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Most disease-causing mutations that swap amino acids do so by making proteins less stable

Research shows 60% of missense mutations destabilize proteins, linking protein folding to genetic diseases, including cataracts and neurological disorders.

10 Jan 2025

Unraveling the molecular mechanisms of disease-causing mutations

Most mutations which cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a massive study of human protein variants published today in the journal Nature. Unstable proteins are more likely to misfold and degrade, causing them to stop working or accumulate in harmful amounts inside cells.

9 Jan 2025

Scientists uncover key factors for starting autophagy in cells

Recycling takes place in our cells at all times: in a process called autophagy, cell components that are no longer needed are enclosed by membranes and broken down into their basic building blocks.

8 Jan 2025

Breakthrough in immunology: AbMAP’s novel approach to antibody modeling

Researchers developed AbMAP, a cutting-edge framework leveraging transfer learning to model antibody hypervariable regions, significantly improving design and immune repertoire analysis.

2 Jan 2025

Lithocholic acid enhances health and lifespan, mimicking calorie restriction

Lithocholic acid (LCA), a metabolite induced by calorie restriction (CR), activates AMPK and mimics anti-aging benefits. A recent study highlights LCA's role in improving muscle performance, glucose tolerance, and lifespan in aged organisms.

1 Jan 2025

Unexpected discovery opens doors for improved siRNA therapies

In everyday life, when things turn out the opposite of what you expect, it's usually cause for frustration. In science, it's often the starting point for discovery.

20 Dec 2024

Understanding metformin's mechanism in reducing blood sugar

Millions of people take metformin, a Type 2 diabetes medication that lowers blood sugar. The "wonder drug" has also been shown to slow cancer growth, improve COVID outcomes and reduce inflammation. But until now, scientists have been unable to determine how, exactly, the drug works.

18 Dec 2024

Could microalgae fermentation create the superfoods of the future?

Microalgae fermentation unlocks sustainable and nutritious food production, offering bioactive peptides with antidiabetic properties but faces challenges in consumer acceptance.

18 Dec 2024

Nutraceuticals: exploring potential benefits and challenges of an unregulated healthcare frontier

Nutraceuticals offer potential health benefits, from migraine relief to cognitive support, but safety and regulatory issues must be addressed for effective use.

18 Dec 2024

Yeast proteins show promise as natural emulsifiers in daily products

Mention emulsifiers and many people might be unaware what they are used for, but they are present in many daily products, from food to cosmetics.

16 Dec 2024

New discovery reveals twisting action of molecular motors in the DNA

Scientists from the Kavli Institute of Delft University of Technology and the IMP Vienna Biocenter discovered a new property of the molecular motors that shape our chromosomes.

16 Dec 2024

TRiC mutations found to cause developmental brain malformations in children

In 1992, Judith Frydman, PhD, discovered a molecular complex with an essential purpose in all of our cells: folding proteins correctly.

27 Nov 2024

Fungus found in the mouse stomach may hold a key to fungal evolution in the gut

A fungus discovered in the mouse stomach may hold a key to fungal evolution within the gastrointestinal tract, according to new research led by Weill Cornell Medicine investigators.

27 Nov 2024

A toddler got a nasal swab test but left before seeing a doctor. The bill was $445.

Ryan Wettstein Nauman was inconsolable one evening last December. After being put down for bed, the 3-year-old from Peoria, Illinois, just kept crying and crying and crying, and nothing would calm her down.

27 Nov 2024

Protein-based gel offers sustainable solution for personal skincare products

If you have a meticulous skincare routine, you know that personal skincare products (PSCPs) are a big business.

25 Nov 2024

Study reveals the secret to cellular youth may lie in nucleolus size

The secret to cellular youth may depend on keeping the nucleolus—a condensed structure inside the nucleus of a cell—small, according to Weill Cornell Medicine investigators.

25 Nov 2024

Researchers unlock method for mass producing herbal medicine in yeast

Herbal medicine is difficult to produce on an industrial scale. A team of Kobe University bioengineers manipulated the cellular machinery in a species of yeast so that one such molecule can now be produced in a fermenter at unprecedented concentrations.

12 Nov 2024

Greener And Cleaner: Yeast-Green Algae Mix Improves Water Treatment

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8 Nov 2024

Scientists develop first durable human lip cell models in the lab

We use our lips to talk, eat, drink, and breathe; they signal our emotions, health, and aesthetic beauty. It takes a complex structure to perform so many roles, so lip problems can be hard to repair effectively. Basic research is essential to improving these treatments, but until now, models using lip cells - which perform differently to other skin cells - have not been available.

4 Nov 2024

New model sheds light on the genetic roots of polygenic diseases

Many statistical models and algorithms used by scientists can be imagined as a "black box." These models are powerful tools that give accurate predictions, but their internal workings are not easily interpretable or understood.

28 Oct 2024