Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

New source of stem cells could help treat people with Alagille syndrome

Researchers from Sanford Burnham Prebys have discovered a new source of stem cells just outside the liver that could help treat people living with Alagille syndrome, a rare, incurable genetic disorder in which the bile ducts of the liver are absent, leading to severe liver damage and death.

12 Oct 2021

Novel proteomics approach predicts severe COVID-19 outcomes

Researchers in the United States, Canada, and the UK have developed a potential new approach to predicting severe and critical outcomes among patients with coronavirus disease 2019 (COVID-19).

6 Oct 2021

Study finds increased risk for SARS-CoV-2 breakthrough infections in people with substance use disorders

An analysis of electronic health records of nearly 580,000 fully vaccinated people in the United States found that the risk of SARS-CoV-2 breakthrough infection among vaccinated patients with substance use disorders was low overall, but higher than the risk among vaccinated people without substance use disorders.

6 Oct 2021

Researchers publish new datasets to better train machine learning models for drug discovery

Polymorphs are molecules that have different molecular packing arrangements despite identical chemical compositions.

2 Oct 2021

Study investigates long-COVID symptoms in people recovering from COVID-19 infection

This new study from the University of Oxford and the National Institute for Health Research (NIHR) Oxford Health Biomedical Research Centre (BRC) investigated long-COVID in over 270,000 people recovering from COVID-19 infection, using data from the US-based TriNetX electronic health record network.

30 Sep 2021

Researchers discover working mechanism of potential drug targets for COVID-19

A team of international researchers, including McGill Professor Stéphane Laporte, have discovered the working mechanism of potential drug targets for various diseases such as cancer, rheumatoid arthritis, and even COVID-19.

28 Sep 2021

COVID Moonshot receives key funding to accelerate drug discovery efforts

The COVID Moonshot, a non-profit, open-science consortium of scientists from around the world dedicated to the discovery of globally affordable and easily-manufactured antiviral drugs against COVID-19 and future viral pandemics has received key funding of £8 million from Wellcome, on behalf of the Covid-19 Therapeutics Accelerator.

28 Sep 2021

Novel antibody candidate shows potent binding to diverse SARS-CoV-2 variant mutations

Twist Bioscience Corporation (Nasdaq: TWST) today reported that its internally-discovered antibody candidate TB202-3 (CoVIC-094), demonstrated potent binding to diverse SARS-CoV-2 variant mutations, including strains with the E484K, N501Y, D614G, Y453F and K417N mutations in pseudovirus assays, indicating this therapeutic antibody may be effective in treating many strains of COVID-19.

25 Sep 2021

MD Anderson supports World Cancer Research Day and its efforts to promote cancer research

The University of Texas MD Anderson Cancer Center is proud to support World Cancer Research Day, Sept. 24, and its efforts to promote cancer research as a driving force behind progress in cancer prevention, early detection, treatment, and survivorship.

25 Sep 2021

Peter Adams and Gerald Shadel receive NIH grant to explore the link between aging and liver cancer

Sanford Burnham Prebys professor Peter D. Adams, Ph.D., who directs the Aging, Cancer and Immuno-oncology Program and Salk Institute professor Gerald Shadel, Ph.D., who directs the San Diego Nathan Shock Center of Excellence in the Basic Biology of Aging, have been awarded a grant from the NIH's National Institute on Aging for $13 million, funding a five-year project to explore the connection between aging and liver cancer.

24 Sep 2021

Researchers use new laser-assisted technology for bioprinting adult neuron cells

A group of researchers including a Concordia PhD student have developed a new method of bioprinting adult neuron cells. They're using a new laser-assisted technology that maintains high levels of cell viability and functionality.

22 Sep 2021

Comparison of recombinant SARS-CoV-2 receptor binding domain produced in mammalian, insect, and bacterial cells

In a recent study, RBD produced in various cell types are characterized in-depth, comparing their applicability for future COVID-19 research.

21 Sep 2021

EIT Health highlights the urgent need for harnessing data and AI to fight against Alzheimer’s disease

To coincide with World Alzheimer’s Month, EIT Health, an EU-backed network of best-in-class health innovators, has highlighted the urgent need to focus on implementing bolder approaches to the treatment of Alzheimer’s Disease post-pandemic.

20 Sep 2021

Scientists identify new approach to overcome resistance to cancer immunotherapy

Hokkaido University scientists and colleagues in Japan have found a way that could help some patients overcome resistance to immunotherapy treatment for cancer. The approach, proven in mice experiments, was reported in the Journal for Immunotherapy of Cancer.

17 Sep 2021

Study discovers biological mechanism linking long-term arsenic exposure to cancer, diabetes

A University of Arizona Health Sciences study has identified the biological mechanism linking long-term arsenic exposure to diseases such as cancer and Type 2 diabetes.

15 Sep 2021

Study pinpoints a potential pathway for treating epileptic seizures in patients with autism

Autism affects about 2% of children in the United States, and about 30% of these children have seizures. Recent large-scale genetic studies revealed that genetic variants in a sodium channel, called voltage-gated sodium channel Nav1.2, is a leading cause of autism.

15 Sep 2021

Drug Discovery News and Research

Further Reading

New source of stem cells could help treat people with Alagille syndrome

Novel proteomics approach predicts severe COVID-19 outcomes

Study finds increased risk for SARS-CoV-2 breakthrough infections in people with substance use disorders

Researchers publish new datasets to better train machine learning models for drug discovery

Study investigates long-COVID symptoms in people recovering from COVID-19 infection

Researchers discover working mechanism of potential drug targets for COVID-19

COVID Moonshot receives key funding to accelerate drug discovery efforts

Novel antibody candidate shows potent binding to diverse SARS-CoV-2 variant mutations

MD Anderson supports World Cancer Research Day and its efforts to promote cancer research

Peter Adams and Gerald Shadel receive NIH grant to explore the link between aging and liver cancer

Researchers use new laser-assisted technology for bioprinting adult neuron cells

Comparison of recombinant SARS-CoV-2 receptor binding domain produced in mammalian, insect, and bacterial cells

EIT Health highlights the urgent need for harnessing data and AI to fight against Alzheimer’s disease

Scientists identify new approach to overcome resistance to cancer immunotherapy

Study discovers biological mechanism linking long-term arsenic exposure to cancer, diabetes

Study pinpoints a potential pathway for treating epileptic seizures in patients with autism

Optibrium Releases 3D Ligand-based Design Module for StarDrop Drug Discovery Software

Breakthrough discovery could pave the way for new non-opioid painkillers to treat neuropathic pain

Potential pancoronavirus fusion inhibitors that are effective against SARS-CoV-2 variants

Impact of colloidal aggregation in COVID-19 drug repurposing screens

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