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A novel approach to understanding protein compartmentalization

In physics, a system composed of two substances can be modeled in accordance with classical mixture theory, which considers the fraction corresponding to each constituent and the interactions among constituents. Examples include the coexistence of high- and low-density phases in supercooled water and the coexistence of metal puddles in an insulating matrix in the Mott metal-insulator transition.

14 Oct 2024

New insights on protein degraders open doors to treatment for 'undruggable' diseases

Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called 'protein degraders' which can be deployed to combat what have previously been regarded as 'undruggable' diseases, including cancers and neurodegenerative diseases.

12 Oct 2024

New insights into stem cell control in plant meristems

Researchers from the University of Freiburg have identified the HAN molecule as an important regulator that controls plant growth in conjunction with WOX5.

12 Oct 2024

Innovative tissue expansion technique transforms conventional microscopy capabilities

A classical way to image nanoscale structures in cells is with high-powered, expensive super-resolution microscopes. As an alternative, MIT researchers have developed a way to expand tissue before imaging it - a technique that allows them to achieve nanoscale resolution with a conventional light microscope.

12 Oct 2024

Breakthrough in mirror molecule synthesis opens doors for drug discovery

A University of Texas at Dallas chemist and his colleagues have developed a new chemical reaction that will allow researchers to synthesize selectively the left-handed or right-handed versions of "mirror molecules" found in nature and assess them for potential use against cancer, infection, depression, inflammation and a host of other conditions.

10 Oct 2024

Decoding Cannabis: Differentiating Hemp and Marijuana

In this interview conducted at Pittcon 2024 in San Diego, Rabi Musah delves into her innovative use of DART-HRMS and chemometric analysis to differentiate between hemp and marijuana varieties of Cannabis sativa, exploring the forensic and legal implications of these findings.

From Pittcon 10 Oct 2024

Novel antibody shows promise for pain relief in peripheral nerves

Cell surface proteins play a crucial role in cell communication and in sensing changes in the extracellular environment.

9 Oct 2024

New research offers hope for treating metabolic dysfunction-associated liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) — previously known as "non-alcoholic fatty liver disease" — affects about 25% of the global population.

9 Oct 2024

The new science behind the health benefits of caffeine

A study reveals caffeine's potential to enhance heart health by improving endothelial function in systemic lupus erythematosus patients through EPC survival.

9 Oct 2024

Tiny molecule offers hope in reducing opioid side effects

Opioid drugs are highly effective at relieving pain but come with severe drawbacks. Their side effects range from dizziness to potentially fatal respiratory depression.

9 Oct 2024

Novel compounds show promise in fighting COVID-19

New research from The Wistar Institute's Salvino lab - led by professor Joseph Salvino, Ph.D. - has identified a novel series of SARS-CoV-2 Mpro inhibitors that may lead to potential new COVID-19 treatments that, according to preclinical testing, effectively inhibits COVID-19 and synergizes with existing anti-COVID therapies.

8 Oct 2024

Breakthrough study reveals Entropic Pulling mechanism of Hsp70 chaperones

Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer.

8 Oct 2024

Study identifies RNA molecule crucial for skin wound healing

A new study from Karolinska Institutet in Sweden and the Chinese Academy of Medical Sciences has identified an RNA molecule that is important for skin wound healing.

8 Oct 2024

Study reveals how morphogens and cell adhesion create sharp tissue boundaries

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, demonstrate how morphogens combined with cell adhesion can generate tissue domains with a sharp boundary in an in vitro model system.

8 Oct 2024

New insights into how DAPK3 regulates the migration of triple-negative breast cancer cells

Triple-negative breast cancer (TNBC) is the subtype of breast cancer that is the hardest to treat. TNBC patients account for more than 20,000 cases of this condition annually in the U.S. alone.

8 Oct 2024

New triple-targeting pharmacological tool developed for cancer treatment

A study led by researchers of the Institute of Biomedicine of the University of Barcelona (IBUB) has developed a new pharmacological tool capable of simultaneously administering three oligonucleotide-based drugs, each acting against a different therapeutic target within the cell.

8 Oct 2024

New insights on 5-fluorouracil's mechanism in different cancers

Study reveals the drug, 5-fluorouracil, acts differently in different types of cancer — a finding that could help researchers design better drug combinations.

7 Oct 2024

New deep-learning framework identifies non-addictive pain relief options

An estimated one in five Americans live with chronic pain and current treatment options leave much to be desired.

7 Oct 2024

How carnitine transporters boost reproductive health

Research uncovers the critical role of carnitine transporters in maintaining fertility by regulating energy metabolism and protecting reproductive cells from oxidative stress. It suggests new pathways for treating infertility through carnitine supplementation and targeted therapies.

6 Oct 2024

Study identifies ophthalmic acid as an alternative to dopamine in motor control

A research team from the University of California, Irvine is the first to reveal that a molecule in the brain – ophthalmic acid – unexpectedly acts like a neurotransmitter similar to dopamine in regulating motor function, offering a new therapeutic target for Parkinson's and other movement diseases.

4 Oct 2024