Growth Factor News and Research

RSS

Depriving deadly brain cancer cells of cholesterol causes tumor regression in mouse models

Researchers at University of California San Diego School of Medicine, Ludwig Institute for Cancer Research and The Scripps Research Institute, with colleagues in Los Angeles and Japan, report that depriving deadly brain cancer cells of cholesterol, which they import from neighboring healthy cells, specifically kills tumor cells and caused tumor regression and prolonged survival in mouse models.

13 Oct 2016

Japanese researchers identify mechanism for hormone that limits liver fibrosis

Nonalcoholic steatohepatitis (NASH) has been emerging worldwide and effective treatment, especially for liver fibrosis, is essential for improving the prognosis.

13 Oct 2016

Study suggests possibility for small molecule drug/antibody combinatorial therapy to treat neuroblastoma

A study by a multidisciplinary team of researchers from The Saban Research Institute of Children's Hospital Los Angeles sheds further light on the role of the cytokine TGFβ1 in the growth of neuroblastoma, and suggests the possibility for a small molecule drug/antibody combinatorial therapy to treat this cancer.

12 Oct 2016

New image analysis technique helps better identify and distinguish between two cancer cell types

Brown University researchers have developed a new image analysis technique to distinguish two key cancer cell types associated with tumor progression.

12 Oct 2016

Research on naked mole-rats could pave way for new human pain therapies

In injuries and inflammation, naked mole-rats do not develop normal hypersensitivity to temperature stimuli.

12 Oct 2016

Study of pan-FGFR inhibitor uses mRNA in tumours to identify responders

The first-in-human dose escalation study of the pan-FGFR (fibroblast growth factor receptor) inhibitor BAY 1163877 in patients with treatment-refractory locally advanced or metastatic solid tumours were reported today at the ESMO 2016 Congress in Copenhagen.

8 Oct 2016

Researchers awarded grant to develop safer cancer therapies for children

Two Case Western Reserve University School of Medicine researchers are receiving new funding from California-based St. Baldrick's Foundation for promising childhood cancer research.

5 Oct 2016

Researchers identify new strategy to selectively sensitize cancer cells to radiation therapy

Many types of cancer become drug resistant, making them difficult to treat. Researchers with University of California San Diego School of Medicine and Moores Cancer Center have identified a strategy to selectively sensitize certain cancer cells to radiation therapy that may improve tumor control and reduce treatment-related side effects.

5 Oct 2016

Researchers uncover key factor for promoting wound healing after corneal injuries

In cases of severe ocular trauma involving the cornea, wound healing occurs following intervention, but at the cost of opaque scar tissue formation and damaged vision. Recent research has shown that mesenchymal stem cells (MSCs) — which can differentiate into a variety of cells, including bone, cartilage, muscle and fat cells — are capable of returning clarity to scarred corneas; however, the mechanisms by which this happens remained a mystery — until now.

29 Sep 2016

New study reveals endocrine biological function of brown adipose tissue

Brown adipose tissue -main organ generating heat in the body- is also an endocrine organ that secretes signaling factors that activate the fat and carbohydrates metabolism.

28 Sep 2016

Progesterone treatment protects female mice against consequences of influenza infection

Over 100 million women are on hormonal contraceptives. All of them contain some form of progesterone, either alone or in combination with estrogen.

22 Sep 2016

ATS releases new clinical practice guidelines for diagnosis, management of LAM

The American Thoracic Society and the Japanese Respiratory Society have published new clinical practice guidelines for the diagnosis and management of lymphangioleiomyomatosis (LAM), a rare lung disease that primarily affects women of child-bearing age.

15 Sep 2016

Experimental co-culture approach facilitates study of cellular events underlying Huntington's disease

Using an experimental co-culture approach in which two different types of neurons from a mouse model of Huntington's disease (HD) are grown side-by-side, connecting to form critically impacted circuits, researchers at University of California San Diego School of Medicine have identified a subunit of a protein that, when expressed, reverse the mutated gene effects responsible for HD.

