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Using contrast-enhanced ultrasound to distinguish hepatic PEComa from HCC without high-risk factors

Announcing a new article publication for BIO Integration journal. Hepatic perivascular epithelioid cell tumor (PEComa) is a rare tumor with malignant potential that is frequently misdiagnosed as hepatocellular carcinoma (HCC), despite requiring distinct treatment approaches.

6 Jan 2026

Study reveals a therapeutic vulnerability in aggressive subtype of triple-negative breast cancer

A new study published today in Science Translational Medicine by researchers at The University of Texas MD Anderson Cancer Center details a therapeutic vulnerability in patients with an aggressive subtype of triple-negative breast cancer.

26 Dec 2025

Combination therapy shows promise to treat a rare, catastrophic pediatric brain cancer

St. Jude Children's Research Hospital scientists identified a promising combination approach to treat a rare, but catastrophic pediatric brain cancer called atypical teratoid rhabdoid tumor (ATRT).

16 Dec 2025

Bifunctional biomaterials for postoperative management of osteosarcoma

Osteosarcoma is the most prevalent primary malignant bone tumor in children and adolescents. The current standard treatment involves a combination of chemotherapy and radical surgical resection.

16 Dec 2025

Indoor tanning loads normal skin with mutations linked to melanoma

Indoor tanning is associated with markedly higher mutation burdens and cancer-driving genetic changes in melanocytes taken from normal-appearing skin, including areas usually protected from sunlight. These molecular alterations provide a biological explanation for the higher odds of melanoma and multiple primary tumors seen in heavy tanning bed users.

15 Dec 2025

New insights into alcohol-related DNA damage and cancer risk

Alcohol consumption leads to the formation of a toxic compound called acetaldehyde, which damages DNA.

15 Dec 2025

AI turns routine pathology slides into powerful maps of the tumor immune landscape

A large study shows that routine H&E pathology slides contain rich spatial proteomic signals that can be decoded by AI to model the tumor immune microenvironment at population scale. By generating virtual multiplex immunofluorescence images, GigaTIME enables pan-cancer discovery of immune patterns linked to invasion stage, survival, and genomic alterations.

10 Dec 2025

Triaptosis could be a promising strategy in the fight against cancer

Cancer remains one of the most critical global public health challenges, exerting profound social, economic, and clinical burdens while limiting gains in human life expectancy.

10 Dec 2025

AI-driven method uncovers genetic interactions that fuel cancer progression

University of South Australia scientists have developed a powerful new way to uncover the genetic interactions that fuel cancer progression, paving the way for earlier and more precise treatments.

9 Dec 2025

Most T-cell/histocyte-rich large B-cell lymphoma patients can safely receive a less toxic treatment

Most patients with a rare and aggressive form of large B-cell lymphoma can safely receive a less toxic treatment than the intensive chemotherapy often used, according to new research from Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine.

8 Dec 2025

A slow-growing, bone-covered, noncancerous mass named as ossifying spindled and epithelioid tumor

It's not often that a pathologist gets to make a diagnosis that works for the patient by preventing treatment from occurring.

8 Dec 2025

Integrating AI into colon cancer diagnosis improves the speed and accuracy of detection

A recent study reveals that integrating Artificial Intelligence (AI) into colon cancer diagnosis over the past five years has significantly improved the speed and accuracy of the detection of the deadly disease.

8 Dec 2025

Lower dose of immunotherapy for malignant melanoma improves results

According to a new study, lower doses of approved immunotherapy for malignant melanoma can give better results against tumors, while reducing side effects.

8 Dec 2025

Study reveals ATM kinase as the key driver of replicative senescence

After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres-the protective caps at the chromosome ends-those caps eventually become too short to prevent chromosome ends from being recognized as DNA breaks.

1 Dec 2025

Triaptosis-based therapeutic innovations could offer renewed hope for cancer patients

Cancer remains one of the most critical global public health challenges, exerting profound social, economic, and clinical burdens while limiting gains in human life expectancy.

1 Dec 2025

Focused ultrasound combined with chemotherapy improves survival in glioblastoma patients

Patients with the deadliest form of brain cancer, glioblastoma, who received MRI-guided focused ultrasound with standard-of-care chemotherapy had a nearly 40 percent increase in overall survival in a landmark trial of 34 patients led by University of Maryland School of Medicine (UMSOM) researchers.

24 Nov 2025

Local anesthetic lidocaine may mitigate pancreatic cancer metastasis

Pinned between the stomach and spine, the pancreas supervises both digestion and blood sugar in the body. It's also the site of an aggressive cancer called pancreatic ductal adenocarcinoma, or PDAC.

13 Nov 2025

LRIG1 could serve as important biomarker to distinguish between glioma types and grades

A new research paper was published in Oncotarget (Volume 16) on November 6, 2025, titled "LRIG1-3 in gliomas: LRIG1 protein expression decreased in higher grade gliomas."

12 Nov 2025

Uppsala researchers develop Trojan horse approach for medulloblastoma treatment

The malignant pediatric brain tumor medulloblastoma is driven by proteins deep within the cancer cells, for which there are often no effective drugs available.

10 Nov 2025

Beta-blockers offer no clinical benefit for myocardial infarction survivors with preserved cardiac function

A major analysis led by the Centro Nacional de Investigaciones Cardiovasculares (CNIC), in collaboration with international institutions, has pooled data from 17,801 myocardial infarction survivors with preserved cardiac function enrolled in five global clinical trials.

10 Nov 2025

Malignant News and Research

Using contrast-enhanced ultrasound to distinguish hepatic PEComa from HCC without high-risk factors

Study reveals a therapeutic vulnerability in aggressive subtype of triple-negative breast cancer

Combination therapy shows promise to treat a rare, catastrophic pediatric brain cancer

Bifunctional biomaterials for postoperative management of osteosarcoma

Indoor tanning loads normal skin with mutations linked to melanoma

New insights into alcohol-related DNA damage and cancer risk

AI turns routine pathology slides into powerful maps of the tumor immune landscape

Triaptosis could be a promising strategy in the fight against cancer

AI-driven method uncovers genetic interactions that fuel cancer progression

Most T-cell/histocyte-rich large B-cell lymphoma patients can safely receive a less toxic treatment

A slow-growing, bone-covered, noncancerous mass named as ossifying spindled and epithelioid tumor

Integrating AI into colon cancer diagnosis improves the speed and accuracy of detection

Lower dose of immunotherapy for malignant melanoma improves results

Study reveals ATM kinase as the key driver of replicative senescence

Triaptosis-based therapeutic innovations could offer renewed hope for cancer patients

Focused ultrasound combined with chemotherapy improves survival in glioblastoma patients

Local anesthetic lidocaine may mitigate pancreatic cancer metastasis

LRIG1 could serve as important biomarker to distinguish between glioma types and grades

Uppsala researchers develop Trojan horse approach for medulloblastoma treatment

Beta-blockers offer no clinical benefit for myocardial infarction survivors with preserved cardiac function

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