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Cryo-electron microscopy offers an unprecedented view of gene transcription

The enzyme RNA polymerase (RNAP) carries out transcription, copying DNA into RNA. It's the first step in gene expression, and a process fundamental to all life.

30 Apr 2026

Study shows eIF4G2 gene maintains adult intestinal stem cell identity

Years before he conducted the research that would earn him a Nobel Prize in Physiology and Medicine, Shinya Yamanaka, MD, PhD, was a postdoctoral scientist at Gladstone Institutes, studying genes.

30 Apr 2026

Study reveals new immune mechanism behind mevalonate kinase deficiency

Researchers at the Garvan Institute of Medical Research have uncovered a critical mechanism driving inflammation in mevalonate kinase deficiency (MKD), a rare but devastating autoinflammatory disorder.

30 Apr 2026

T1GRS model enhances prediction of genetic risk for Type 1 diabetes

In people with Type 1 diabetes (T1D), the immune system shuts down the body's ability to make the hormone insulin, responsible for regulating blood sugar and providing cells with glucose to produce energy.

30 Apr 2026

Pathogens drive inflammation by reprogramming host cell metabolic processes

An intestinal pathogen reshapes the gut environment to fuel its own colonization and cause diseases, a multi-institutional team including researchers at Vanderbilt Health has discovered.

30 Apr 2026

Sickness behavior may be a coordinated whole organism immune strategy

Symptoms such as fatigue, loss of appetite, altered sleep, and social withdrawal are often treated as inconvenient side effects of infection.

30 Apr 2026

Dangerous water bead ingestions increase among young children

A new study reveals that ingestions of water beads by young children have surged in recent years. Researchers at the Center for Injury Research and Policy of the Abigail Wexner Research Institute at Nationwide Children's Hospital and the Central Ohio Poison Center analyzed calls to U.S. poison centers and found an alarming 6,532% increase in the rate of reported water bead ingestions among children younger than 6 years from 2019 to 2023, followed by a 24% decrease from 2023 to 2024.

30 Apr 2026

Liquid biopsy predicts immune response in high-risk breast cancer patients

Immunotherapy has become a standard of care in treating high-risk, early-stage breast cancers, yet it has had limited success in shrinking tumors.

30 Apr 2026

Degeneration in two brain regions causes severe narcolepsy symptoms

For nearly 25 years, scientists believed they knew what caused the most severe form of narcolepsy. A new UCLA Health study now suggests they were only half correct.

30 Apr 2026

Scientists discover a potential new way to slow ALS disease progression

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes the progressive loss of motor neurons, which in most cases leads to respiratory failure within three to five years after diagnosis.

30 Apr 2026

Inflammation from leaking mitochondria drives aggressive pancreatic cancer growth

Scientists at The Wistar Institute and clinical researchers from ChristianaCare's Helen F. Graham Cancer Center & Research Institute have discovered a vulnerability in pancreatic cancer that could be targeted as a potential therapy.

30 Apr 2026

UCLA researchers build programmable artificial organelles using RNA

Just as the human body relies on organs such as the heart or liver for essential functions, cells depend on their own tiny organs, or organelles, to carry out vital tasks, including transporting nutrients, removing waste and regulating genetic activity.

30 Apr 2026

Glucose acts as a metabolic signal for myelin development

Researchers at the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have uncovered a surprising link between low brain sugar levels and the development of myelin - the protective coating that allows nerve cells to communicate rapidly and efficiently.

30 Apr 2026

Maternal screening could help prevent deadly forms of leukemia

A deadly form of leukemia may be stopped before it ever develops by introducing targeted maternal screening in the United States, according to new research.

30 Apr 2026

Antibiotic minocycline shows potential for treating panic disorder symptoms

A study supported by FAPESP shows that small doses of the antibiotic minocycline may help treat panic disorder.

30 Apr 2026

From killers to strategists: CAR T cells enter their multifunctional era

A review of 1,801 registered CAR T clinical trials shows that multifunctional designs now account for 533 trials and 33% of new CAR T products submitted for clinical testing in 2025. The field is shifting toward multitargeted, safety-controlled, cytokine-secreting, and checkpoint-modulating CAR T cells, but manufacturing, regulation, and limited clinical outcome data remain key barriers.

30 Apr 2026

Single-cell sequencing reveals why some CAR-T therapies succeed while others fail

Single-cell RNA sequencing is giving researchers a clearer view of why some CAR-T cells persist, expand, kill tumors effectively, or become exhausted. The review synthesizes 44 clinical scRNA-seq studies involving 500 patients and highlights how exhaustion, memory, cytotoxicity, clonal diversity, and metabolism may shape CAR-T responses.

30 Apr 2026

Metabolic rewiring could help CAR-T cells fight solid tumors

This review explains how glucose scarcity, lipid disruption, amino acid deprivation, and toxic metabolites weaken CAR-T cells inside solid tumors. It highlights metabolic reprogramming as a promising strategy to improve CAR-T cell persistence, adaptability, and anti-tumor function.

29 Apr 2026

How multi-omics is changing what scientists can see in the human immune system

Human systems immunology is using multi-omics, single-cell tools, spatial technologies, and AI to decode immune responses across real-world human cohorts. The review highlights major opportunities for biomarker discovery and precision medicine, while stressing the need for rigorous study design, validation, and careful interpretation.

29 Apr 2026

New imaging agent shows promise for non-invasive endometriosis diagnosis

The Nuffield Department of Women's & Reproductive Health at the University of Oxford, together with Serac Healthcare Limited announces the publication of Phase 2 data in The Lancet Obstetrics and Gynaecology.

29 Apr 2026