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Long-lasting B cells do not recognize emerging SARS-CoV-2 variants, shows study

A new analysis of B cells and more than 1,000 different monoclonal antibodies from 8 patients with COVID-19 shows that, contrary to previous hypotheses, protective B cell responses to the SARS-CoV-2 spike protein remain stable and continue to evolve over a 5-month period, many months after the initial period of active viral replication.

23 Feb 2021

COVID-19 may alter host proteins to cause autoimmunity

To better understand the transient and chronic autoimmune symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, researchers from Memorial Sloan Kettering Cancer Center, Guizhou Medical University, and biotech company Curandis embarked on an endeavor to establish a comprehensive autoantigenome for COVID19.

23 Feb 2021

SARS-CoV-2 variants emerge during humoral immunity phase of acute COVID-19

A new preprint research paper posted to the bioRxiv server reports the rapid emergence of variants within an infected individual. The evolution of the virus within an infected host is not excluded by the close similarity between the consensus sequences of single-person SARS-CoV-2, since the number of viral copies is at its peak soon after infection occurs and before the host develops adaptive immunity.

23 Feb 2021

Two potent SARS-CoV-2 neutralizing antibodies effective against B.1.351 and B.1.1.7 variants

By analyzing the cryoEM structures of antibodies against the SARS-CoV-2 virus, researchers report that the neutralizing capabilities of two antibodies are not affected by new strains as these antibodies target regions of the virus away from the ACE2 binding regions.

23 Feb 2021

New guidelines aim to help reduce blood pressure for chronic kidney disease patients

A recommendation for more intensive blood pressure management from an influential global nonprofit that publishes clinical practice guidelines in kidney disease could, if followed, benefit nearly 25 million Americans, according to an analysis led by researchers at the Johns Hopkins Bloomberg School of Public Health.

23 Feb 2021

Research predicts which mammal species can spread SARS-CoV-2

Scientists worldwide are fighting to contain the ongoing COVID-19 pandemic, which has already claimed more than 2.48 million lives. Preventing spillback infections is essential to containing the pandemic. To do so, it is vital to understand the nature of the virus, i.e., its susceptibility to a range of hosts.

23 Feb 2021

Phase 1 clinical trial shows promising results for monoclonal antibodies against MERS coronavirus

A randomized, placebo-controlled Phase 1 clinical trial of two monoclonal antibodies (mAbs) directed against the coronavirus that causes Middle East respiratory syndrome (MERS) found that they were well tolerated and generally safe when administered simultaneously to healthy adults.

23 Feb 2021

Key mutation sites in the SARS-CoV-2 spike protein modulate antibody and ACE2 affinity

A paper recently uploaded to the preprint server bioRxiv by researchers at Chapman University in California (Feb 22nd, 2021) utilized computational methods to screen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutants for affinity with the angiotensin-converting enzyme 2 (ACE2) receptor and monoclonal antibodies REG10987 and REG10933.

23 Feb 2021

SARS-CoV-2 mutations allow escape from clinical monoclonal antibodies

A new research paper recently uploaded to the preprint server bioRxiv by Jesse D. Bloom et al. (22nd Feb 2021) aims to map all of the currently circulating SARS-CoV-2 lineages with resistance towards LY-CoV555 and LY-CoV016, and document the specific mutations that confer resistance, ultimately suggesting that future monoclonal antibody cocktails should target a more diverse range of epitopes.

23 Feb 2021

GSK-3 inhibitors show promise in treating coronavirus infections

Researchers in the United States have suggested a new approach to treating infection with coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

23 Feb 2021

Glycan switch may explain why SARS-CoV-2 causes such variable symptoms

Researchers in Portugal have provided evidence that might explain why infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes mild or even asymptomatic illness in some individuals, but severe coronavirus disease 2019 (COVID-19) in others.

23 Feb 2021

Hormone known to prevent weight gain can help maintain healthy muscles in mice

A new study suggests that a hormone known to prevent weight gain and normalize metabolism can also help maintain healthy muscles in mice.

