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Targeted therapy shows immense benefit for patients with early stage NSCLC

According to findings led by researchers at Yale Cancer Center, treatment with the targeted therapy osimertinib following surgery significantly improves disease-free survival (DFS) in patients with early-stage, non-small cell lung cancer (NSCLC) with EGFR gene mutations.

29 May 2020

Radiation and surgery do not prolong survival in newly diagnosed metastatic breast cancer

Up to now, women who present with a new diagnosis of breast cancer that is already in an advanced stage (stage IV) face an unanswered question about whether surgery and radiation to the tumor in the breast (local therapy) will prolong survival compared to the traditional treatment of systemic treatment alone.

29 May 2020

SwRI receives $1.9 million to identify potential treatments for COVID-19

Using Department of Defense supercomputers, Southwest Research Institute is virtually screening millions of drug compounds to search for and test possible treatment options for the novel coronavirus 2019.

29 May 2020

5-day Remdesivir dose works as well as the 10-day dose in COVID-19, study finds

With more than 5.8 million people infected with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the search is on for an effective SARS-CoV-2 vaccine or drug to treat COVID-19 disease.

28 May 2020

Ludwig Cancer Research study profiles immune landscape of brain tumors

A Ludwig Cancer Research study has profiled, in a sweeping comparative analysis, the distinct immune landscapes of tumors that arise in the brain, or gliomas, and those that metastasize to the organ from the lungs, breast and skin.

28 May 2020

Dual-pathway approach can lead to better outcomes in patients with heart stents

Pairing a blood-thinning drug with aspirin daily for patients who have an angioplasty with a stent can contribute to better health outcomes, including lower risk of death, than aspirin alone, according to a recent study by cardiologists at the University of Alberta and Mazankowski Alberta Heart Institute.

28 May 2020

Nanoscope received NIH grant to advance ultrafast laser-based gene delivery to the retina

The Nanoscope team has developed Multi-Characteristic Opsins to sensitize cells toward low level of white light so that vision is improved at ambient room light.

28 May 2020

Combination therapy found to be effective against IDH1-mutated acute myeloid leukemia

A combination therapy of ivosenidib (IVO) plus venetoclax (VEN) with or without azacitidine (AZA) was found to be effective against a specific genetic subtype of acute myeloid leukemia (AML) in a Phase Ib/II trial led by researchers at The University of Texas MD Anderson Cancer Center.

28 May 2020

Targeted drugs shrink breast cancer tumors in mice without toxic side effects

A team of researchers led by Worcester Polytechnic Institute Provost Wole Soboyejo has identified targeted drugs that reduced the sizes of hard-to-treat breast cancer tumors in mice without inducing the toxic side effects that are typically associated with conventional chemotherapy.

28 May 2020

Pitt researcher to explore the neurological sex-based divide in dementia

Fifty million people worldwide are living with dementia, a broad term for diseases and conditions characterized by progressive cognitive decline.

28 May 2020

Inhibiting tumor signals can suppress the spread of cancer

For most people who die of cancer, the spread of the initial tumor is to blame. "Metastasis is what kills most cancer patients," says Serge Fuchs, a professor in Penn's School of Veterinary Medicine.

28 May 2020

New drug combinations could help overcome genetic immunotherapy resistance

A new study from researchers at the UCLA Jonsson Comprehensive Cancer Center helps explain how disruptions in genes can lead to the resistance to one of the leading immunotherapies, PD-1 blockade, and how new drug combinations could help overcome resistance to the anti-PD-1 therapy in a mechanistically-based way.

28 May 2020

Transgenic mouse model of HLH may play key role in saving lives during COVID-19

A transgenic mouse developed at Cincinnati Children's to model the deadly childhood immune disease HLH (hemophagocytic lymphohistiocytosis) may play a key role in saving lives during the COVID-19 virus pandemic.

28 May 2020

Clinical study shows promising results for treatment of VHL disease-associated renal tumors

In an international trial led by researchers at The University of Texas MD Anderson Cancer Center, treatment with MK-6482, the small molecule inhibitor of hypoxia-inducible factor (HIF)-2a was well tolerated and resulted in clinical responses for patients with von Hippel-Lindau disease (VHL)–associated renal cell carcinoma.

28 May 2020

New framework for assessing and managing people with serious spinal pathologies

Rehabilitation clinicians and other health care professionals now have a framework for assessing and managing people who may have serious spinal pathologies.

28 May 2020

PKU-led team identifies potent neutralizing antibodies against SARS-CoV-2

A joint research team led by Sunney Xie, Director of Beijing Advanced Innovation Center for Genomics at Peking University has successfully identified multiple highly potent neutralizing antibodies against the novel coronavirus SARS-CoV-2, the causative virus of the respiratory disease COVID-19, from convalescent plasma by high-throughput single-cell sequencing.

28 May 2020

Frog brain discovery may pave the way for repairing birth defects in humans

A team of researchers from Tufts University, Universitat de Valencia, and Harvard University has discovered that the brains of developing frog embryos damaged by nicotine exposure can be repaired by using “ionoceuticals” that can help in the recovery of bioelectric patterns in the embryo.

28 May 2020

Is vitamin D really linked to excess COVID-19 mortality?

The ongoing COVID-19 pandemic has caused many deaths, numbering in the hundreds of thousands, over many different countries. However, the reasons for the differential mortality from region to region are far from clear, despite intensive research.

27 May 2020

Study finds large racial/ethnic differences in use of medication for OUD during pregnancy

Black non-Hispanic and Hispanic women with opioid use disorder are significantly less likely to receive or to consistently use any medication to treat their opioid use disorder during pregnancy than their white non-Hispanic counterparts, according to a new study from Massachusetts General Hospital.

27 May 2020

Researchers develop promising immunotherapy treatment for glioblastoma

Researchers of McMaster University and the University of Toronto have developed a promising immunotherapy treatment for a deadly form of adult brain cancer called glioblastoma.

27 May 2020