can improve the activity of CAR-T cells against blood and solid cancers

A new approach to programing cancer-fighting immune cells called CAR-T cells can prolong their activity and increase their effectiveness against human cancer cells grown in the laboratory and in mice, according to a study by researchers at the Stanford University School of Medicine.

5 Dec 2019

A major step toward preventing GvHD in patients receiving bone marrow transplants

A drug used for rheumatoid arthritis has moved a step closer to FDA approval for a desperately needed new use.

4 Dec 2019

Michigan dermatologists honored for diagnosing rare condition

The American Academy of Dermatology has honored board-certified dermatologists Steven Daveluy, MD, FAAD, and Benjamin Workman, MD, FAAD, as Patient Care Heroes for their teamwork with oncologists to diagnose a rare condition affecting just one in a million patients, known as drug-induced hypersensitivity syndrome.

4 Dec 2019

Leukemia News and Research

Further Reading

Study provides most detailed classification of acute myeloid leukemia, myelodysplastic syndrome

Researchers aim to exploit DNA mutations in the treatment of blood and bone marrow cancers

Transplant patient finds out his DNA has been replaced by that of his donor

Immunotherapy more effective than chemotherapy for children, young adults with relapsed B-ALL

Risk of specific genetic translocation is higher in patients of African ancestry, shows study

Scientists highlight the benefits of Droplet Digital PCR technology at the 2019 ASH meeting

Combination therapy is safe and effective for older patients diagnosed with acute lymphoblastic leukemia

Rutgers researchers identify small mutations for AML and MDS through deep DNA sequencing

New strategies needed to manage ibrutinib-related toxicities in CLL patients, study suggests

Pairing chemotherapy azacitidine with enasidenib boosts complete remission in AML patients

Yale study highlights the need to develop effective, less toxic approaches to treat AML patients

Thermo Fisher Scientific to accelerate genomic profiling process in hematology and oncology labs

Adding venetoclax to transplant conditioning regimen shows promise in patients with myeloid cancers

Genetic features of AML in older patients can predict outcomes after stem cell transplant

Ibrutinib-based therapy provides superior clinical outcomes in majority of CLL patients

New technique holds promise in cancer research and science studies

Researchers discover potent next generation of drugs to fight leukemia and lymphoma

New approach can improve the activity of CAR-T cells against blood and solid cancers

A major step toward preventing GvHD in patients receiving bone marrow transplants

Michigan dermatologists honored for diagnosing rare condition

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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