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Genetic mutations underlying treatment resistance in NSCLC more dynamic than previously thought

The genetic mutations underlying treatment resistance in non-small cell lung cancer (NSCLC) are more complex and dynamic than previously thought.

17 Mar 2017

Researchers use animal model to study brain abnormality in human TD patients

Thanatophoric dysplasia (TD) is an intractable disease designated by Ministry of Welfare, Health and Labor of Japan, causing severe abnormalities of bones and the brain.

17 Mar 2017

Study provides insights into how cancer cells can evade FGFR inhibitors

A new study by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.

2 Mar 2017

New clinical practice guideline addresses testing of molecular biomarkers in colorectal cancer patients

A new, evidenced-based clinical practice guideline on molecular biomarker testing for patients with colorectal cancer identifies opportunities for improving patient outcomes.

23 Feb 2017

Gene expression patterns could help predict treatment for breast cancer, research shows

A Michigan State University breast cancer researcher has shown that effective treatment options can be predicted based on the way certain breast cancer genes act or express themselves.

21 Feb 2017

Scientists engineer smallest CRISPR-Cas9 system to date

Scientists at the Center for Genome Engineering, within the Institute for Basic Science0, in collaboration with KIM Eunji and KIM Jeong Hun have engineered the smallest CRISPR-Cas9 to date, delivered it to the muscle cells and in the eyes of mice via adeno-associated viruses and used it to modify a gene causing blindness.

21 Feb 2017

Cancer cells adapt nerve cell mechanisms to fuel aggressive tumor growth and spread

How we think and fall in love are controlled by lightning-fast electrochemical signals across synapses, the dynamic spaces between nerve cells. Until now, nobody knew that cancer cells can repurpose tools of neuronal communication to fuel aggressive tumor growth and spread.

21 Feb 2017

Researchers explore effects of preeclampsia on risk of developing ROP in premature infants

Mary Elizabeth Hartnett, MD, and colleagues at the John A. Moran Center and Department of Pediatrics at the University of Utah and Children's Hospital of Wisconsin, were looking for a way to tease apart the effects of preeclampsia on the risk of developing retinopathy of prematurity (ROP), an eye disease found in premature infants. Their results, and the model they developed, were published February 14, 2017, in Scientific Reports.

15 Feb 2017

Scientists identify new biomarkers that could guide bowel cancer treatment

Colorectal carcinomas arise in different forms, so all treatments do not work for all patients. OncoTrack, a public-private consortium supported by the Innovative Medicines Initiative Joint Undertaking, has conducted one of Europe's largest collaborative academic-industry research projects to develop and assess novel approaches for identification of new markers for colon cancer.

13 Feb 2017

Study suggests new ways to treat neurological symptoms linked to tuberous sclerosis complex

Boston Children's Hospital researchers have uncovered a new molecular pathway that inhibits the myelination of neurons in the brains of patients with the rare genetic disorder tuberous sclerosis complex.

9 Feb 2017

Testing treatments for bone cancer may get easier with enhanced 3D-printed scaffolds

Testing treatments for bone cancer tumors may get easier with new enhancements to sophisticated support structures that mimic their biological environment, according to Rice University scientists.

9 Feb 2017

Increased growth factor protects retinal blood vessels in animal models with diabetes

Researchers from the Schepens Eye Research Institute of Massachusetts Eye and Ear have shown that a slight increase in transforming growth factor beta (TGF-β), which is present in preclinical animal models with diabetic eye disease, protects retinal blood vessels from damage that commonly occurs in the early stages of the disease.

2 Feb 2017

Mayo Clinic to test vaccine for providing lifelong immunity against precancerous breast lesions

Only about 35 percent of precancerous breast lesions morph into cancer if untreated, but physicians cannot identify which lesions are potentially dangerous.

2 Feb 2017

Medical experts issue new clinical guidelines for managing and treating short children

When is it appropriate to treat short children with growth hormone? The answer is not always clear-cut, as many parents and physicians have discovered over the past three decades.

25 Jan 2017

New biomarker helps better predict survival after surgical removal of colorectal metastases

Liver metastases are formed from cancer cells that have originated in other organs and migrated to the liver via the bloodstream. Colorectal cancer (cancer of the colon/rectum) can be successfully treated by surgical resection of the metastases in combination with chemotherapy.

23 Jan 2017

Study provides scientific insight into metastatic patterns of EGFR mutated NSCLCs

The discovery of several different subtypes of Non Small Cell Lung Cancer (NSCLC), the most frequent form of lung cancer, has been a major breakthrough in the fight against the leading cause of cancer-related death worldwide.

20 Jan 2017

Researchers uncover how stress hormone prevents digestive enzymes from damaging pancreas

UT Southwestern Medical Center researchers have uncovered the mechanism by which the stress hormone FGF21 keeps digestive enzymes from damaging the pancreas.

18 Jan 2017

New techniques and treatments show promise for eliminating retinopathy of prematurity

A mini-symposium published in the Journal of the American Association for Pediatric Ophthalmology and Strabismus provides important insights into new techniques and treatments that show promise for eliminating retinopathy of prematurity (ROP) throughout the world.

18 Jan 2017

Research offers new clues to prolong lifespan of the body's disease-fighting NK cells

A team of researchers from Australia and France have uncovered new insights into how to prolong the lifespan of the body's disease-fighting natural killer (NK) cells.

17 Jan 2017

Researchers move one step closer to regenerating heart wall using stem cells

A process using human stem cells can generate the cells that cover the external surface of a human heart -- epicardium cells -- according to a multidisciplinary team of researchers.

12 Jan 2017

Growth Factor News and Research

Genetic mutations underlying treatment resistance in NSCLC more dynamic than previously thought

Researchers use animal model to study brain abnormality in human TD patients

Study provides insights into how cancer cells can evade FGFR inhibitors

New clinical practice guideline addresses testing of molecular biomarkers in colorectal cancer patients

Gene expression patterns could help predict treatment for breast cancer, research shows

Scientists engineer smallest CRISPR-Cas9 system to date

Cancer cells adapt nerve cell mechanisms to fuel aggressive tumor growth and spread

Researchers explore effects of preeclampsia on risk of developing ROP in premature infants

Scientists identify new biomarkers that could guide bowel cancer treatment

Study suggests new ways to treat neurological symptoms linked to tuberous sclerosis complex

Testing treatments for bone cancer may get easier with enhanced 3D-printed scaffolds

Increased growth factor protects retinal blood vessels in animal models with diabetes

Mayo Clinic to test vaccine for providing lifelong immunity against precancerous breast lesions

Medical experts issue new clinical guidelines for managing and treating short children

New biomarker helps better predict survival after surgical removal of colorectal metastases

Study provides scientific insight into metastatic patterns of EGFR mutated NSCLCs

Researchers uncover how stress hormone prevents digestive enzymes from damaging pancreas

New techniques and treatments show promise for eliminating retinopathy of prematurity

Research offers new clues to prolong lifespan of the body's disease-fighting NK cells

Researchers move one step closer to regenerating heart wall using stem cells

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