6 Sep 2016

New stem-cell model of heart tissue unravels mechanisms linked to hypertrophic cardiomyopathy

Using advanced stem cell technology, scientists from the Icahn School of Medicine at Mount Sinai have created a model of a heart condition called hypertrophic cardiomyopathy (HCM) — an excessive thickening of the heart that is associated with a number of rare and common illnesses, some of which have a strong genetic component.

31 Aug 2016

Study suggests autologous EPC transfusion may prevent miscarriage in high-risk pregnancies

In a study focusing on the role of self-donated (autologous) bone marrow-derived endothelial progenitor cells (EPCs) in placental vascular development, researchers in Japan have discovered that when transplanted into pregnant mice, EPCs can contribute to better blood vessel growth that helps in forming "normalized" placental vascularization, leading, in turn, to reduced recurrent miscarriages by providing a healthier fetal environment during gestation.

30 Aug 2016

NEJM publishes MINDACT trial results

Agendia, Inc., a world leader in personalized medicine and molecular cancer diagnostics, announces the peer-reviewed publication of the primary outcome results of the Microarray In Node-negative and 1 to 3 positive lymph node Disease may Avoid ChemoTherapy (MINDACT) clinical trial in the prestigious New England Journal of Medicine (NEJM). (i, iii, iv) The publication demonstrates that 46% of breast cancer patients considered for chemotherapy, whose tumors are classified MammaPrint Low Risk, have excellent survival without chemotherapy, and can thus be candidates to avoid this toxic therapy.

29 Aug 2016

Skin cells derived from autistic donors grow faster than those from control subjects

Brain cells grow faster in children with some forms of autism due to distinct changes in core cell signaling patterns, according to research from the laboratory of Anthony Wynshaw-Boris, MD, PhD, chair of the department of genetics and genome sciences at Case Western Reserve University School of Medicine.

28 Aug 2016

People with high levels of four biomarkers may have increased risk for stroke

People with high levels of four biomarkers in the blood may be more likely to develop a stroke than people with low levels of the biomarkers, according to a study published in the August 24, 2016, online issue of Neurology, the medical journal of the American Academy of Neurology.

25 Aug 2016

Scientists discover less invasive, cheaper technique to improve woman's chances of becoming pregnant

For those facing infertility, IVF has long been the established option to have a baby. Now Australian and Belgian medical scientists have discovered how to improve a woman's chances of becoming pregnant using a less invasive and cheaper alternative.

23 Aug 2016

Novel material heals diabetic wounds faster than standard bandage

At some point in their lives, 15 percent of people with diabetes will develop a painful and hard-to-treat foot ulcer.

18 Aug 2016

Growth Factor News and Research

Depriving deadly brain cancer cells of cholesterol causes tumor regression in mouse models

Japanese researchers identify mechanism for hormone that limits liver fibrosis

Study suggests possibility for small molecule drug/antibody combinatorial therapy to treat neuroblastoma

New image analysis technique helps better identify and distinguish between two cancer cell types

Research on naked mole-rats could pave way for new human pain therapies

Study of pan-FGFR inhibitor uses mRNA in tumours to identify responders

Researchers awarded grant to develop safer cancer therapies for children

Researchers identify new strategy to selectively sensitize cancer cells to radiation therapy

Researchers uncover key factor for promoting wound healing after corneal injuries

New study reveals endocrine biological function of brown adipose tissue

Progesterone treatment protects female mice against consequences of influenza infection

ATS releases new clinical practice guidelines for diagnosis, management of LAM

Experimental co-culture approach facilitates study of cellular events underlying Huntington's disease

New stem-cell model of heart tissue unravels mechanisms linked to hypertrophic cardiomyopathy

Study suggests autologous EPC transfusion may prevent miscarriage in high-risk pregnancies

NEJM publishes MINDACT trial results

Skin cells derived from autistic donors grow faster than those from control subjects

People with high levels of four biomarkers may have increased risk for stroke

Scientists discover less invasive, cheaper technique to improve woman's chances of becoming pregnant

Novel material heals diabetic wounds faster than standard bandage

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Applications Engineer

Latest News