Preclinical News and Research

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Protein encoded by the ASPN gene plays a protective role in pulmonary arterial hypertension

A new study from researchers with UCLA Health and collaborating organizations has found that asporin, a protein encoded by the ASPN gene, plays a protective role in pulmonary arterial hypertension (PAH).

21 Aug 2024

New compound shows promise in Alzheimer’s preclinical models

A multidisciplinary team of scientists led by Kurt Brunden, Ph.D., at the University of Pennsylvania Perelman School of Medicine, and Carlo Ballatore, Ph.D., at University of California San Diego, has been awarded a $6.9 million grant from the National Institute on Aging (NIA) to prepare a potential disease-modifying Alzheimer's treatment for future clinical trials.

21 Aug 2024

New fluorescent probe offers non-invasive detection of smell loss

A new fluorescent imaging probe can for the first time objectively and non-invasively measure loss of smell, clinically known as anosmia.

20 Aug 2024

Gut microbiome discovery paves the way for new heart failure treatments

Cleveland Clinic researchers have made a significant discovery about how the gut microbiome interacts with cells to cause cardiovascular disease.

20 Aug 2024

NIH awards $6.9 million to prepare a potential Alzheimer's treatment for future clinical trials

A multidisciplinary team of scientists led by Carlo Ballatore, Ph.D., at University of California San Diego and Kurt Brunden, Ph.D., at the University of Pennsylvania has been awarded a $6.9 million grant from the National Institute on Aging (NIA) to prepare a potential disease-modifying Alzheimer's treatment for future clinical trials.

20 Aug 2024

AI-powered Surreal-GAN identifies diverse brain aging patterns

Researchers utilize ‘Surreal-GAN,’ a deep-representation learning model, to examine the heterogeneity of aging brains.

20 Aug 2024

New project aims to study the combination of two therapies for pediatric brain cancer

Natasha Sheybani, assistant professor of biomedical engineering at the University of Virginia School of Engineering, will collaborate with researchers at Children's National Hospital to study the combination of two therapies for pediatric brain cancer.

19 Aug 2024

Weill Cornell Medicine secures $12.4 million grant for lymphoma research

Weill Cornell Medicine has received a five-year, $12.4 million grant from the National Cancer Institute, part of the National Institutes of Health, for an extensive program of basic and translational research on the biology of diffuse large B-cell lymphoma (DLBCL), the most common form of lymphoma.

15 Aug 2024

Engineering extracellular vesicles for potential treatment of type 1 diabetes

Within each of us lies an army of cells whose topmost duty is protecting against external pathogens and internal threats such as proliferating cancer cells.

14 Aug 2024

Can psychological wellbeing predict cognitive impairment?

Whether changes in psychological wellbeing trajectories precede mild cognitive impairment (MCI) and dementia.

14 Aug 2024

Mayo Clinic pioneers use of pulsed field ablation to treat atrial fibrillation

Cardiologists in Mayo Clinic's Heart Rhythm Clinic are using a new innovative energy source to safely and successfully treat a common type of heart arrhythmia.

13 Aug 2024

Engineered NK cells with IL-21 show strong antitumor activity against glioblastoma

Natural killer (NK) cells engineered to express interleukin-21 (IL-21) demonstrated sustained antitumor activity against glioblastoma stem cell-like cells (GSCs) both in vitro and in vivo, according to new research from The University of Texas MD Anderson Cancer Center.

12 Aug 2024

New study links brain cell structures to memory loss in aging and dementia

Researchers assessed whether dendritic spine head diameter in the temporal cortex is a better predictor of episodic memory performance in older adults than synapse quantity, accounting for β amyloid plaques, neurofibrillary tangles, and sex.

12 Aug 2024

Brain circuits connecting stress to gut bacteria reveal new pathways for immune regulation

Researchers have discovered a brain-gut circuit that links stress to changes in gut bacteria, revealing that emotional states can directly influence immune function through the duodenal glands.

11 Aug 2024

EZH2's role in cancer progression and therapy explored

Enhancer of zeste homolog 2 (EZH2) is a catalytic subunit of the Polycomb-repressive complex 2 (PRC2), which plays a crucial role in transcriptional repression through the methylation of histone H3 on lysine 27 (H3K27me3).

9 Aug 2024

Rare but real: The neurological risks associated with vaccines

Review highlights the rare neurological risks associated with vaccination, emphasizing the importance of accurate detection and management strategies, particularly in the context of the COVID-19 pandemic.

9 Aug 2024

Insilico Medicine's pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced ISM6331, potential best-in-class pan-TEAD inhibitor, has received the U.S. Food and Drug Administration (FDA) Investigational New Drug (IND) clearance for the treatment of mesothelioma, following the grant of Orphan Drug Designation (ODD) in June 2024. It brings the total number of IND-approved molecules of Insilico to nine.

8 Aug 2024

New insights into the role of cancer-associated fibroblasts in promoting lymphatic metastasis

Lymph node metastasis is a crucial factor in cancer progression, significantly affecting patient prognosis and treatment outcomes.

8 Aug 2024

Zebrafish model reveals how BCG vaccine triggers immune response in bladder cancer

Using zebrafish "Avatars", an animal model developed by the Cancer Development and Innate Immune Evasion lab at the Champalimaud Foundation (CF), led by Rita Fior, Mayra Martínez-López – a former PhD student at the lab now working at the Universidad de las Américas in Quito, Ecuador – and colleagues studied the initial steps of the Bacillus Calmette-Guérin (BCG) vaccine's action on bladder cancer cells.

8 Aug 2024

Review of fasting-mimicking diets in cancer treatment

Researchers present the role of cyclic fasting and fasting-mimicking diets (FMD) in cancer therapy.

8 Aug 2024

Preclinical News and Research

Protein encoded by the ASPN gene plays a protective role in pulmonary arterial hypertension

New compound shows promise in Alzheimer’s preclinical models

New fluorescent probe offers non-invasive detection of smell loss

Gut microbiome discovery paves the way for new heart failure treatments

NIH awards $6.9 million to prepare a potential Alzheimer's treatment for future clinical trials

AI-powered Surreal-GAN identifies diverse brain aging patterns

New project aims to study the combination of two therapies for pediatric brain cancer

Weill Cornell Medicine secures $12.4 million grant for lymphoma research

Engineering extracellular vesicles for potential treatment of type 1 diabetes

Can psychological wellbeing predict cognitive impairment?

Mayo Clinic pioneers use of pulsed field ablation to treat atrial fibrillation

Engineered NK cells with IL-21 show strong antitumor activity against glioblastoma

New study links brain cell structures to memory loss in aging and dementia

Brain circuits connecting stress to gut bacteria reveal new pathways for immune regulation

EZH2's role in cancer progression and therapy explored

Rare but real: The neurological risks associated with vaccines

Insilico Medicine's pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment

New insights into the role of cancer-associated fibroblasts in promoting lymphatic metastasis

Zebrafish model reveals how BCG vaccine triggers immune response in bladder cancer

Review of fasting-mimicking diets in cancer treatment

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