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Pembrolizumab in combination with chemotherapy improves progression free survival for women with advanced or recurrent endometrial cancer

NRG Oncology Phase III clinical trial, NRG-GY018, evaluating pembrolizumab in combination with standard of care chemotherapy (carboplatin and paclitaxel) met its primary endpoint of progression free survival (PFS) for the treatment of patients with stage III-IV or recurrent endometrial carcinoma, regardless of mismatch repair status.

3 Feb 2023

Molnupiravir-related mutational signatures among COVID-19 patients

Researchers explore a mutational signature related to molnupiravir in SARS-CoV-2 sequencing datasets.

3 Feb 2023

BCG vaccine does not protect elderly with co-morbidities against COVID-19

The tuberculosis vaccine (or BCG vaccine) does not protect elderly with co-morbidities against disease symptoms caused by a coronavirus infection.

2 Feb 2023

Trial shows the benefit of using a celery seed-derived medication after clot treatment in stroke patients

People who had an ischemic (clot-caused) stroke and were treated with a clot-busting medication and/or mechanical clot removal and also received butylphthalide, a medication initially compounded from celery seed, experienced milder neurological symptoms with better functioning at three months after the stroke, compared to stroke patients who had their clots treated but received a placebo medication, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2023.

2 Feb 2023

A more nuanced approach is needed when prescribing antidepressants for pain, researchers say

Some antidepressant drugs are effective for some pain conditions, but most are either ineffective or the evidence is inconclusive, despite being used for a range of pain conditions, finds an overview of the latest evidence published by The BMJ today.

1 Feb 2023

Adding veliparib to chemotherapy can extend progression-free survival in patients with “BRCA-like” breast cancer

Results from the SWOG S1416 clinical trial show that adding veliparib to chemotherapy can significantly extend progression-free survival (PFS) times in patients with triple-negative breast cancer (TNBC) that has a "BRCA-like" phenotype.

31 Jan 2023

Patients with myelofibrosis show improvement in disease-related symptoms when treated with momelotinib

Patients with myelofibrosis had clinically significant improvement in disease-related symptoms, including anemia and spleen enlargement, when treated with the targeted therapy momelotinib, according to results from the international Phase III MOMENTUM trial led by researchers at The University of Texas MD Anderson Cancer Center.

29 Jan 2023

Nitrate boost causes an increase in muscle force during exercise

A new study has found that consuming dietary nitrate – the active molecule in beetroot juice – significantly increased muscle force while exercising.

23 Jan 2023

Scientists reveal why common anti-depressants cause emotional ‘blunting’ in users

Scientists have worked out why common anti-depressants cause around a half of users to feel emotionally 'blunted'.

23 Jan 2023

Long-term, COVID-19-related smell loss could be treated using injections of platelet-rich plasma

Early in the pandemic, when people with COVID-19 began reporting that they lost their sense of smell, Zara Patel, MD, figured as much. A professor of otolaryngology at Stanford Medicine, Patel has, for years, studied loss of smell as a symptom of viral infections.

19 Jan 2023

Overweight people have a different vitamin D metabolism

A new study in JAMA Network Open aimed to determine whether BMI is capable of modifying vitamin D metabolism as well as response to supplementation.

18 Jan 2023

Investigational vaccine regimen safe but did not provide protection against HIV acquisition

An investigational HIV vaccine regimen tested among men who have sex with men (MSM) and transgender people was safe but did not provide protection against HIV acquisition, an independent data and safety monitoring board (DSMB) has determined.

18 Jan 2023

The efficacy of low-dose fluvoxamine compared with placebo for treating mild to moderate COVID-19 in the US

Researchers evaluated the efficacy of low-dosage fluvoxamine (50 mg two times a day) over 10 days in the management of mild and moderate-SARS-CoV-2 infections in the US.

18 Jan 2023

Probiotic diminishes S. aureus bacterial colonization, Phase 2 trial shows

A promising approach to control Staphylococcus aureus bacterial colonization in people - using a probiotic instead of antibiotics - was safe and highly effective in a Phase 2 clinical trial.

17 Jan 2023

Simple nasal spray effective at easing sleep-disordered breathing in children

A simple nasal spray significantly reduced snoring and breathing difficulties in children and halved the number needing to have their tonsils removed, according to a new study.

17 Jan 2023

Acupuncture could be a safe and feasible management option for IBS-D

Researchers preliminarily evaluated the practicality of utilizing the United States (US) Food and Drug Administration (FDA)-advocated endpoints to assess the effectiveness of acupuncture in IBS-D (irritable bowel syndrome with diarrhea) management.

5 Jan 2023

Study demonstrates safety and efficacy of a three-dose whole-parasite vaccine against malaria

A three-dose regimen of a whole-parasite vaccine against malaria – called Plasmodium falciparum sporozoite (PfSPZ) vaccine – demonstrated safety and efficacy when tested in adults living in Burkina Faso, West Africa, which has endemic malaria.

4 Jan 2023

How could probiotics be used in the management of gingivitis and periodontitis?

New research explores how probiotic-based therapy in conjunction with established treatment regimens can be an effective approach for combating gingivitis and periodontitis.

28 Dec 2022

Molnupiravir does not reduce hospitalization or deaths in vaccinated adults with COVID-19, but improves recovery

Molnupiravir (taken as an 800mg dose twice daily for five days) does not reduce hospital admissions or deaths in vaccinated adults with COVID-19 infection who are at higher risk of mortality, according to the results of a randomised controlled trial, published in The Lancet journal.

23 Dec 2022

Clinical trials demonstrate safety and efficacy of Ebola Zaire vaccines

Two vaccines against the Zaire strain of Ebola virus are immunogenic and safe in both adults and children, according to initial results from two phase II clinical trials published in the New England Journal of Medicine.

21 Dec 2022

Placebo News and Research

Pembrolizumab in combination with chemotherapy improves progression free survival for women with advanced or recurrent endometrial cancer

Molnupiravir-related mutational signatures among COVID-19 patients

BCG vaccine does not protect elderly with co-morbidities against COVID-19

Trial shows the benefit of using a celery seed-derived medication after clot treatment in stroke patients

A more nuanced approach is needed when prescribing antidepressants for pain, researchers say

Adding veliparib to chemotherapy can extend progression-free survival in patients with “BRCA-like” breast cancer

Patients with myelofibrosis show improvement in disease-related symptoms when treated with momelotinib

Nitrate boost causes an increase in muscle force during exercise

Scientists reveal why common anti-depressants cause emotional ‘blunting’ in users

Long-term, COVID-19-related smell loss could be treated using injections of platelet-rich plasma

Overweight people have a different vitamin D metabolism

Investigational vaccine regimen safe but did not provide protection against HIV acquisition

The efficacy of low-dose fluvoxamine compared with placebo for treating mild to moderate COVID-19 in the US

Probiotic diminishes S. aureus bacterial colonization, Phase 2 trial shows

Simple nasal spray effective at easing sleep-disordered breathing in children

Acupuncture could be a safe and feasible management option for IBS-D

Study demonstrates safety and efficacy of a three-dose whole-parasite vaccine against malaria

How could probiotics be used in the management of gingivitis and periodontitis?

Molnupiravir does not reduce hospitalization or deaths in vaccinated adults with COVID-19, but improves recovery

Clinical trials demonstrate safety and efficacy of Ebola Zaire vaccines

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