Mutation News and Research

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Screening cultured stem cells for genetic mutations could ensure the accuracy of disease models

Induced pluripotent stem cells offer great therapeutic potential and are a valuable tool for understanding how different diseases develop.

24 Mar 2023

Genes known to control eye color are essential for retinal health

Metabolic pathways consist of a series of biochemical reactions in cells that convert a starting component into other products.

23 Mar 2023

Candida auris infection without epidemiologic links to a prior outbreak

The Centers for Disease Control and Prevention (CDC) has classified Candida auris (C. auris) as an urgent public threat due to its role in elevating mortality, its ability to persist in hospital environments, and the high possibility of developing pan-drug resistance.

23 Mar 2023

Discovery suggests a new way to treat spinal muscular atrophy

Columbia researchers have discovered how a genetic defect leads to spinal muscular atrophy (SMA), a critical piece of information about the disease that neurologists have been seeking for decades.

23 Mar 2023

Pet dogs across the USA are becoming increasingly resistant to benzimidazole treatment

In a recent study published in the journal PLOS Pathogens, researchers in the United States of America (USA) and Canada found molecular evidence that the parasitic hookworms (Ancylostoma caninum) in pet dogs across the USA are becoming increasingly resistant to benzimidazole, a broad-spectrum anthelmintic drug used for infection control.

22 Mar 2023

Emergence and persistency of SARS-CoV-2 Omicron BA.2.3.7 in Taiwan

Researchers utilize whole-genome surveillance to monitor community transmission and evolution of SARS-CoV-2 in Taiwan.

22 Mar 2023

Researchers discover how a mutation in the desmosomal gene leads to arrhythmogenic cardiomyopathy

Mutations in genes that form the desmosome are the most common cause of the cardiac disease arrhythmogenic cardiomyopathy (ACM), which affects one in 2000 to 5000 people worldwide.

22 Mar 2023

Tetravalent COVID vaccine provides broad antibody responses against SARS-CoV-2 variants in animal model

In a recent study posted to the bioRxiv* preprint server, researchers in Italy and the United States evaluated the efficacy and immunogenicity of an adjuvanted tetravalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein subunit 1 (S1) COVID-19 vaccine.

21 Mar 2023

Avanced genome editing technology could be used as a one-time treatment for CD3 delta SCID

A new UCLA-led study suggests that advanced genome editing technology could be used as a one-time treatment for the rare and deadly genetic disease CD3 delta severe combined immunodeficiency.

21 Mar 2023

Novel RNA sense-and-respond circuit harnesses the force of enzymes to develop better drugs

More than twelve billion doses of mRNA vaccines have been administered globally since the start of the COVID pandemic, saving millions of lives. But RNA-based therapies for other diseases have so far proven more challenging to develop.

20 Mar 2023

New SARS-CoV-2 Omicron XBB.1.5 variant has high transmissibility and infectivity, study finds

COVID-19 has caused significant global panic after its rapid emergence more than 3 years ago. Although we now have highly effective vaccines against the SARS-CoV-2 virus, which causes COVID-19, scientists continue to study emerging SARS-CoV-2 variants in order to safeguard public health and devise global preventive strategies against emerging variants.

20 Mar 2023

CRISPR-based genome editing restores the vision of mice with retinitis pigmentosa

Researchers in China have successfully restored the vision of mice with retinitis pigmentosa, one of the major causes of blindness in humans.

17 Mar 2023

How the structural and functional effects of mutations on androgen receptor lead to prostate cancer

The androgen receptor is a key transcriptional factor for the proper sex development —specially in males— and the physiological balance of all the tissues that express this receptor.

17 Mar 2023

Anti-Omicron antibodies are induced by hypermutation with ancestral BNT162b2 COVID vaccine

Scientists from the Republic of Korea have analyzed B-cell receptor repertoires induced by an mRNA-based coronavirus disease 2019 (COVID-19) vaccine and found that somatic hypermutations in B-cell receptor heavy chain are responsible for broadening its specificity for unexposed antigens.

16 Mar 2023

One-Pot-LAMP: A promising tool for non-small cell lung cancer diagnosis

Researchers assessed the efficiency of a genetic decoding system for diagnosing non-small cell lung cancer (NSCLC).

16 Mar 2023

Estrogen may increase the risk of certain types of arrhythmia

The sex hormone estrogen has a negative impact on heartbeat regulation, according to an experimental study from Linköping University, Sweden, published in Science Advances.

15 Mar 2023

Study demonstrates long-term safety and clinical benefit of combination therapy for cystic fibrosis

Patients with cystic fibrosis (CF) face difficulty breathing and a decline in lung function and are at risk of early death. CF is an inherited condition that results in thick mucus build-up, persistent infection and inflammation in the lungs.

15 Mar 2023

Embryonic stem cells used to recreate thyroid cancer histotypes

A recent Nature Communications study revealed the recapitulating capacity of human embryonic stem cells (hESCs) to elucidate the cellular hierarchy of the thyroid gland. Furthermore, these cells possessed the capacity to reproduce the oncogenic process using the CRISPR-based genetic editing method.

14 Mar 2023

Specific enzyme produced in liver cancer cells could turn a molecule into potential anticancer drug

Scientists at the National Institutes of Health and Massachusetts General Hospital in Boston have uncovered a potential new approach against liver cancer that could lead to the development of a new class of anticancer drugs.

14 Mar 2023

New influenza virus strain concocted in animals could be the cause of next human pandemic

The next pandemic that cascades through the human population could be caused by a new influenza virus strain concocted in animals, against which humans will have little to no immunity.

13 Mar 2023

Mutation News and Research

Screening cultured stem cells for genetic mutations could ensure the accuracy of disease models

Genes known to control eye color are essential for retinal health

Candida auris infection without epidemiologic links to a prior outbreak

Discovery suggests a new way to treat spinal muscular atrophy

Pet dogs across the USA are becoming increasingly resistant to benzimidazole treatment

Emergence and persistency of SARS-CoV-2 Omicron BA.2.3.7 in Taiwan

Researchers discover how a mutation in the desmosomal gene leads to arrhythmogenic cardiomyopathy

Tetravalent COVID vaccine provides broad antibody responses against SARS-CoV-2 variants in animal model

Avanced genome editing technology could be used as a one-time treatment for CD3 delta SCID

Novel RNA sense-and-respond circuit harnesses the force of enzymes to develop better drugs

New SARS-CoV-2 Omicron XBB.1.5 variant has high transmissibility and infectivity, study finds

CRISPR-based genome editing restores the vision of mice with retinitis pigmentosa

How the structural and functional effects of mutations on androgen receptor lead to prostate cancer

Anti-Omicron antibodies are induced by hypermutation with ancestral BNT162b2 COVID vaccine

One-Pot-LAMP: A promising tool for non-small cell lung cancer diagnosis

Estrogen may increase the risk of certain types of arrhythmia

Study demonstrates long-term safety and clinical benefit of combination therapy for cystic fibrosis

Embryonic stem cells used to recreate thyroid cancer histotypes

Specific enzyme produced in liver cancer cells could turn a molecule into potential anticancer drug

New influenza virus strain concocted in animals could be the cause of next human pandemic

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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