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Amycretin delivers unprecedented weight loss in early trial for obesity treatment

Once-weekly amycretin, a novel peptide activating GLP-1, amylin, and calcitonin receptors, produced rapid, substantial, and sustained weight loss in adults with overweight or obesity during a phase 1b/2a trial. The treatment was generally well tolerated, with mostly mild to moderate gastrointestinal side effects, supporting further investigation in larger, longer studies.

23 Jun 2025

Use of sleep heart rate patterns to forecast diabetes risk in pregnancy

This study highlights the potential of heart rate variability as an early indicator of gestational diabetes, facilitating proactive healthcare in pregnancy.

23 Jun 2025

How early-life factors raise lifelong diabetes risks in youth

The surge in diabetes among young people highlights critical gaps in care and the urgent need for comprehensive preventative actions to address this crisis.

19 Jun 2025

Meal and sleep timing play key roles in diabetes prevention

High-resolution digital tracking reveals how daily habits, meal timing, sleep, and physical activity shape metabolic risk for type 2 diabetes. Meal timing, sleep patterns, and activity windows each play distinct roles in insulin resistance and glucose control.

12 Jun 2025

Uncovering the genetic link between type 2 diabetes and brain structure

Type 2 diabetes mellitus (T2DM) is a highly prevalent metabolic disorder worldwide. Beyond glucose dysregulation, it exerts significant effects on the central nervous system.

11 Jun 2025

Real-world study finds lower weight loss with GLP-1 drugs due to early discontinuation

A Cleveland Clinic study shows that semaglutide and tirzepatide – injectable GLP-1 drugs for obesity – produce smaller weight loss in a real-world setting because patients discontinue treatment or use lower maintenance dosages.

10 Jun 2025

Early statin therapy reduces heart attack and stroke risk in diabetes patients

Taking a statin medication is an effective, safe, and low-cost way to lower cholesterol and reduce risk of cardiovascular events.

27 May 2025

Adverse waist-to-height ratio trajectories during childhood linked to early cardiometabolic risk

New research being presented at this year's European Congress on Obesity (ECO) in Malaga, Spain (11-14 May) reveals that adverse waist-to-height ratio trajectories (a marker for central obesity) during childhood may increase cardiometabolic and cardiovascular risk at 10 years old.

11 May 2025

GLP-1 receptor agonists improve mood and metabolic health in adults with mental illness

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) can lead to significant weight loss and improve blood sugar control in adults with severe mental illness, as well as having positive effects on mood, well-being, and quality of life in those both with and without mental illness, according to a systematic review of the available evidence being presented at this year's European Congress on Obesity (ECO) in Malaga, Spain (11-14 May).

11 May 2025

How urine caffeine levels may help detect diabetic eye damage early

Researchers found that higher urinary levels of caffeine and specific metabolites, especially in men, were significantly associated with diabetic retinopathy risk. The cross-sectional study used NHANES 2009–2014 data and highlights potential biomarkers for early detection in diabetic populations.

7 May 2025

Low testosterone linked to higher kidney stone risk in men, study finds

A large cross-sectional study in South Korea found that men with low testosterone levels (below 3.33 ng/mL) were significantly more likely to have kidney stones. This association held even after adjusting for age and metabolic risk factors, suggesting testosterone may play a protective role.

6 May 2025

Black coffee improves insulin sensitivity in women, study finds

Two daily cups of coffee, especially black, are linked to lower insulin resistance and fasting insulin levels in Korean women, suggesting coffee may improve glucose metabolism. The effect was not observed with coffee containing sugar or cream.

4 May 2025

Pecans lower cholesterol and improve diet quality in at-risk adults, study finds

Substituting 57 grams of pecans for usual snacks over 12 weeks improved lipid profiles and diet quality but did not affect vascular function in adults at cardiometabolic risk. A modest weight gain was also observed.

29 Apr 2025

New noninvasive method for early diabetes risk detection

The highs and lows of blood glucose aren't just an energy rollercoaster; they could be a key to detecting diabetes risk early and spare you a needle prick or two.

22 Apr 2025

Only 13% of French adults have optimal heart health, study finds

Researchers assessed the Life’s Essential 8 cardiovascular health (CVH) scores in over 190,000 French adults, revealing that only 13% had optimal CVH. Higher scores were associated with being younger, female, well-educated, and having healthier lifestyle factors.

21 Apr 2025

Brisk walking linked to lower risk of heart rhythm disorders

A brisk walking pace, and the amount of time spent at this speed, may lower the risk of heart rhythm abnormalities, such as atrial fibrillation, tachycardia (rapid heartbeat), and bradycardia (very slow heartbeat), finds research published online in the journal Heart.

16 Apr 2025

Digital lifestyle program cuts diabetes risk by 46% in prediabetics, study of 130k+ adults reveals

A large study of 133,764 adults found that a voluntary digital lifestyle program reduced 10-year diabetes risk by 45.6% in prediabetics and doubled remission rates in diabetics, with significant improvements in triglycerides, insulin resistance, and inflammatory markers like hs-CRP.

14 Apr 2025

Food pantries uncover hidden diabetes crisis in West Chicago

A screening initiative in West Chicago found that 50% of food-insecure individuals had abnormal A1c levels, with many unaware they were diabetic or prediabetic. The findings highlight a critical gap in diagnosis and control among underserved communities.

13 Apr 2025

Vitamin C from fresh foods helps lower heart disease risk in type 2 diabetes

Low vitamin C levels are linked to higher cardiovascular disease prevalence in people with type 2 diabetes. Fresh fruit and vegetable intake is associated with higher vitamin C levels and may offer protective cardiovascular effects.

7 Apr 2025

Study reveals hidden cardiovascular risks in real-world low-carb diets

Researchers examined a real-world low-carbohydrate high-fat (LCHF) diet population to assess links between nutrient intake and cardiovascular risk.

2 Apr 2025