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Deciphering immunological imprinting in the context of COVID-19

In a recent article published in the journal Immunity, researchers explained the concept of immunological imprinting and its underlying principles. They also discussed its potential role in the context of coronavirus disease 2019 (COVID-19) vaccines.

24 Apr 2023

Researchers develop a backpack-based myeloid cell therapy for MS patients

Multiple sclerosis (MS) is a devastating autoimmune disease that destroys the protective myelin covering around nerves, disrupting communication between the brain and body, and causing patients' ability to move and function to progressively decline.

21 Apr 2023

Study identifies various biomarkers of moderate alcohol intake and alcoholic beverages

Researchers determined and validated ethanol intake biomarkers that can be used to accurately assess alcohol intake.

21 Apr 2023

Brain's glucose metabolism: Key to unlocking new therapies for Alzheimer's and Parkinson's

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20 Apr 2023

Omicron spike N679K mutation acts as a loss-of-function mutation attenuating SARS-CoV-2 in vitro & in vivo

Researchers explored the impact of a loss-of-function mutation in the SARS-CoV-2 Omicron variants on the expression of the spike protein.

20 Apr 2023

Study indicates that SARS-CoV-2 has evolved to gain increased replicative fitness and become well-adapted in epithelial cells of human airways

Researchers explored increasing replicative fitness of emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants

20 Apr 2023

Protein OCLN found to play crucial role in SARS-CoV-2 cell-to-cell transmission

Research explains how the SARS-CoV-2 virus spreads efficiently by directly infecting neighboring cells through a process called cell-to-cell transmission. The virus uses a protein called occludin (OCLN) to enter the cells and causes syncytium formation, which leads to viral spread.

20 Apr 2023

Researchers compare the action of natural and therapeutic opioids

The human body naturally produces opioid-like substances, such as endorphins, which block the perception of pain and increase the feeling of well-being.

19 Apr 2023

Unlocking the potential of RNA lipid nanoparticles to revolutionize cancer treatment

This paper discusses the use of RNA lipid nanoparticles for cancer immunotherapy, which has shown promising results in clinical use. However, only a small percentage of patients respond to existing immunotherapies, and the paper explores opportunities for improvement.

18 Apr 2023

Can a disrupted gut microbiota contribute to anorexia nervosa pathogenesis?

Research investigates whether a disrupted gut microbiota contributes to anorexia nervosa pathogenesis. The study found that a disruptive gut microbiome may contribute to anorexia nervosa pathogenesis.

18 Apr 2023

Study reveals DCAF1 protein's role in colon cancer development through EZH2 phosphorylation

A recent study reveals that DCAF1 is overexpressed and phosphorylates EZH2 in colon cancer cells.

18 Apr 2023

Edible mushrooms: the role of antioxidant compounds as potential candidates for neurodegenerative disease prevention and treatment

Researchers evaluated whether edible mushrooms aid in preventing neurodegenerative diseases.

18 Apr 2023

New PET imaging breakthrough offers potential Alzheimer's diagnosis and treatment breakthrough

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16 Apr 2023

How SARS-CoV-2 Omicron subvariants have evolved to evade host T-cell immunity

Researchers investigate whether SARS-CoV-2 and its variants have evolved to evade CD8+ T cell-mediated immunity.

15 Apr 2023

AI-designed T-cell vaccine extremely effective at preventing severe COVID-19 in mice

The current COVID-19 vaccines are designed to trigger an antibody response to the SARS-CoV-2 spike protein, which is vulnerable to mutations that could make the vaccine less effective over time.

13 Apr 2023

New organoid platform could make vaccine screening quicker and greatly reduce animal testing

Developing and testing new treatments or vaccines for humans almost always requires animal trials, but these experiments can sometimes take years to complete and can raise ethical concerns about the animals' treatment.

12 Apr 2023

UH researcher examines the causes of skeletal muscle atrophy

Skeletal muscle atrophy, or wasting, is a devastating and often irreversible syndrome during the aging process and for patients with advanced cancer.

11 Apr 2023

SARS-CoV-2 may exploit multiple receptors and pathways across various tissues, age groups

A study led by Mount Sinai researchers Dr. Bin Zhang, the Willard T.C. Johnson Research Professor of Neurogenetics, and Dr. Christian Forst, an Associate Professor in the Department of Genetics and Genomic Sciences, have identified potential novel receptors for SARS-CoV-2 and unveiled their tissue-specific and age-dependent expression.

11 Apr 2023

The detrimental effects of excessive carbonated drink consumption on dental health

Researchers evaluated the detrimental effects of excessive consumption of carbonated drinks on dental health.

11 Apr 2023

Regulatory T cell populations descend from two different origins, finds study

A regulatory class of human T cells descends from two different origins, one that relates to autoimmunity and one that relates to protective immunity, according to a new study led by Children's Hospital of Philadelphia (CHOP).

7 Apr 2023

in vivo News and Research

Deciphering immunological imprinting in the context of COVID-19

Researchers develop a backpack-based myeloid cell therapy for MS patients

Study identifies various biomarkers of moderate alcohol intake and alcoholic beverages

Brain's glucose metabolism: Key to unlocking new therapies for Alzheimer's and Parkinson's

Omicron spike N679K mutation acts as a loss-of-function mutation attenuating SARS-CoV-2 in vitro & in vivo

Study indicates that SARS-CoV-2 has evolved to gain increased replicative fitness and become well-adapted in epithelial cells of human airways

Protein OCLN found to play crucial role in SARS-CoV-2 cell-to-cell transmission

Researchers compare the action of natural and therapeutic opioids

Unlocking the potential of RNA lipid nanoparticles to revolutionize cancer treatment

Can a disrupted gut microbiota contribute to anorexia nervosa pathogenesis?

Study reveals DCAF1 protein's role in colon cancer development through EZH2 phosphorylation

Edible mushrooms: the role of antioxidant compounds as potential candidates for neurodegenerative disease prevention and treatment

New PET imaging breakthrough offers potential Alzheimer's diagnosis and treatment breakthrough

How SARS-CoV-2 Omicron subvariants have evolved to evade host T-cell immunity

AI-designed T-cell vaccine extremely effective at preventing severe COVID-19 in mice

New organoid platform could make vaccine screening quicker and greatly reduce animal testing

UH researcher examines the causes of skeletal muscle atrophy

SARS-CoV-2 may exploit multiple receptors and pathways across various tissues, age groups

The detrimental effects of excessive carbonated drink consumption on dental health

Regulatory T cell populations descend from two different origins, finds study

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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