23 Feb 2021

Study identifies potential therapeutic target for treatment of Huntington's disease

Huntington's disease is caused by a mutation in the Huntingtin gene (HTT), which appears in adults and features motor, cognitive and psychiatric alterations.

23 Feb 2021

Researchers develop nanoceutical mask fabric that prevents SARS-CoV-2 transmission

Researchers at S N Bose National Centre for Basic Sciences in West Bengal found that a nanoceutical fabric, which is comfortable, washable, and anti-microbial, can prevent the transmission of SARS-CoV-2.

23 Feb 2021

Could laser-facilitated epicutaneous vaccination for SARS-CoV-2 be an alternative to intramuscular injection?

Scientists at the University of Salzburg and Pantec Biosolutions AG have developed a laser-facilitated epicutaneous immunization against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. The model has induced angiotensin-converting enzyme 2 (ACE2) blocking antibodies in mice.

23 Feb 2021

How effective has Israel’s SARS-CoV-2 testing and vaccination campaign been against the UK variant?

A recent study by researchers at Tel Aviv University describes the UK variant’s rise to dominance in Israel. It also assesses the efficacy of the testing and vaccination programs employed by the government.

23 Feb 2021

L452R mutation potentially favors adaptive evolution of SARS-CoV-2

A team of scientists from the United States recently investigated the mutational signatures in the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein.

23 Feb 2021

mRNA Therapeutics – Analytical and Bioanalytical Characterization

NewsMed interviews Anette Bak from AstraZeneca about her research on developments in mRNA therapeutics that she will present at Pittcon 2021.

From Pittcon 23 Feb 2021

Could rotavirus vaccine platforms aid in the immunization campaign against SARS-CoV-2?

The study began with the generation of recombinant (r)SA11 rotaviruses, into which segment 7 modified RNAs were introduced. These encoded sequences for the non-structural protein NSP3 and some parts of the viral spike.

23 Feb 2021

Scientists identify new compound that reverses ALS neuron damage

Northwestern University scientists have identified the first compound that eliminates the ongoing degeneration of upper motor neurons that become diseased and are a key contributor to ALS (amyotrophic lateral sclerosis), a swift and fatal neurodegenerative disease that paralyzes its victims.

23 Feb 2021

Protein C News and Research

Long-lasting B cells do not recognize emerging SARS-CoV-2 variants, shows study

COVID-19 may alter host proteins to cause autoimmunity

SARS-CoV-2 variants emerge during humoral immunity phase of acute COVID-19

Two potent SARS-CoV-2 neutralizing antibodies effective against B.1.351 and B.1.1.7 variants

New guidelines aim to help reduce blood pressure for chronic kidney disease patients

Research predicts which mammal species can spread SARS-CoV-2

Phase 1 clinical trial shows promising results for monoclonal antibodies against MERS coronavirus

Key mutation sites in the SARS-CoV-2 spike protein modulate antibody and ACE2 affinity

SARS-CoV-2 mutations allow escape from clinical monoclonal antibodies

GSK-3 inhibitors show promise in treating coronavirus infections

Glycan switch may explain why SARS-CoV-2 causes such variable symptoms

Hormone known to prevent weight gain can help maintain healthy muscles in mice

Study identifies potential therapeutic target for treatment of Huntington's disease

Researchers develop nanoceutical mask fabric that prevents SARS-CoV-2 transmission

Could laser-facilitated epicutaneous vaccination for SARS-CoV-2 be an alternative to intramuscular injection?

How effective has Israel’s SARS-CoV-2 testing and vaccination campaign been against the UK variant?

L452R mutation potentially favors adaptive evolution of SARS-CoV-2

mRNA Therapeutics – Analytical and Bioanalytical Characterization

Could rotavirus vaccine platforms aid in the immunization campaign against SARS-CoV-2?

Scientists identify new compound that reverses ALS neuron damage

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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