Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Biomarker may help identify prostate cancer patients at increased risk of metastasis

For about 90 percent of men with prostate cancer, the cancer remains localized to the primary site, resulting in a five-year survival rate of almost 100 percent.

9 May 2019

Small molecule drug may help overcome ibrutinib resistance in mantle cell lymphona

A study at The University of Texas MD Anderson Cancer Center demonstrated how a small molecule drug discovered at the institution may help overcome resistance to treatment with ibrutinib in patients with mantle cell lymphoma.

9 May 2019

Inhibition of ribosome biogenesis as new treatment strategy for advanced cancers

Nearly ninety per cent of all cancer patient deaths are due to metastasis. A study from Uppsala University shows that a process that allows the cells to metastasize is aided by the synthesis of new ribosomes, the cell components in which proteins are produced.

8 May 2019

Researchers unravel the biology of how obesity promotes triple-negative breast cancer

Smoking has long been the biggest cause of cancer in the United States, but obesity, now the second leading cause, has been gaining ground.

7 May 2019

Researchers develop a new approach to targeting tumors and metastases

The spread of malignant cells from an original tumor to other parts of the body, known as metastasis, is the main cause of cancer deaths worldwide.

7 May 2019

Form drives function in cancer proliferation, UTSW study finds

A new study finds that the protein responsible for the crawling movements of cells also drives the ability of cancer cells to grow when under stress.

6 May 2019

Scientists discover biological barrier that keeps cancer at bay

Activins are proteins involved in a number of important biological functions, including the regulation of the menstrual cycle, cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function.

6 May 2019

Researchers identify four hallmarks of cancer metastasis

Researchers at the University of Alabama at Birmingham and the University of Kansas Cancer Center have identified four hallmarks of cancer metastasis -- when cancer has spread to different parts of the body from where it started. Metastasis is believed to be the cause of up to 90 percent of cancer deaths.

3 May 2019

Elderly survivors of breast, lung, and skin cancers face risk of brain metastasis later in life

Elderly survivors of breast cancer, lung cancer, and melanoma face risk of brain metastasis later in life, and may require extra surveillance in the years following initial cancer treatment.

3 May 2019

Updated ASTRO/AUA Guideline on adjuvant and salvage radiotherapy after prostatectomy

The American Society for Radiation Oncology and the American Urological Association today announced updates to their joint clinical guideline on adjuvant and salvage radiotherapy after prostatectomy in patients with and without evidence of prostate cancer recurrence to include new published research related to adjuvant radiotherapy.

1 May 2019

Multigene test helps doctors to make effective treatment decisions for breast cancer patients

A breast cancer test has been found that helps doctors make treatment decisions for some breast cancer patients, following research carried out at Queen Mary University of London and funded by Cancer Research UK.

30 Apr 2019

Prior radioprotection via EGLN inhibitor improves survival in mouse model of pancreatic cancer

Administration of the EGLN inhibitor FG-4592 prior to ablative radiotherapy provided protection against fatal gastrointestinal bleeding and improved survival in a mouse model of unresectable pancreatic cancer.

30 Apr 2019

Researcher studies two protein families known to play role in cancer metastasis

In a paper published in the Journal of Biological Chemistry, Dr. özdemir has studied two protein families named Rho GTPases and IQGAPs, which are known to play an important role in cancer metastasis.

30 Apr 2019

Blocking BRAF ubiquitination may be an effective treatment approach in melanoma

The protein BRAF is a key player in the development of many different types of cancer, including melanoma.

24 Apr 2019

Cancer drugs reprogram genes in breast tumors to prevent endocrine resistance, finds study

Treating breast tumors with two cancer drugs simultaneously may prevent endocrine resistance by attacking the disease along two separate gene pathways, scientists at the University of Illinois found in a new study.

24 Apr 2019

Potential of liquid biopsy in cancer biomarker detection and prenatal testing

The promise and challenges of liquid biopsy, an emerging, noninvasive method for targeted disease diagnosis and detection of cancer biomarkers to enable improved and personalized therapy, is the focus of a new special issue of Genetic Testing and Molecular Biomarkers, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

22 Apr 2019

Deep-learning model better predicts survival outcomes for lung cancer

A deep-learning model developed using serial image scans of tumors from patients with non-small cell lung cancer (NSCLC) predicted treatment response and survival outcomes better than standard clinical parameters.

22 Apr 2019

HPV-negative cervical cancers are more aggressive with worse prognosis

Cervical cancer negative for the human papilloma virus (HPV) is rare but more aggressive: it is more frequently diagnosed at advanced stages, with more metastasis and reduced survival.

17 Apr 2019

Restoring function of 'misregulated' cancer-fighting genes

Working with human colon cancer cells and mice, researchers led by experts at the Johns Hopkins Kimmel Cancer Center say they have successfully blocked the activity of portions of a protein known as UHRF1 and restored the function of hundreds of cancer-fighting genes that became "misregulated" by the disease.

15 Apr 2019

New liquid biopsy technique used to assess melanoma progression

When the surgeon surgically removes a melanoma, some patients are said to be 'cancer-free' and they do not get additional treatment. However, should the fluid obtained in the drainage implanted after surgery be tested using the liquid biopsy technique rather than be disposed of as medical waste, the test might predict the high or low risk of cancer recurrence.

11 Apr 2019

Metastasis News and Research

Further Reading

Biomarker may help identify prostate cancer patients at increased risk of metastasis

Small molecule drug may help overcome ibrutinib resistance in mantle cell lymphona

Inhibition of ribosome biogenesis as new treatment strategy for advanced cancers

Researchers unravel the biology of how obesity promotes triple-negative breast cancer

Researchers develop a new approach to targeting tumors and metastases

Form drives function in cancer proliferation, UTSW study finds

Scientists discover biological barrier that keeps cancer at bay

Researchers identify four hallmarks of cancer metastasis

Elderly survivors of breast, lung, and skin cancers face risk of brain metastasis later in life

Updated ASTRO/AUA Guideline on adjuvant and salvage radiotherapy after prostatectomy

Multigene test helps doctors to make effective treatment decisions for breast cancer patients

Prior radioprotection via EGLN inhibitor improves survival in mouse model of pancreatic cancer

Researcher studies two protein families known to play role in cancer metastasis

Blocking BRAF ubiquitination may be an effective treatment approach in melanoma

Cancer drugs reprogram genes in breast tumors to prevent endocrine resistance, finds study

Potential of liquid biopsy in cancer biomarker detection and prenatal testing

Deep-learning model better predicts survival outcomes for lung cancer

HPV-negative cervical cancers are more aggressive with worse prognosis

Restoring function of 'misregulated' cancer-fighting genes

New liquid biopsy technique used to assess melanoma progression

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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