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New AF267B drug reverses key cognitive deficits, pathology in Alzheimer's

A new drug that enhances the activity of a key brain cell receptor involved in Alzheimer's disease (AD) reverses learning and memory deficits in mice engineered to have pathological hallmarks of the disease.

13 Mar 2006

Stroke researchers have traced the major cause of the death of brain cells

In the neurological train wreck that is stroke, researchers have traced the major cause of the death of brain cells due to artery blockage or bleeding in the brain.

13 Mar 2006

A more accurate method for measuring blood levels of endothelial progenitor cells

A more accurate method for measuring blood levels of specialized cells that circulate in the bloodstream and repair damage to the arterial lining has been discovered by Duke University Medical Center cardiologists.

13 Mar 2006

A map of recent positive selection in the human genome

By scanning the entire human genome in search of genetic variations that may signal recent evolution, University of Chicago researchers found more than 700 genetic variants that may be targets of recent natural positive selection during the past 10,000 years of human evolution.

13 Mar 2006

Completely novel approach to fighting HIV infections

For more than a year, researchers watched patiently as a few computer-simulated HIV protease molecules squirmed into more than 15,000 slightly different shapes. In real time, this contortion takes only a fraction of a second.

13 Mar 2006

New test for detecting small amounts of proteins in the blood

Researchers at the University of Pennsylvania School of Medicine have developed a paradigm-shifting method for detecting small amounts of proteins in the blood.

13 Mar 2006

Trial explores safety and efficacy of injecting human stem cells directly into the brain to treat fatal pediatric neurodegenerative disorder

Researchers in Doernbecher Children's Hospital at Oregon Health & Science University will begin a Phase I clinical trial using stem cells in infants and children with a rare neurodegenerative disorder that affects infants and children.

13 Mar 2006

Genetic switch that turns off an oxygen-poor cell's combustion engine - finding has potential to limit toxic molecules

Johns Hopkins researchers have discovered a previously unrecognized role played by the gene HIF-1 as it helps cell survive when a lack of oxygen decreases production of an energy-rich molecule called ATP and increases production of toxic molecules.

9 Mar 2006

How mammalian brains recognize other individuals

Imagine seeing a former high school classmate you always wanted to know better. Then imagine seeing that kid who used to push you in the hallways. Do you react differently? What happens in your brain during these encounters?

9 Mar 2006

Link between coffee consumption and risk of myocardial infarction greater with certain gene variation

Individuals who have a genetic variation associated with slower caffeine metabolism appear to have an increased risk of non-fatal heart attack associated with higher amounts of coffee intake

9 Mar 2006

Test for LDH enzyme may help determine risk factors in sickle cell disease

Researchers have found that a simple test for an enzyme called LDH may have significant importance for determining major risk factors in adults with sickle cell disease.

9 Mar 2006

Metabolic switch required for cellular adaptation to hypoxia

Two new studies in the March Cell Metabolism reveal a survival mechanism by which cells adapt to oxygen starvation by ratcheting down their demand.

9 Mar 2006

Coffee good or bad for you? It depends on your genes!

Scientists know that coffee, a major source of caffeine, is metabolized by the enzyme, cytochrome P450 1A2, and some individuals who have that particular gene are "rapid" caffeine metabolizers, whereas those with a different variation of the gene are "slow" caffeine metabolizers.

8 Mar 2006

Discovery of compound that reduces hallmark lesions of Alzheimer's disease in mice

Researchers at UC Irvine have found that a new compound not only relieves the cognitive symptoms of Alzheimer's disease, but also reduces the two types of brain lesions that are hallmarks of this devastating disease, thereby blocking its progression.

7 Mar 2006

Genes play a key role in stress response

Both nature and nurture - genetic makeup and the environment experienced through life - combine to influence health and well-being, Duke University Medical Center researchers and their colleagues have determined in four new studies.

7 Mar 2006

Gene therapy approach used in creating new arteries for older patients does not appear to cause cancer

"This result is an encouraging step along the road to new tissues for patients to replace those that have failed or have been destroyed due to trauma or disease," she said.

7 Mar 2006

Johns Hopkins scientists identify protein fragment which may lead to a simple test for multiple sclerosis

Johns Hopkins scientists report the discovery of a protein found only in cerebrospinal fluid that they say might be useful in identifying a subgroup of patients with multiple sclerosis (MS) or identifying those at risk for the debilitating autoimmune disorder.

7 Mar 2006

Simple saliva test may offer a new way to probe the consequences of caffeine coupled with stress

Using doses of caffeine equivalent to drinking one to four cups of coffee and an intense arithmetic test as stressors, Klein and her colleagues found a rise in the amount of alpha amylase, an enzyme secreted by the salivary glands, in the healthy young men who participated in the study.

7 Mar 2006

Genome signature tagging used to quickly identify and distinguish between pathogens and harmless microbes

Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have developed a new, high-throughput technique for identifying the many species of microorganisms living in an unknown "microbial community."

6 Mar 2006

The incidence, distribution, and control of tuberculosis

A reduction in tuberculosis (TB) incidence, prevalence and death rate can be achieved by 2015 in most parts of the world, with the greatest challenges occurring in Africa and Eastern Europe, according to a projection by the Stop TB Department of the World Health Organization.

1 Mar 2006

Enzyme News and Research

New AF267B drug reverses key cognitive deficits, pathology in Alzheimer's

Stroke researchers have traced the major cause of the death of brain cells

A more accurate method for measuring blood levels of endothelial progenitor cells

A map of recent positive selection in the human genome

Completely novel approach to fighting HIV infections

New test for detecting small amounts of proteins in the blood

Trial explores safety and efficacy of injecting human stem cells directly into the brain to treat fatal pediatric neurodegenerative disorder

Genetic switch that turns off an oxygen-poor cell's combustion engine - finding has potential to limit toxic molecules

How mammalian brains recognize other individuals

Link between coffee consumption and risk of myocardial infarction greater with certain gene variation

Test for LDH enzyme may help determine risk factors in sickle cell disease

Metabolic switch required for cellular adaptation to hypoxia

Coffee good or bad for you? It depends on your genes!

Discovery of compound that reduces hallmark lesions of Alzheimer's disease in mice

Genes play a key role in stress response

Gene therapy approach used in creating new arteries for older patients does not appear to cause cancer

Johns Hopkins scientists identify protein fragment which may lead to a simple test for multiple sclerosis

Simple saliva test may offer a new way to probe the consequences of caffeine coupled with stress

Genome signature tagging used to quickly identify and distinguish between pathogens and harmless microbes

The incidence, distribution, and control of tuberculosis

Understanding the DNA Damage Response in Innate Immunity eBook

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