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Nuclear binding protein identified as key contributor to trisomy 21-related CHDs

Three copies of chromosome 21 causes Down syndrome (DS), and roughly half of children born each year in the United States with DS-approximately 2,600-also have congenital heart defects (CHDs).

22 Oct 2025

Updated CPR guidelines provide expanded recommendations for managing choking and opioid overdose

The "2025 American Heart Association Guidelines for Cardiopulmonary Resuscitation (CPR) and Emergency Cardiovascular Care (ECC)," published today in the Association's flagship journal, Circulation, marks the first full revision of lifesaving resuscitation guidance since 2020.

22 Oct 2025

Rozanolixizumab prevents congenital heart block in high-risk pregnancy

Congenital heart block, sometimes referred to as cardiac neonatal lupus, is a rare but potentially life-threatening condition that affects babies born to mothers with specific autoantibodies - called anti-SSA/Ro antibodies - which can attack the fetal heart via its electrical conduction system, leading to a slower heart rate.

22 Oct 2025

Immediate skin-to-skin contact offers significant health advantages for infants

Immediate skin-to-skin contact between newborns and their mothers offers a better start in life, improving a number of key health metrics, according to a newly updated Cochrane review.

22 Oct 2025

Prenatal air pollution exposure may slow newborn brain development

The study shows prenatal air pollution exposure correlates with slower brain myelination in infants, emphasizing the need for improved air quality policies.

20 Oct 2025

Maternal exposure to PM2.5 during pregnancy linked to lower myelination in newborns' brains

A study published in Environment International concludes that air pollution during pregnancy is associated with slower brain maturation in newborns.

16 Oct 2025

New breakthrough enables whole genome sequencing in hours

Boston Children's Hospital, along with Broad Clinical Labs and Roche Sequencing Solutions, has demonstrated that rapid genomic sequencing and interpretation are achievable in a matter of hours.

16 Oct 2025

Gene therapy shows long-term success in children with rare immune disorder

Results from the largest cohort of children who received a gene therapy for a rare immunodeficiency condition have shown the long-term safety and efficacy of the curative treatment, in a study led by a UCL researcher.

15 Oct 2025

Maldives achieves historic triple elimination of mother-to-child transmission of diseases

In a landmark public health achievement, the World Health Organization (WHO) has validated the Maldives for eliminating mother-to-child transmission (EMTCT) of hepatitis B, while maintaining its earlier validation (in 2019) for EMTCT of HIV and syphilis.

14 Oct 2025

How genomic screening in newborns found 16 hidden disorders standard tests overlooked

Genomic newborn screening using whole-genome sequencing identified 1.6% of infants with high-chance, treatable genetic conditions, far beyond the capacity of standard biochemical screening. The BabyScreen+ study demonstrated clinical impact, cascade diagnoses, and strong parental acceptance, while highlighting challenges in scalability and equity.

13 Oct 2025

Harvard researchers augment LLM to create expert diagnostic system

Except for one key aspect, the setup is a familiar one in medicine: An expert diagnostician presents a particularly challenging case to a roomful of colleagues, carefully walking them through the patient's symptoms and initial test results.

10 Oct 2025

UCLA scientists uncover the role of DGRs in structuring the infant gut microbiome

Everywhere you go, you carry a population of microbes in your gastrointestinal tract that outnumber the human cells making up your body.

10 Oct 2025

Newborn genomic screening may detect hundreds of additional childhood conditions

Adding genomic sequencing to newborn blood screening would detect hundreds of additional childhood conditions, providing much earlier diagnosis and treatment, according to a new study. A baby's genome, which stays with them for life, could also be re-examined if a health issue arises during their lifetime.

9 Oct 2025

Study links extended breastfeeding to stronger infant immune health

Breastfeeding until at least six months helps babies to fight off infections and reduces chronic inflammation, according to a new study. And better understanding the way specific nutrients in breast milk impact the immune system will improve health outcomes for all infants including those not breastfed.

8 Oct 2025

Depression during pregnancy raises risk of gestational diabetes

Findings indicate that antenatal depression increases the risk of gestational diabetes, underscoring the need for early intervention and lifestyle support.

8 Oct 2025

NIH funds multi-state pilot for genome sequencing in newborn screening

Mass General Brigham and Ariadne Labs, alongside Boston Children's Hospital, Albert Einstein College of Medicine, the Association of Public Health Laboratories (APHL), Case Western Reserve University, Baylor College of Medicine, and sequencing partners GeneDx and Illumina, today announced the launch of BEACONS (Building Evidence and Collaboration for GenOmics in Nationwide Newborn Screening), the nation's first multi-state genomic newborn screening initiative.

2 Oct 2025

Advancing patient safety for children: building safer systems from birth

Laís Junqueira discusses patient safety challenges in pediatric care and the need for system-level innovations to protect children and newborns effectively.

2 Oct 2025

How maternal microbes shape babies’ gut health and disease risk

Early microbial exposures from maternal microbes, milk components, and the environment shape infant gut development and long-term disease risk. The review highlights mechanisms, preventive levers, and research gaps in supporting healthy microbiome inheritance across generations.

29 Sep 2025

Study points toward earlier and more accurate detection of ALS

A new study applying multi-omics techniques and machine learning identified 33 plasma proteins that differ significantly in patients with amyotrophic lateral sclerosis (ALS).

29 Sep 2025