B Cell News and Research

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Study offers insights into how Shigella delivers bacterial proteins into our cells

Shigella, a bacterial pathogen that causes dysentery and is the leading cause of childhood diarrheal diseases, inserts a pore called a translocon into an infected person's intestinal cells and then injects bacterial proteins into the cells.

24 Nov 2021

New "image analysis pipeline" provides insight into how disease changes the body

A new "image analysis pipeline" is giving scientists rapid new insight into how disease or injury have changed the body, down to the individual cell.

24 Nov 2021

Vaccine-induced immune responses for SARS-CoV-2 in patients receiving anti-CD20 B-cell depleting therapies

A new study published on the medRxiv* preprint server analyzed the trajectories of anti-SARS-CoV-2 antibodies in patients from the RituxiVac study were compared to healthy volunteers. In addition, they investigated the immunogenicity of a third vaccine dose in previously non-responding patients.

23 Nov 2021

New therapeutic approach prevents growth of metastatic tumors by putting cancer cells to sleep

A new therapeutic approach prevents the growth of metastatic tumors in mice by forcing cancer cells into a dormant state in which they are unable to proliferate.

23 Nov 2021

Study explains why moles can change into melanoma

Moles and melanomas are both skin tumors that come from the same cell called melanocytes. The difference is that moles are usually harmless, while melanomas are cancerous and often deadly without treatment.

23 Nov 2021

New virtual reality platform could revolutionize the way single-cell omics data is analyzed

Science has the technology to measure the activity of every gene within a single individual cell, and just one experiment can generate thousands of cells worth of data.

23 Nov 2021

Discovery of a broad-spectrum antiviral activity in self-assembling immunostimulatory duplex RNAs

A new study, published on the bioRxiv* preprint server, has discovered a class of new immunostimulatory RNAs while studying influenza infection-associated host genes in human lung epithelial cells using small interfering RNAs (siRNAs). Scientists revealed that these short duplex RNAs could induce type I and type III interferons (IFN-I/III) in a wide variety of cells.

23 Nov 2021

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

A new study, published on the bioRxiv* preprint server, has focused on public clonotypes, i.e., clones found in multiple individuals, for the development of a novel reverse epitope discovery technique. This technique holds greater potential for population-wide applications.

23 Nov 2021

Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2

A new study evaluates the efficacy of SNX-5422 as a post-exposure prophylactic treatment.

23 Nov 2021

Strong antibody responses against harmless coronaviruses may protect against SARS-CoV-2

Infections with the novel coronavirus and vaccination lead to strong antibody responses against SARS-CoV-2. Immune responses to other human coronaviruses, which mostly only cause harmless colds, also provide some protection against SARS-CoV-2.

23 Nov 2021

SARS-CoV-2 moves between permissive cells and non-permissive neuronal cells via tunneling nanotubes (TNT)

Scientists investigate the neuroinvasive potential of SARS-CoV-2 and the role of tunneling nanotubes (TNTs) in spreading the infection to neighboring cells.

23 Nov 2021

New combination of drugs could break down harmful protein aggregates in Parkinson's disease

A new combination of drugs could fix the broken lysosomal enzyme pathway in Parkinson's disease-afflicted brain cells, according to a Northwestern Medicine study published in Neuron.

23 Nov 2021

Novel protein regulator of tumor angiogenesis may be a therapeutic target for difficult-to-treat cancers

A novel protein regulator of tumor angiogenesis, TMEM230, was recently characterized by researchers to have a role in tumor development and vascularization, with potential as a target for anti-tumor therapy in difficult-to-treat cancers such as glioblastoma.

23 Nov 2021

AI identifies patterns on CT scans that offer new promise for treating small cell lung cancer

Researchers at the Center for Computational Imaging and Personalized Diagnostics at Case Western Reserve University have used artificial intelligence (AI) to identify patterns on computed tomography (CT) scans that offer new promise for treating patients with small cell lung cancer.

23 Nov 2021

B Cell News and Research

Study offers insights into how Shigella delivers bacterial proteins into our cells

New "image analysis pipeline" provides insight into how disease changes the body

Vaccine-induced immune responses for SARS-CoV-2 in patients receiving anti-CD20 B-cell depleting therapies

New therapeutic approach prevents growth of metastatic tumors by putting cancer cells to sleep

Study explains why moles can change into melanoma

New virtual reality platform could revolutionize the way single-cell omics data is analyzed

Discovery of a broad-spectrum antiviral activity in self-assembling immunostimulatory duplex RNAs

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2

Strong antibody responses against harmless coronaviruses may protect against SARS-CoV-2

SARS-CoV-2 moves between permissive cells and non-permissive neuronal cells via tunneling nanotubes (TNT)

New combination of drugs could break down harmful protein aggregates in Parkinson's disease

Novel protein regulator of tumor angiogenesis may be a therapeutic target for difficult-to-treat cancers

AI identifies patterns on CT scans that offer new promise for treating small cell lung cancer

Inactivated virion-based vaccine confers robust cell-mediated immunity against major SARS-CoV-2 variants

An increase in the half-life of remdesivir for COVID-19 treatment

Does SARS-CoV-2 infection contribute to adrenal gland dysfunction?

Study shows SARS-CoV-2 can infect and replicate in human iPSC-derived neurons

Interferon beta versus the SARS-CoV-2 Delta variant

IFITM proteins are important replication cofactors for SARS-CoV-2, including Delta variant

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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