Hypoxia News and Research

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Hypoxia is a condition in which there is a decrease in the oxygen supply to a tissue. In cancer treatment, the level of hypoxia in a tumor may help predict the response of the tumor to the treatment.

Research sheds light on how hypoxia affects T cell function in cancer

Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has plateaued due to therapeutic resistance that renders tumor-infiltrating lymphocytes, or TILs, ineffective.

14 Dec 2024

Potential new mRNA-based therapy for pre-eclampsia

Lipid nanoparticles targeting VEGF mRNA show promise in treating pre-eclampsia, restoring maternal blood pressure and enhancing fetal health in murine models.

13 Dec 2024

Understanding how angiogenesis contributes to drug resistance in breast cancer

Breast cancer, the most common cancer among women, is notorious for its ability to develop resistance to a wide range of treatments, including surgery, chemotherapy, targeted therapies, and immunotherapy.

11 Dec 2024

TCR sequencing sheds light on tumor immune interactions in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) stands as the dominant form of liver cancer, ranking as the fourth leading cause of cancer-related deaths globally.

11 Dec 2024

Targeting intracellular checkpoints to enhance NK cell immunotherapy

Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

27 Nov 2024

Understanding the pathophysiological relationship between OSA and metabolic syndrome

Cardiovascular diseases remain a leading cause of mortality globally, particularly among individuals with both obstructive sleep apnea (OSA) and metabolic syndrome (MetS).

27 Nov 2024

Stress, diet, and vascular health: Can cocoa flavonols help?

Incorporating flavonol-rich foods may counteract stress-induced vascular impairments, offering a dietary strategy for improved cardiovascular health.

19 Nov 2024

Growth hormone-releasing hormone transforms therapeutic potential in health and chronic disease

Researchers review the biological activities of growth hormone-releasing hormone and its analogs.

17 Nov 2024

CAR T cell therapy breakthroughs bring new hope for treating solid tumors

Researchers advance CAR T cell therapy for solid tumors by innovating ways to overcome the unique barriers of solid tumor environments, with promising clinical results.

13 Nov 2024

Asthma associated with memory issues in children

Findings indicate asthma in children correlates with memory issues, suggesting early onset may hinder cognitive growth and executive function development.

13 Nov 2024

Updated recommendations stress importance of CPR for drowning victims

Updated guidance reaffirms the recommendation for cardiopulmonary resuscitation (CPR) and highlights the importance of compressions with rescue breaths as a first step in responding to cardiac arrest following drowning, according to a new, focused update to Special Circumstances Guidelines from the American Heart Association and the American Academy of Pediatrics.

12 Nov 2024

Bloodletting therapy offers promising treatment for heat stroke

Heat stroke is primarily classified into exertional and non-exertional forms. Exertional heat stroke results from strenuous physical activity in high heat, while non-exertional heat stroke typically affects those exposed to extreme heat without engaging in significant physical exertion.

11 Nov 2024

Heat exposure significantly heightens risks for maternal and newborn health

The study reveals that heat exposure increases health risks for pregnant women and their babies, impacting outcomes like preterm birth, low birth weight, and hypertensive disorders.

10 Nov 2024

New insights into the genetic legacy of Denisovans

Scientists believe individuals of the most recently discovered "hominin" group (the Denisovans) that interbred with modern day humans passed on some of their genes via multiple, distinct interbreeding events that helped shape early human history.

8 Nov 2024

Mountaineering mice offer insight into evolutionary adaptation to localized conditions

Teams of mountaineering mice are helping advance understanding into how evolutionary adaptation to localized conditions can enable a single species to thrive across diverse environments.

8 Nov 2024

Sleep apnea raises dementia risk in older women

Researchers determine the differential risk of dementia among men and women based on the presence of obstructive sleep apnea.

6 Nov 2024

New research uncovers 16 genes that aid breast cancer survival

Scientists at the Johns Hopkins Kimmel Cancer Center have identified 16 genes that breast cancer cells use to survive in the bloodstream after they've escaped the low-oxygen regions of a tumor.

5 Nov 2024

Johns Hopkins study offers new hope for wet AMD patients

A new study from researchers at Wilmer Eye Institute, Johns Hopkins Medicine explains not only why some patients with wet age-related macular degeneration (or "wet" AMD) fail to have vision improvement with treatment, but also how an experimental drug could be used with existing wet AMD treatments to save vision.

4 Nov 2024

Unraveling the mechanism of Shufeng Jiedu Capsules in influenza treatment

Shufeng Jiedu Capsules (SFJD), a traditional Chinese medicine preparation, are widely used in the clinical treatment of influenza, yet their mechanism of action remains unclear.

29 Oct 2024

Tibetan women’s high-altitude adaptations drive greater reproductive success

Researchers uncover how specific genetic and cardiovascular traits give Tibetan women an edge in surviving and thriving at high altitudes, linking better oxygen delivery to more successful pregnancies.

23 Oct 2024