Immune System News and Research

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First Edition: September 4, 2014

Today's headlines include reports about a new government report that predicts a rebound in national health spending.

4 Sep 2014

Findings may help develop biomarkers to identify HIV patients at risk of dementia

Since the introduction of the combination anti-retroviral therapy (cART) in the mid-90s, the life expectancy of HIV patients has significantly improved. As a result, long-term complications are becoming more relevant: almost every second HIV patient is affected by neurocognitive disorders, which can lead to dementia.

4 Sep 2014

Study investigates whether function of intestines attacked in MS

The present study investigates whether the function of the intestines is also attacked in MS. The results, obtained from a disease model of MS in mice, shows inflammation and changes in the barrier function of the intestines early in the course of the disease.

4 Sep 2014

Scientists aim to develop rapid test system for immune dysfunction to treat cystic fibrosis

Cystic fibrosis (CF) is a frequent genetic disease affecting the lung and the gastrointestinal tract. Scientists from the Helmholtz Zentrum München now have shown that many of the adult patients with CF in addition lack a cell surface molecule, which is important for immune defence. The results have been published recently in the 'Journal of Molecular Medicine'.

4 Sep 2014

Ludwig, CRI collaborate with VentiRx to conduct clinical trial with motolimod and immunotherapy agents

The nonprofits Ludwig Cancer Research (Ludwig) and the Cancer Research Institute (CRI) announced today an agreement with VentiRx Pharmaceuticals Inc., a clinical stage biopharmaceutical company, to conduct a clinical trial with motolimod (VTX-2337) combined with other immunotherapy agents available to Ludwig and CRI through other industry partnerships.

4 Sep 2014

Researchers reveal new approaches for antimalarial drug development

Melbourne researchers are making progress towards new antimalarial drugs, after revealing how an antibiotic called emetine blocks the molecular machinery that produces the proteins required for malaria parasite survival.

4 Sep 2014

One-two punch designed to knock out most dangerous brain cancer

University of Michigan Health System doctors have started testing a unique new approach to fighting brain tumors -- one that delivers a one-two punch designed to knock out the most dangerous brain cancer.

3 Sep 2014

Scientists make important breakthrough in fight against debilitating autoimmune diseases

Scientists have made an important breakthrough in the fight against debilitating autoimmune diseases such as multiple sclerosis by revealing how to stop cells attacking healthy body tissue.

3 Sep 2014

Researchers discover pattern of infection of bacterium responsible for causing severe lung infections

Researchers at the University of Liverpool's Institute of Infection and Global Health have discovered the pattern of infection of the bacterium responsible for causing severe lung infections in people with cystic fibrosis.

3 Sep 2014

Clinical studies to treat unmet medical need post-transplantation

A class of biotechnology drugs called monoclonal antibodies is now being tested in clinical studies to treat an unmet medical need post-transplantation, called delayed graft function

3 Sep 2014

Biochemists discover proteins that could lead to better treatments for life-threatening infections

Two Kansas State University biochemists have discovered a family of proteins that could lead to better treatments for Staphylococcus aureus, a pathogenic bacterium that can cause more than 60,000 potentially life-threatening infections each year.

3 Sep 2014

Study suggests phages are sophisticated bacterial predators and can prevent infections

In the battle between our immune systems and cholera bacteria, humans may have an unknown ally in bacteria-killing viruses known as phages.

3 Sep 2014

Researchers identify enzyme that controls spread of breast cancer

Researchers at the University of California, San Diego School of Medicine have identified an enzyme that controls the spread of breast cancer. The findings, reported in the current issue of PNAS, offer hope for the leading cause of breast cancer mortality worldwide.

2 Sep 2014

Amgen seeks EMA approval for marketing talimogene laherparepvec

Amgen today announced the submission of a Marketing Authorization Application (MAA) to the European Medicines Agency (EMA) via the centralized procedure for talimogene laherparepvec seeking approval for the treatment of adults with melanoma that is regionally or distantly metastatic.

2 Sep 2014

Cepheid releases Xpert Flu/RSV XC for accurate determination of Flu A, Flu B and RSV infection

Cepheid announced today the release of Xpert® Flu/RSV XC, an on-demand molecular test for rapid, accurate and reliable determination of Flu A, Flu B, and differentiation of RSV infection.

2 Sep 2014

Researchers find way to take pediatric patient's skin cells

Researchers have found a way to take a pediatric patient's skin cells, reprogram the skin cells to function as heart valvular cells, and then use the cells as part of a tissue-engineered pulmonary valve. A proof of concept study in the September 2014 issue of The Annals of Thoracic Surgery provides more detail on this scientific development.

2 Sep 2014

New vaccine in bid to move away from needles and syringes to skin delivery procedures

Drug delivery technologies that improve access and overall efficacy are becoming an essential part of the entire drug development process.

2 Sep 2014

Risk of obesity higher among adults who had been subjected to abuse as children

Being subjected to abuse during childhood entails a markedly increased risk of developing obesity as an adult.

2 Sep 2014

Researchers identify how Ebola virus dodges the body's antiviral defenses

Researchers at the Washington University School of Medicine have identified one way the Ebola virus dodges the body's antiviral defenses, providing important insight that could lead to new therapies, in research results published in the journal Cell Host & Microbe.

30 Aug 2014

Researchers make surprising discoveries about the body's early responses to HIV infection

Researchers at UC Davis have made some surprising discoveries about the body's initial responses to HIV infection. Studying simian immunodeficiency virus (SIV), the team found that specialized cells in the intestine called Paneth cells are early responders to viral invasion and are the source of gut inflammation by producing a cytokine called interleukin-1 beta (IL-1β).

30 Aug 2014

Immune System News and Research

First Edition: September 4, 2014

Findings may help develop biomarkers to identify HIV patients at risk of dementia

Study investigates whether function of intestines attacked in MS

Scientists aim to develop rapid test system for immune dysfunction to treat cystic fibrosis

Ludwig, CRI collaborate with VentiRx to conduct clinical trial with motolimod and immunotherapy agents

Researchers reveal new approaches for antimalarial drug development

One-two punch designed to knock out most dangerous brain cancer

Scientists make important breakthrough in fight against debilitating autoimmune diseases

Researchers discover pattern of infection of bacterium responsible for causing severe lung infections

Clinical studies to treat unmet medical need post-transplantation

Biochemists discover proteins that could lead to better treatments for life-threatening infections

Study suggests phages are sophisticated bacterial predators and can prevent infections

Researchers identify enzyme that controls spread of breast cancer

Amgen seeks EMA approval for marketing talimogene laherparepvec

Cepheid releases Xpert Flu/RSV XC for accurate determination of Flu A, Flu B and RSV infection

Researchers find way to take pediatric patient's skin cells

New vaccine in bid to move away from needles and syringes to skin delivery procedures

Risk of obesity higher among adults who had been subjected to abuse as children

Researchers identify how Ebola virus dodges the body's antiviral defenses

Researchers make surprising discoveries about the body's early responses to HIV infection

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