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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Environmental factors significantly impact gene expression through epigenetic modifications

Epigenetics, the study of changes in gene function that do not involve alterations to the DNA sequence, plays a pivotal role in understanding the complex interplay between genetics and the environment. The review article "Epigenetics and Environmental Health" provides an in-depth analysis of how epigenetic modifications can influence the onset and progression of various diseases, particularly cancer and cardiovascular diseases.

8 Oct 2024

Overcoming CRISPR's side effects for therapeutic applications

CRISPR is a revolutionary tool that allows scientists to precisely modify the genome and gene expression of cells in any organism. It's a reagent - a substance that facilitates a reaction - that combines an enzyme with a programmable RNA capable of locating specific genetic sequences. Once guided to the correct spot, the enzyme acts like a pair of scissors, cutting, replacing, or deleting sequences of DNA.

7 Oct 2024

Doxycycline increases antimicrobial resistance in the gut without disrupting microbiome diversity

Doxycycline post-exposure prophylaxis increases tetracycline resistance genes in the gut, without significantly affecting microbiome diversity in men who have sex with men and transgender women.

7 Oct 2024

Researchers uncover how senescent cells can both harm and heal in liver disease

Researchers developed novel genetic tools to trace, ablate, and manipulate p16^Ink4a+^ senescent cells, revealing their distinct roles in liver fibrosis and repair. Senescent macrophages promote fibrosis, while endothelial cells aid in tissue recovery.

7 Oct 2024

New insights on 5-fluorouracil's mechanism in different cancers

Study reveals the drug, 5-fluorouracil, acts differently in different types of cancer — a finding that could help researchers design better drug combinations.

7 Oct 2024

When CDK12/13 stalls, healthy prostate cells take a malignant turn

CDK12 is established as a tumor suppressor in prostate cancer, with its loss driving aggressive disease and creating vulnerabilities for targeted therapies.

7 Oct 2024

Researchers identify key mechanism behind atherosclerosis in Hutchinson-Gilford progeria syndrome

A team of researchers from the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), the Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), and the Instituto de Ciencias de Materiales de Madrid (ICMM-CSIC) has made a significant breakthrough in understanding the underlying causes of cardiovascular disease in patients with Hutchinson-Gilford progeria syndrome (HGPS), an ultra-rare genetic disorder that accelerates the aging process.

7 Oct 2024

Pasteurization effectively reduces H5N1 virus in milk but further testing is essential

Research explores the resilience of the H5N1 influenza virus in milk under pasteurization conditions, showing effective viral inactivation at standard temperatures but highlighting the need for further real-world testing.

6 Oct 2024

Researchers reveal mechanisms of how CDK12 alterations drive prostate cancer development

When researchers at the University of Michigan Rogel Cancer Center first identified a new subtype of aggressive prostate cancer, they knew they needed to understand how this genetic alteration was driving cancer and how to target it with treatment.

4 Oct 2024

New insights into the role of gamma-delta T cells across 33 cancer types revealed

A new study published in Cell Press reveals critical insights into the role of gamma-delta T cells across 33 cancer types, shedding light on their potential as clinical biomarkers and therapeutic targets in cancer treatment.

4 Oct 2024

Identical twins study uncovers insights into multiple sclerosis mechanisms

Multiple sclerosis (MS) is a chronic inflammatory disease in which the immune system attacks the central nervous system.

4 Oct 2024

Study highlights benefits and risks of doxy-PEP for STI prevention

Taking a dose of the oral antibiotic doxycycline after a high-risk sexual encounter has dramatically reduced the incidence of sexually transmitted infections (STIs) in places where the strategy is being tried.

4 Oct 2024

Houston Methodist researchers join national consortium to develop herpesvirus vaccine

Houston Methodist researchers will be part of a national consortium funded by an up to $49 million award from the U.S. Government's Advanced Research Projects Agency for Health (ARPA-H) to develop a vaccine against two of the most common and destructive strains of herpesviruses that latently infect a majority of Americans and can lead to acute infections, multiple forms of cancer, autoimmune disease and birth defects.

3 Oct 2024

International experts to gather for ALS symposium in Chicago

The 2024 Les Turner Symposium on ALS will be held on Monday, Nov. 4 in Chicago. Hosted by the Les Turner ALS Foundation and the Les Turner ALS Center at Northwestern Medicine, this event will assemble internationally-renowned ALS researchers, clinicians, advocates, and people living with ALS to discuss the latest research and perspectives on the disease.

3 Oct 2024

Innovative blood test for lung cancer offers faster and more sensitive diagnosis

A new way of diagnosing lung cancer with a blood draw is 10 times faster and 14 times more sensitive than earlier methods, according to University of Michigan researchers.

3 Oct 2024

Key RNA pathway controlling DNA packaging and cancer progression

Inside every cell, inside every nucleus, your continued existence depends on an incredibly complicated dance. Proteins are constantly wrapping and unwrapping DNA, and even minor missteps can lead to cancer.

3 Oct 2024

The impact of KRAS mutations on pancreatic cancer progression and survival

A common mutation in the KRAS gene is associated with improved overall survival in pancreatic ductal adenocarcinoma (PDAC) compared with other variants, in part because the mutation appears to lead to less invasiveness and weaker biological activity, according to a multicenter study conducted at Weill Cornell Medicine, NewYork-Presbyterian, Memorial Sloan Kettering Cancer Center, and other institutions.

3 Oct 2024

New insights into the link between respiratory infections and chronic lung diseases

A 3D reconstruction of a mouse lung four days after infection with fluorescent Sendai virus reveals widespread virus presence (red) and active replication (green).

3 Oct 2024

Frailty linked to diminished quality of life in cancer and transplant survivors

A new research paper was published on the in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 18 on September 26, 2024, entitled, "Frailty and pre-frailty associated with long-term diminished physical performance and quality of life in breast cancer and hematopoietic cell transplant survivors."

2 Oct 2024

Scientists uncover two Crohn’s disease subtypes using lab-grown intestines, offering hope for personalized therapies

Researchers used stem-cell derived organoids from Crohn's disease patients to identify two molecular subtypes, paving the way for personalized treatments targeting specific disease characteristics.

2 Oct 2024

RNA News and Research

Further Reading

Environmental factors significantly impact gene expression through epigenetic modifications

Overcoming CRISPR's side effects for therapeutic applications

Doxycycline increases antimicrobial resistance in the gut without disrupting microbiome diversity

Researchers uncover how senescent cells can both harm and heal in liver disease

New insights on 5-fluorouracil's mechanism in different cancers

When CDK12/13 stalls, healthy prostate cells take a malignant turn

Researchers identify key mechanism behind atherosclerosis in Hutchinson-Gilford progeria syndrome

Pasteurization effectively reduces H5N1 virus in milk but further testing is essential

Researchers reveal mechanisms of how CDK12 alterations drive prostate cancer development

New insights into the role of gamma-delta T cells across 33 cancer types revealed

Identical twins study uncovers insights into multiple sclerosis mechanisms

Study highlights benefits and risks of doxy-PEP for STI prevention

Houston Methodist researchers join national consortium to develop herpesvirus vaccine

International experts to gather for ALS symposium in Chicago

Innovative blood test for lung cancer offers faster and more sensitive diagnosis

Key RNA pathway controlling DNA packaging and cancer progression

The impact of KRAS mutations on pancreatic cancer progression and survival

New insights into the link between respiratory infections and chronic lung diseases

Frailty linked to diminished quality of life in cancer and transplant survivors

Scientists uncover two Crohn’s disease subtypes using lab-grown intestines, offering hope for personalized therapies

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