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Novel investigational drug may help restore cardiac function after heart failure

Cimaglermin, a new experimental drug, may help restore cardiac function after heart failure, according to a first-in-man study published today in JACC: Basic to Translational Science.

27 Dec 2016

Researchers develop synthetic cardiac stem cells that offer therapeutic benefits

Researchers from North Carolina State University, the University of North Carolina at Chapel Hill and First Affiliated Hospital of Zhengzhou University have developed a synthetic version of a cardiac stem cell.

26 Dec 2016

Popular food supplement may be key in reversing detrimental effects of Familial Dysautonomia

A new Tel Aviv University study finds that a popular food supplement called phosphatidylserine may be instrumental in reversing the detrimental effects of Familial Dysautonomia (FD), a debilitating neurodegenerative disorder that affects approximately 1 in 31 Jewish people of Eastern European, or Ashkenazi, ancestry.

21 Dec 2016

Researchers explore kidney biomarkers to track lupus progression

Lupus, a chronic autoimmune disease, can wreak havoc on an affected individual's body through inflammation, pain and even damage of the skin, joints and organs.

16 Dec 2016

Overexpression of nerve growth factor drives gastric tumorigenesis in mice

Gastric tumors are started by specialized cells in the stomach that signal nerves to make more acetylcholine, according to a study in mice.

16 Dec 2016

Researchers pinpoint mechanism underlying astrocyte-mediated recovery of brain tissue after injury

A Kobe University research team has pinpointed the mechanism underlying astrocyte-mediated restoration of brain tissue after an injury. This could lead to new treatments that encourage regeneration by limiting damage to neurons incurred by reduced blood supply or trauma.

15 Dec 2016

Multifunctional RNA nanoparticles could overcome treatment resistance in breast cancer, study shows

Researchers at the University of Cincinnati College of Medicine have been able to generate multifunctional RNA nanoparticles that could overcome treatment resistance in breast cancer, potentially making existing treatments more effective in these patients.

15 Dec 2016

Anti-platelet drug may slow spread of colon and pancreatic cancer cells

Researchers from Oregon Health and Science University have found that aspirin may slow the spread of some types of colon and pancreatic cancer cells. The paper is published in the American Journal of Physiology—Cell Physiology.

15 Dec 2016

Brain metastasis persists in women with HER2-positive breast cancer despite new targeted therapies

While new targeted treatments developed across the past two decades have led to dramatic survival improvements for women with HER2-positive metastatic breast cancer, University of North Carolina Lineberger Comprehensive Cancer Center researchers and collaborators report that rates of breast cancer brain metastasis for women with this disease have not substantially declined.

7 Dec 2016

TSRI scientists reveal how vision-loss treatment may leave the eyes, kidneys vulnerable to cellular damage

A common class of drugs for vision loss may actually add to the problem in some patients, according to new research co-led by scientists at The Scripps Research Institute (TSRI).

7 Dec 2016

Combination of demineralized bone and gene therapy shows promise for treating pseudarthrosis

A team headed by Professor Albert Rizvanov, director of the Gene and Cell Technologies Open Lab, created a gene therapy drug that encodes growth factors for the stimulation of blood vessel and bone formation.

2 Dec 2016

Combination treatment may be valuable therapeutic option for HER2-negative metastatic breast cancer

Finding the ideal combination of targeted, hormonal and chemotherapeutic agents to treat HER2-negative metastatic breast cancer has been challenging researchers for decades.

1 Dec 2016

Cancer experts to discuss novel treatment strategies at ESMO Asia 2016 Congress

The ESMO Asia 2016 Congress announces its press programme today. The meeting brings together cancer experts in Singapore, from 16 to 19 December 2016.

23 Nov 2016

IQWiG finds colorectal cancer drug combination has added benefit only for some patients

The fixed combination of trifluridine/tipiracil has been approved since April 2016 for the treatment of metastatic colorectal cancer.

23 Nov 2016

Omega-3 fatty acids can stimulate activation of brown and beige adipose tissues, study finds

Omega-3 fatty acids are able to stimulate the activation of brown and beige adipose tissues, a discovery that would promote the development of new therapies for obesity and other metabolism diseases, according to a research study published in the journal Nature Communications under the supervision of Professor Francesc Villarroya, from the Department of Biochemistry and Molecular Biomedicine and the Biomedical Research Center Red-Fisiopatología de la Obesidad y Nutrición (CIBEROBN) of the Institute of Health Carlos III.

21 Nov 2016

New review highlights challenges of studying resistance to antiangiogenic treatment in preclinical models

New blood vessel growth, or angiogenesis, is critical for cancer to grow and spread throughout the body.

21 Nov 2016

Scientists identify naturally occurring molecule that plays protective role in ALS

Researchers at the Virginia Tech Carilion Research Institute have identified a naturally occurring molecule that has the potential for preserving sites of communication between nerves and muscles in amyotrophic lateral sclerosis (ALS) and over the course of aging -- as well as a molecule that interferes with this helpful process.

18 Nov 2016

Allergan, Amgen submit BLA for ABP 215 oncology biosimilar medicine to FDA

Amgen and Allergan plc. today announced the submission of a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for ABP 215, a biosimilar candidate to Avastin (bevacizumab).

16 Nov 2016

Experimental drug outperforms standard first-line therapy for advanced kidney cancer patients

An experimental kidney cancer drug outperformed the standard first-line therapy for patients with metastatic disease who are considered at risk for poorer than average outcomes, according to results of a randomized phase II clinical trial by researchers at Dana-Farber Cancer Institute.

15 Nov 2016

Promethera presents new preclinical NASH-Fibrosis data from HepaStem program at AASLD meeting

Promethera Biosciences SA, a world-leading cell therapy and regenerative medicine company targeting liver diseases, today announced the presentation of new preclinical NASH-Fibrosis data from its proprietary HepaStem program, demonstrating a beneficial effect of HepaStem in a nonalcoholic steatohepatitis (NASH) mouse model and confirming Hepastem’s unique and multifaceted mode of action.

15 Nov 2016

Growth Factor News and Research

Novel investigational drug may help restore cardiac function after heart failure

Researchers develop synthetic cardiac stem cells that offer therapeutic benefits

Popular food supplement may be key in reversing detrimental effects of Familial Dysautonomia

Researchers explore kidney biomarkers to track lupus progression

Overexpression of nerve growth factor drives gastric tumorigenesis in mice

Researchers pinpoint mechanism underlying astrocyte-mediated recovery of brain tissue after injury

Multifunctional RNA nanoparticles could overcome treatment resistance in breast cancer, study shows

Anti-platelet drug may slow spread of colon and pancreatic cancer cells

Brain metastasis persists in women with HER2-positive breast cancer despite new targeted therapies

TSRI scientists reveal how vision-loss treatment may leave the eyes, kidneys vulnerable to cellular damage

Combination of demineralized bone and gene therapy shows promise for treating pseudarthrosis

Combination treatment may be valuable therapeutic option for HER2-negative metastatic breast cancer

Cancer experts to discuss novel treatment strategies at ESMO Asia 2016 Congress

IQWiG finds colorectal cancer drug combination has added benefit only for some patients

Omega-3 fatty acids can stimulate activation of brown and beige adipose tissues, study finds

New review highlights challenges of studying resistance to antiangiogenic treatment in preclinical models

Scientists identify naturally occurring molecule that plays protective role in ALS

Allergan, Amgen submit BLA for ABP 215 oncology biosimilar medicine to FDA

Experimental drug outperforms standard first-line therapy for advanced kidney cancer patients

Promethera presents new preclinical NASH-Fibrosis data from HepaStem program at AASLD meeting

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