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Discovery of human cell signaling systems using bioinformatics

There are many and various receptors on the surface of each human cell, which bind to specific molecules called ligands, to set off signals that modulate cell activity accordingly. These pathways are exploited by therapeutic drugs. In fact, one in three drugs makes use of receptors belonging to a single very large family – the GPCR (G protein receptor coupled receptor) family.

1 Nov 2019

UI scientists are developing new delivery tools for gene editing

News of advances in gene-editing technology raises the prospect of actually using this approach to treat disease in patients. But one of the hurdles that remains is how to deliver these tools to the right cells in the patients safely and efficiently.

31 Oct 2019

Study findings may shed new light on the etiology of Alzheimer's disease

New research suggests that the complex meshwork of proteins and potentially other biomolecules that provides structural and biochemical support to surrounding cells in the brain may play an important role in Alzheimer's disease.

31 Oct 2019

New signaling systems discovered in human cells

The human cell has a wide variety of receptors on its surface that many molecules and therapeutic drugs can bind to in order to activate signals inside the cell to regulate different physiological functions. GPCRs are the largest - and a very important - family of receptors on human cells.

31 Oct 2019

Researchers develop new therapeutic concept for treatment of temporal lobe epilepsy

Teams of researchers from Charité - Universitätsmedizin Berlin and the Medical University of Innsbruck have developed a new therapeutic concept for the treatment of temporal lobe epilepsy.

30 Oct 2019

CEM enters into a definitive agreement to purchase key assets of Intavis Bioanalytical Instruments

CEM Corporation today announced that it has entered into a definitive agreement to purchase the instrumentation lines of Intavis Bioanalytical Instruments AG, with headquarters in Cologne Germany. The acquisition allows CEM to strengthen its product offering in the Life Sciences for proteomics, in-situ hybridization and particularly in the field of peptide synthesis.

From CEM Corporation - Life Science 30 Oct 2019

New technique could replace conventional methods of testing paralytic neurotoxins

Animal testing will no longer be required to assess a group of deadly neurotoxins, thanks to University of Queensland-led research.

30 Oct 2019

Celiac disease may now be curable with biodegradable nanoparticles

A phase 2 trial just concluded shows that people with celiac disease may now be able to hope for a cure, through a treatment that makes the immune system tolerant towards gluten. This could eventually make it possible for such individuals to eat gluten-containing foods without fear.

22 Oct 2019

Scientists develop more accurate method to find good targets for cancer immunotherapy

Ludwig Cancer Research scientists have developed a new and more accurate method to identify the molecular signs of cancer likely to be presented to helper T cells, which stimulate and orchestrate the immune response to tumors and infectious agents.

15 Oct 2019

Simpler and direct method for producing lipidated proteins

Some of the body's proteins are not just made up of amino acids, they are also 'decorated' with lipid chains, which significantly influence the biological functions of the protein.

15 Oct 2019

Ludwig scientists develop robust method to refine personalized cancer immunotherapy

14 Oct 2019

Simple way to effectively transport medication into the brain identified

For the first time, scientists have identified a simple way that can effectively transport medication into the brain - which could lead to improved treatments for neurological and neurodegenerative diseases.

11 Oct 2019

UD engineering professor receives NIH grant to accelerate study of lung fibrosis

University of Delaware Professor April Kloxin has been awarded a National Institutes of Health Director's New Innovator Award from the NIH Common Fund's High-Risk, High-Reward Research program, which supports highly innovative research proposals.

9 Oct 2019

Pepscan announces increased GMP production capacity to facilitate clients' growth

Today, Pepscan announced that its GMP production capacity has doubled. Pepscan is an all-in-one partner in peptides, building on 25 years of experience in advancing and applying peptide expertise to facilitate clients in the development and production of peptides.

9 Oct 2019

HIV-1 Tat expression leads to perturbations in cellular protein expression, research suggests

The cover for issue 54 of Oncotarget features Figure 2, "Comparative proteomic profiling of the peptides/proteins identified from 293T, IL16lamp2b and mExo-Tat samples," by Lu, et al.

4 Oct 2019

New defensive mechanism against bacterial wound infections discovered

Wound inflammation which results in impaired wound healing can have serious consequences for patients. Researchers from Charité - Universitätsmedizin Berlin have discovered a new defensive mechanism which enables our skin to actively kill bacteria.

4 Oct 2019

Researchers are developing new therapy to counter the effects of traumatic brain injury

A blow to the head or powerful shock wave on the battlefield can cause immediate, significant damage to a person's skull and the tissue beneath it.

4 Oct 2019

Chemical-sensing cells in the gums protect the mouth from infections

Newly discovered chemical-sensing cells in the gums protect the mouth by standing guard against infections that damage soft tissue and destroy the bone that supports the teeth, report researchers from the Monell Chemical Senses Center in an animal study published this week in Nature Communications.

3 Oct 2019

Discovery of neoantigens could widen the possibilities for universal cancer vaccine

For more than a decade, scientist Stephen Albert Johnston and his team at Arizona State University's Biodesign Institute have pooled their energies into an often scoffed-at, high-risk, high-reward goal in medicine: to develop a universal vaccine to prevent cancer.

2 Oct 2019

UC Davis research team receives NIH grant to develop novel drugs for treating pain

A UC Davis research team, led by Vladimir Yarov-Yarovoy and Heike Wulff, will receive a $1.5 million grant from the National Institutes of Health to develop a novel class of peptides that are better at treating pain and don't have the side effects of opioids.

1 Oct 2019

Peptides News and Research

Discovery of human cell signaling systems using bioinformatics

UI scientists are developing new delivery tools for gene editing

Study findings may shed new light on the etiology of Alzheimer's disease

New signaling systems discovered in human cells

Researchers develop new therapeutic concept for treatment of temporal lobe epilepsy

CEM enters into a definitive agreement to purchase key assets of Intavis Bioanalytical Instruments

New technique could replace conventional methods of testing paralytic neurotoxins

Celiac disease may now be curable with biodegradable nanoparticles

Scientists develop more accurate method to find good targets for cancer immunotherapy

Simpler and direct method for producing lipidated proteins

Ludwig scientists develop robust method to refine personalized cancer immunotherapy

Simple way to effectively transport medication into the brain identified

UD engineering professor receives NIH grant to accelerate study of lung fibrosis

Pepscan announces increased GMP production capacity to facilitate clients' growth

HIV-1 Tat expression leads to perturbations in cellular protein expression, research suggests

New defensive mechanism against bacterial wound infections discovered

Researchers are developing new therapy to counter the effects of traumatic brain injury

Chemical-sensing cells in the gums protect the mouth from infections

Discovery of neoantigens could widen the possibilities for universal cancer vaccine

UC Davis research team receives NIH grant to develop novel drugs for treating pain

Editorial Focus eBook - Peptides and Oligonucleotides (2nd edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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