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Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Researchers presented eight hallmarks of neurodegenerative diseases (NDDs), their in vivo biomarkers, and interactions to help categorize NDDs and specify patients within a specific NDD.

21 Feb 2023

Propylene glycol prevents airborne transmission of respiratory viruses

Researchers assess the ability of propylene glycol to inactivate infection caused by respiratory viruses and prevent airborne transmission.

20 Feb 2023

Genome editing prevents hypertrophic cardiomyopathy in mice

In a recent study published in the journal PLoS Digital Health, researchers pursued one-time cures for hypertrophic cardiomyopathy (HCM). They used a previously constructed murine model of HCM, designated as R403Q-129SvEv, to evaluate two different genetic therapies, as follows:

19 Feb 2023

Research reports full efficacy of Sotrovimab against BQ.1.1 viral replication in a non-human primate challenge model

Researchers used a non-human primate model to show that Sotrovimab, a commercial mAb also known as Xevudy, was fully effective against SARS-CoV-2 Omicron BA.5 sub-lineage and its derivatives, such as BQ.1.1.

17 Feb 2023

An oral and on-demand male contraceptive

Researchers identify a soluble adenylyl cyclase (sAC) inhibitor that has the potential to be used as an on-demand oral contraceptive for men.

16 Feb 2023

Penn engineers address the longstanding gap in reproductive health care with targeted RNA therapy

Pre-eclampsia is a leading cause of stillbirths and prematurity worldwide, occurring in 3 – 8 % of pregnancies. A disorder characterized by high maternal blood pressure, it results from insufficient vasodilation in the placenta, restricting blood flow from the mother to the fetus.

16 Feb 2023

Inventia Life Science collaborates with MSD to develop 3D advanced cell models for neurodegenerative disease drug discovery

Inventia Life Science, a world leader in advanced cell models for biomedical research and drug discovery, today announced a collaboration with MSD (tradename of Merck & Co., Inc., Rahway, N.J., USA) using Inventia’s RASTRUM™ 3D cell culture platform.

From Inventia Life Science 16 Feb 2023

Jamaican fruit bat's response to SARS-CoV-2 adapted to human

In a recent study posted to the bioRxiv* server, researchers examined the vulnerability of Jamaican fruit bats (Artibeus jamaicensis) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

15 Feb 2023

Protein degradation approach can be used to hit an ‘undruggable’ target against cancer

The protein STAT5 has long been an appealing target against cancer, but after decades of research it was consigned to the "undruggable" category.

15 Feb 2023

Novel predictive index for gastric cancer prognosis

A new research paper was published in Oncotarget's Volume 14 on January 31, 2023, entitled, "Novel inflammation-combined prognostic index to predict survival outcomes in patients with gastric cancer."

15 Feb 2023

Active compound in Lion’s Mane mushroom improves nerve growth and memory

Scientists report that the active compound from an edible mushroom, Hericium erinaceus, can enhance nerve growth and boost memory.

13 Feb 2023

Researchers report a physical barrier against SARS-CoV-2 infection based on an inhalable bioadhesive hydrogel

Researchers developed spherical hydrogel inhalation for enhanced lung defense to protect against SARS-CoV-2 infections.

13 Feb 2023

The immunogenicity of two leading malaria vaccine candidates delivered as mRNA-LNP vaccines

Researchers evaluated the immunogenicity of two vaccine candidates, Pfs25 and PfCSP, based on the mRNA-lipid nanoparticle (LNP) platform.

13 Feb 2023

Whole-genome CRISPR activation for the identification of host factors controlling cellular interactions with SARS-CoV-2

Researchers found that LRRC15, a TLR-related cell surface receptor, blocked SARS-CoV-2 spike binding.

13 Feb 2023

High-precision mechanical sensing system can measure in vivo biomechanical properties of tissue, single cell

Fiber sensing scientists at Shenzhen University have developed a compact fiber optical nanomechanical probe (FONP) for measuring in vivo biomechanical properties of tissue and even single cell.

10 Feb 2023

β-damascone can function as an efficient modulator of dendritic cell-mediated functions

Dendritic cells (DCs) are important players of the immune system with important functions such as the identification of infectious pathogens, production of cytokines (chemical signalers of the immune system), presentation of antigens to activate T-cells, and more.

10 Feb 2023

Personalizing CAR-T cell stimulation during manufacturing can enhance its functionality

New adoptive T cell therapies - in which T cells, the immune system's natural hunters patrolling the body for foreign adversaries, are retrieved from cancer-riddled patients, super-charged and amplified outside the body, and then infused back into the same patient - are changing the prospects of cancer patients.

10 Feb 2023

in vivo News and Research

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Propylene glycol prevents airborne transmission of respiratory viruses

Genome editing prevents hypertrophic cardiomyopathy in mice

Research reports full efficacy of Sotrovimab against BQ.1.1 viral replication in a non-human primate challenge model

An oral and on-demand male contraceptive

Penn engineers address the longstanding gap in reproductive health care with targeted RNA therapy

Inventia Life Science collaborates with MSD to develop 3D advanced cell models for neurodegenerative disease drug discovery

Jamaican fruit bat's response to SARS-CoV-2 adapted to human

Protein degradation approach can be used to hit an ‘undruggable’ target against cancer

Novel predictive index for gastric cancer prognosis

Active compound in Lion’s Mane mushroom improves nerve growth and memory

Researchers report a physical barrier against SARS-CoV-2 infection based on an inhalable bioadhesive hydrogel

The immunogenicity of two leading malaria vaccine candidates delivered as mRNA-LNP vaccines

Whole-genome CRISPR activation for the identification of host factors controlling cellular interactions with SARS-CoV-2

High-precision mechanical sensing system can measure in vivo biomechanical properties of tissue, single cell

β-damascone can function as an efficient modulator of dendritic cell-mediated functions

Personalizing CAR-T cell stimulation during manufacturing can enhance its functionality

Molecular switch regulates autophagy in plants

Casein-based diet found to protect diabetic mice against autoimmunity

New compound limits the replication of influenza viruses

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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