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Scientists invent way to reversibly silence brain cells using pulses of yellow light

Scientists at the MIT Media Lab have invented a way to reversibly silence brain cells using pulses of yellow light, offering the prospect of controlling the haywire neuron activity that occurs in diseases such as epilepsy and Parkinson's disease.

2 Apr 2007

Synthesis, characterization, DNA binding and in vivo activity of Ru(II)/Pt(II) complexes

Chemists and biologists at Virginia Tech continuing to design light-activated molecular systems to attack cancer cells have introduced a DNA targeting component.

2 Apr 2007

Validation of an LED array for use in DNA photocleavage assays

Biology and chemistry researchers from Virginia Tech are creating molecular complexes to bind to and disrupt the DNA of diseased tissues, such as tumors or viruses.

2 Apr 2007

Reconstituted HDL may have some benefit in coronary atherosclerosis

Preliminary research suggests that use of reconstituted HDL may have some benefit in coronary atherosclerosis, according to a JAMA study published online March 26.

2 Apr 2007

Breakthrough research finds genes which may help smoking cessation

Scientists supported by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, have for the first time identified genes that might increase a person's ability to abstain from smoking.

2 Apr 2007

Penn State scientists reveal structure of gateways to gene control

Scientists at Penn State University will reveal in the 29 March 2007 issue of the journal Nature the first complete high-resolution map of important structures that control how genes are packaged and regulated throughout an entire genome.

31 Mar 2007

New cardiovascular treatment approaches

In an era of increasing death and illness from heart and blood vessel disease - which also can impair kidney function - Mayo Clinic researchers have designed two promising new cardiovascular treatment approaches.

30 Mar 2007

Brain's immune system plays protective role in early Alzheimer's disease

The immune system's response against amyloid-beta, the protein that forms plaques in the brains of patients with Alzheimer's disease, appears to protect the brain from damage in early stages of the devastating neurological disorder.

30 Mar 2007

First time observing real-time molecular interplay within ribosome

The ribosome is a kind of factory for protein in the cell, and as such has long been a prime target for drug discovery. Now, a technological advance by a team at Weill Cornell Medical College is poised to revolutionize research in the field.

21 Mar 2007

Newly discovered peptide could help transplant for diabetes

A peptide developed by scientists at Weill Cornell Medical College may expand the availability and durability of islet cell transplant for patients with type-1 diabetes, which is characterized by a lack of these insulin-producing cells.

21 Mar 2007

Curry related compound shows promise against Kennedy's disease

Scientists who focus on the molecular signaling that underlies prostate cancer have discovered a compound that shows promise against a debilitating neurodegenerative condition known as Kennedy's disease, which is caused by a mutant gene.

21 Mar 2007

Scientists discover new approach for treating virus-induced lymphomas

Kaposi's sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi's sarcoma and primary effusion lymphoma (PEL). PELs are aggressive lymphomas with reported median survival time shorter than six months after diagnosis.

19 Mar 2007

Scientists decipher a signaling pathway crucially involved in Crohn's disease and ulcerative colitis

Inflammatory bowel diseases, such as Crohn's disease and Ulcerative Colitis, severely impair the lives of more than four million people worldwide. The development of effective therapies against these diseases requires an understanding of their underlying molecular mechanisms.

15 Mar 2007

Tykerb (lapatinib) - new anti-cancer treatment approved

The Food and Drug Administration (FDA) has approved Tykerb (lapatinib), a new targeted anti-cancer treatment, to be used in combination with capectabine (Xeloda), another cancer drug, for patients with advanced, metastatic breast cancer that is HER2 positive (tumors that exhibit HER2 protein).

14 Mar 2007

Two novel therapies for multiple myeloma

Two novel biologics are currently being investigated for their potential benefit to multiple myeloma patients in separate ongoing clinical trials at NewYork-Presbyterian Hospital/Weill Cornell Medical Center.

14 Mar 2007

Disorderly protein brings order to cell division

The secret to the ability of a molecule critical for cell division to throw off the protein yoke that restrains its activity is the yoke itself - a disorderly molecule that seems to have a mind of its own, say investigators at St. Jude

13 Mar 2007

New drug target for herpes viruses

Scientists in the lab of Whitehead Institute Member Hidde Ploegh and the Harvard University lab of Rachelle Gaudet have solved the complex structure of a recently discovered protein that is found in a wide range of herpes viruses. This protein may prove to be a potential drug target.

11 Mar 2007