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Combination treatment extends progression-free survival in advanced skin cancer

In patients with an advanced type of skin cancer called cutaneous squamous cell carcinoma (cSCC), those who received the combination of the immunotherapy drug avelumab and targeted agent cetuximab had almost four times longer median progression-free survival compared to patients who received avelumab alone, according to the results of a phase 2 trial presented today at the American Society of Clinical Oncology (ASCO) meeting and concurrently published in the Journal of Clinical Oncology.

1 Jun 2025

Leading health organizations release guidance on nutrition support for GLP-1 obesity therapies

Four leading organizations in lifestyle medicine, obesity medicine, and nutrition-the American College of Lifestyle Medicine (ACLM), the American Society for Nutrition (ASN), the Obesity Medicine Association (OMA), and The Obesity Society (TOS)-have jointly released a clinical advisory titled "Nutritional Priorities to Support GLP-1 Therapy for Obesity."

31 May 2025

Universal CAR T cell therapy shows promise for aggressive T cell cancers

A new type of immunotherapy that targets aggressive blood cancers shows promising results alongside manageable side effects, according to the results of an international phase 1/2 clinical trial led by researchers at Washington University School of Medicine in St. Louis.

31 May 2025

Navigating the challenges and progress in dengue vaccine development

Dengue fever caused by a flavivirus named DENV is a major global health challenge, risking almost half of the world's population. Since the early 20th century, the scientific community has faced multiple challenges to develop effective dengue vaccines.

30 May 2025

TTF1 identified as key biomarker for advanced KRAS G12C-mutated non-small cell lung cancer

Researchers from The University of Texas MD Anderson Cancer Center have identified a new biomarker, TTF-1, that was predictive of survival outcomes for patients with advanced KRAS G12C-mutated non-small cell lung cancer (NSCLC), following treatment with the KRAS targeted therapy sotorasib.

30 May 2025

What drives insulin resistance? Proteomics reveals key pathways in human skeletal muscle

Identifying proteomic signatures of insulin resistance in fasting muscle offers insights for personalized type 2 diabetes therapies based on molecular profiles.

30 May 2025

Early allergen introduction reduces childhood food allergy risk

Investigating allergy prevention, this research highlights early intervention strategies and the promise of biologic treatments in managing allergic conditions.

29 May 2025

New discovery reveals how cohesin complex alters gene expression

Cohesin is a protein that forms a ring-shaped complex which wraps and alters the DNA molecule shape. It moves through the DNA and creates specific loops in the genetic material which determine the architecture of the genome and gene expression.

29 May 2025

New mouse model sheds light on molecular triggers of aortic dissection

Due to the sudden rupture of the aortic wall, aortic dissection is a life-threatening condition that requires immediate medical attention, as it can lead to vascular collapse.

29 May 2025

Choosing better carbs in low-carb diets boosts health outcomes

A long-term study of the Framingham Heart Study Offspring cohort found that low-carbohydrate diets emphasizing high-quality carbs, like whole grains, fruits, and vegetables, were linked to reduced inflammation and oxidative stress. Diets low in carbohydrate quality offered no such benefits.

29 May 2025

New four drug combination sets new standard in myeloma care

A new four-drug combination is highly effective and safe in patients with newly diagnosed multiple myeloma, according to data presented at the annual meeting of the American Society of Clinical Oncology, held May 30 through June 3 in Chicago.

29 May 2025

Muscle wasting in cancer tied to blood vessel dysfunction

A dysfunction in muscle blood vessels could be to blame for the weak muscles and weight loss that most cancer patients experience, according to a new study from University of Illinois Chicago researchers.

29 May 2025

New peptide therapy shows promise against glioblastoma recurrence

A lab-designed molecule developed and extensively studied by scientists with Virginia Tech's Fralin Biomedical Research Institute at VTC could represent a breakthrough in slowing tumor recurrence in glioblastoma, an aggressive and deadly form of brain cancer.

29 May 2025

UVA researchers discover key to HIV latency and reactivation

University of Virginia School of Medicine scientists have uncovered a key reason why HIV remains so difficult to cure: Their research shows that small changes in the virus affect how quickly or slowly it replicates, and how easily or stubbornly it can reawaken from hiding.

29 May 2025

Study identifies C5aR1 as a key marker of metastasis in skin cancer

Researchers have identified C5aR1 as a novel biomarker for metastasis risk and poor prognosis in patients with cutaneous squamous cell carcinoma (cSCC), the most common type of metastatic skin cancer.

29 May 2025

Innovative technology simplifies T cell harvesting for cancer immunotherapy

CAR T cell immunotherapy, which uses a patient's own modified immune cells to find and destroy cancer cells, can produce dramatic results when treating blood cancers like lymphoma and leukemia and shows promise against solid tumors.

29 May 2025

Breakthrough study finds genes behind calcium pyrophosphate deposition disease

In a first-of-its-kind genome-wide association study (GWAS) researchers have discovered two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition (CPPD) disease in Americans of European and African descent.

28 May 2025

Stress granules play a protective role against neurodegenerative disease

Scientists from St. Jude Children's Research Hospital and Washington University in St. Louis report mechanistic insights into the role of biomolecular condensation in the development of neurodegenerative disease.

28 May 2025

New injection therapy can lead to long lasting blood pressure reduction

Results from a clinical trial led by researchers from Queen Mary University of London, published today in JAMA, show that giving people with high blood pressure an injection every six months can lead to a meaningful, sustained reduction in their blood pressure.

28 May 2025

High fat diet disrupts metabolism and increases disease risk

Consuming a high-fat diet can lead to a variety of health problems - not only weight gain but also an increased risk of diabetes and other chronic diseases.

28 May 2025