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Advanced paternal age associated with risk of neurodevelopmental disorders in children

It is no secret that genetic factors play a role in determining whether children have neurodevelopmental disorders. Maternal exposure to drugs and viral or bacterial illnesses can be detrimental too.

21 Apr 2020

Bio-Rad Introduces Anti-Ipilimumab Antibodies

Bio-Rad Laboratories, Inc has extended its range of recombinant monoclonal anti-idiotypic antibodies.

21 Apr 2020

COVID-19 and immunodeficiency

COVID-19 disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a highly infectious disease. As of today, over 170,000 people worldwide have succumbed to the infection. Reports have shown that some comorbidities and illnesses raise the risk of getting infected and also influence the severity of the disease. Having a compromised immune system can also drastically raise the risk of getting COVID-19.

21 Apr 2020

Role of ACE/ARB inhibitors in the treatment of COVID-19

A new opinion piece published in the journal Circulation Research in April 2020 defends the use of antihypertensive drugs called ACE inhibitors and ARBs in patients with pandemic viral pneumonia called COVID-19.

20 Apr 2020

Discovery could open door to the development of new anti-cancer drugs

A team of scientists led by the University of Michigan Rogel Cancer Center and Case Comprehensive Cancer Center has identified the binding site where drug compounds could activate a key braking mechanism against the runaway growth of many types of cancer.

20 Apr 2020

Mutations in novel coronavirus make it more dangerous

A new report published on the preprint server medRxiv in April 2020 reveals that the novel coronavirus SARS-CoV-2 shows the presence of new mutations acquired within infected human cases, which significantly increase its ability to cause human disease.

20 Apr 2020

Scientists delay onset of amyotrophic lateral sclerosis in mice

A team of researchers led by scientists at the University of Toronto has delayed the onset of amyotrophic lateral sclerosis in mice.

20 Apr 2020

Do ACE inhibitors increase SARS-CoV-2 binding to ACE2?

The COVID-19 pandemic has forced clinicians and academicians to intensive research to find evidence for many conventional therapies. A new round-up editorial published in the journal Cardiovascular Research in April 2020 summarizes the current clinical grounds for and against the use of the commonly used angiotensin axis inhibitors in patients with COVID-19.

20 Apr 2020

HIV-1 and influenza antivirals not effective for treating mild-to-moderate COVID-19 cases

An exploratory randomized, controlled study on the safety and efficacy of either lopinavir/ritonavir (LPV/r) or Arbidol--antivirals that are used in some countries against HIV-1 and to treat influenza , respectively--as treatments for COVID-19, the disease caused by the novel coronavirus SARS-CoV-2, suggests that neither drug improves the clinical outcome of patients hospitalized with mild-to-moderate cases of the disease over supportive care.

20 Apr 2020

A novel method for predicting promising antiviral drug or vaccine targets

A novel method to predict the most promising targets for antiviral drugs or vaccines is based on the conformational changes viral glycoproteins go through during the process of recognition and binding to the host cell.

20 Apr 2020

Analysis reveals cocktail of pharmaceuticals in the waters of Bangladesh

In spring of 2019, researchers set out to investigate what chemicals could be found in the waters of Bangladesh.

20 Apr 2020

Artificial 'candy canes' block viral entry and infection

Viruses are part of the human experience throughout our lives. They cause lots of different illnesses with the current coronavirus pandemic as just one example.

20 Apr 2020

Study reveals new therapeutic options for multiple sclerosis

Multiple sclerosis is known as "the disease with a thousand faces" because symptoms and progression can vary dramatically from patient to patient.

20 Apr 2020

A new combinatorial therapy for treatment of liver cancer

In the latest issue of Molecular Therapy, Skoltech and MIT researchers have published a new combinatorial therapy for the treatment of liver cancer.

20 Apr 2020

Activating a braking mechanism against cancer

A team has identified the binding site where drug compounds could activate a braking mechanism against runaway growth of cancer.

20 Apr 2020

Potential new therapies for multiple sclerosis

In every MS patient cells of their body's own immune system migrate to the brain, where they destroy the myelin sheath.

20 Apr 2020

Wavelength Pharmaceuticals expands supplies of key drug ingredients for critically ill COVID-19 patients

Wavelength Pharmaceuticals, a leading supplier of active pharmaceutical ingredients, today reported that it has greatly expanded production of APIs for certain pharmaceutical products needed to manage respiratory critical care patients.

20 Apr 2020

Amid pandemic, FDA seizes cheaper drugs from Canada

The Food and Drug Administration in the past month has stepped up seizures of prescription drugs being sent to American customers from pharmacies in Canada and other countries, according to operators of stores in Florida that facilitate the transactions.

20 Apr 2020

Remdesivir prevents COVID-19 progression to severe pneumonia, animal study shows

A team of scientists at the National Institute of Allergy and Infectious Diseases, which is part of the U.S. National Institutes of Health, has tested the efficacy of remdesivir, a nucleotide analog prodrug with a broad antiviral activity, as a COVID-19 treatment.

20 Apr 2020

Scientists unveil novel coronavirus variants in India

The global coronavirus disease COVID-19 pandemic is ravaging the world, affecting 185 countries and territories and infecting 2.4 million people. Now, a team of scientists aims to shed light on the variants of the novel coronavirus strains in India, showing how changes correspond to its transmission and how it causes disease.

19 Apr 2020