Protein Aggregation News and Research

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Powerful separation technique opens door to characterizing complex samples

Postnova Analytics reports on growing use of its pioneering EAF2000 system to separate and characterize complex proteins, antibodies and viruses as well as charged nanoparticles, colloids and polymers.

From Postnova Analytics 31 May 2019

Uncovering the Structure of HIV Integrase to Inform Drug Discovery

In this interview Dr Kushol Gupta, Research Assistant Professor in the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania talks to News-Medical and Life Sciences about the importance of light scattering techniques for investigating structure and mechanism of action in his ongoing research into HIV integrase and the development of HIV therapeutics.

From Waters | Wyatt Technology 24 Apr 2019

Probing Submicron Protein Aggregation using Asymmetrical Flow Field-Flow Fractionation, AF4, and Light Scattering

The most recent developments by Wyatt in their instrumentation and software have made the full potential of FFF accessible to a wider user base. In this interview, Kim R. Williams and Christoph Johann talk to News-Medical and Life Sciences about the technologies and their research.

From Waters | Wyatt Technology 27 Mar 2019

New method detects potentially disease-causing forms of proteins using fluorescence

A new method uses fluorescence to detect potentially disease-causing forms of proteins as they unravel due to stress or mutations.

14 Feb 2019

RNAs are involved in protein aggregation and neurodegenerative diseases, research reveals

New research reveals RNAs, which are crucial for cells to produce proteins, are also involved in protein aggregation, where proteins do not fold properly and 'clump' together into aggregates. If cells cannot clear these away, they become toxic and prevent cells working properly.

8 Feb 2019

Antibiotic could protect against age-related brain diseases

An antibiotic, minocycline, can increase the lifespan of roundworms by preventing the build-up of proteins during aging, a study in the open-access journal eLife reports.

28 Nov 2018

Researchers find molecule that halts, reverts neurodegeneration caused by Parkinson's disease

The small SynuClean-D molecule interrupts the formation of the alpha-synuclein amyloid fibers responsible for the onset of Parkinson's disease, and reverts the neurodegeneration caused by the disease.

25 Sep 2018

Scientists discover novel mechanism by which synthesized proteins reach target compartment in cell

Proteins are essential constituents of cells and their compartments. Prof. Johannes Herrmann, a researcher at the Technische Universität Kaiserslautern, Germany, and his team discovered a novel mechanism by which newly synthesized proteins reach their respective target compartment in the cell.

17 Sep 2018

Protein aggregation in neurons linked to gene regulation in Huntington's disease

Researchers at Lund University in Sweden have discovered a direct link between the protein aggregation in nerve cells that is typical for neurodegenerative diseases, and the regulation of gene expression in Huntington's disease.

21 Aug 2018

Researchers gain more insight into how FUS protein causes ALS and FTLD

The mutated and aggregated protein FUS is implicated in two neurodegenerative diseases: amyotrophic lateral sclerosis and frontotemporal lobar degeneration.

19 Jul 2018

Mid-infrared biosensor distinguishes multiple analytes in heterogeneous biological samples

Detecting biomolecules, such as lipids, proteins, and nucleic acids and their interactions in heterogeneous biological samples is crucial for understanding a multitude of biological mechanisms in health and disease.

5 Jun 2018

Microglia may play key role in slowing progression of prion diseases, research suggests

Prion diseases are slow degenerative brain diseases that occur in people and various other mammals. No vaccines or treatments are available, and these diseases are almost always fatal. Scientists have found little evidence of a protective immune response to prion infections.

17 May 2018

UC San Diego scientists discover gene that helps prevent neurodegenerative diseases

Scientists know that faulty proteins can cause harmful deposits or "aggregates" in neurological disorders such as Alzheimer's and Parkinson's disease. Although the causes of these protein deposits remain a mystery, it is known that abnormal aggregates can result when cells fail to transmit proper genetic information to proteins.

16 May 2018

Researchers determine cause of difficult-to-control mitochondrial diseases

A Japanese research group has discovered that taurine is conjugated with mitochondrial transfer RNAs (tRNAs), small RNAs that decode genetic information, and that taurine deficiency in tRNA dramatically reduces both mitochondrial protein translation and impairs mitochondrial membrane integrity.

7 Mar 2018

Researchers devise novel approach to develop antibacterial drugs

Researchers at VIB, KU Leuven and UZ Leuven devised a novel approach to develop antibacterial drugs. With antibiotic resistance on the rise worldwide, such new drugs are urgently needed. The Flemish biotech spin-off Aelin Therapeutics will exploit the technology to produce new antibiotics for the clinic.

28 Feb 2018

InSysBio evaluates tau protein phosphorylation related targets for treatment of AD

InSysBio continues to investigate the mechanisms underlying Alzheimer's disease using the quantitative systems pharmacology modeling approach. The part of QSP model describing tau protein was published in the PLOS ONE journal. This is one of more than dozen InSysBio publications in AD area during last seven years.

28 Feb 2018

Protein Aggregation News and Research

Powerful separation technique opens door to characterizing complex samples

Uncovering the Structure of HIV Integrase to Inform Drug Discovery

Probing Submicron Protein Aggregation using Asymmetrical Flow Field-Flow Fractionation, AF4, and Light Scattering

New method detects potentially disease-causing forms of proteins using fluorescence

RNAs are involved in protein aggregation and neurodegenerative diseases, research reveals

Antibiotic could protect against age-related brain diseases

Researchers find molecule that halts, reverts neurodegeneration caused by Parkinson's disease

Scientists discover novel mechanism by which synthesized proteins reach target compartment in cell

Protein aggregation in neurons linked to gene regulation in Huntington's disease

Researchers gain more insight into how FUS protein causes ALS and FTLD

Mid-infrared biosensor distinguishes multiple analytes in heterogeneous biological samples

Microglia may play key role in slowing progression of prion diseases, research suggests

UC San Diego scientists discover gene that helps prevent neurodegenerative diseases

Researchers determine cause of difficult-to-control mitochondrial diseases

Researchers devise novel approach to develop antibacterial drugs

InSysBio evaluates tau protein phosphorylation related targets for treatment of AD

Postnova Analytics to hold second annual seminar on advanced separation techniques

Newly discovered molecular chaperones may soon be part of therapies for Huntington's disease

Malvern Panalytical Announce Efforts Towards a Platform For Protein Aggregation Profiling

New microscope optimized to perform studies using optogenetic techniques

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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