Antigen News and Research

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An innovative nasal vaccine strategy to combat COVID

In a recent study published in the journal Science, researchers at Yale University developed a novel coronavirus disease 2019 (COVID-19) vaccination strategy termed 'prime and spike' (P&S) that leveraged existing systemic immunity triggered by parenteral vaccination (prime) to boost immunity at the respiratory mucosa.

31 Oct 2022

An estimated 15% of U.S. adults infected with SARS-CoV-2 have long-COVID

In a recent study published in the journal JAMA Network Open, researchers in the United States estimated the sociodemographic factors associated with and prevalence of post-acute coronavirus disease 2019 (COVID-19) symptom sequelae (PASC) or long COVID (LCOVID).

30 Oct 2022

Study reports on a novel property of antibodies, light chain coherence

Researchers investigate whether pairs of unrelated B-cells that have similar heavy chains also have the same light chains.

30 Oct 2022

New insights on antibody response against SARS-CoV-2 Omiron sublineages

Knowing how well vaccination against one SARS-CoV-2 strain (with or without previous infection) counteracts infection with a different strain is a critical research question.

28 Oct 2022

UK Markey Cancer Center earns the rigorous NAPRC accreditation

The University of Kentucky Markey Cancer Center has earned a three-year accreditation from the National Accreditation Program for Rectal Cancer.

28 Oct 2022

The impact of seasonal coronavirus immunity on susceptibility to SARS-CoV-2 infection and COVID-19 vaccination

Researchers investigated whether immunity against seasonal human coronavirus spike proteins of HKU1, OC43, NL63, or 229E could protect against SARS-CoV-2 in vitro.

28 Oct 2022

The epigenetic alterations of monocytes in severe COVID-19

Researchers performed DNA methylation analysis on monocytes in the peripheral blood samples obtained from severe COVID-19 patients.

28 Oct 2022

Scientists computationally restore the potency of an antibody against SARS-CoV-2 Omicron subvariants

A team of researchers from the United States computationally modified the COV2-2130 monoclonal antibody to restore its neutralizing ability against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants, while retaining efficacy against the Delta and wild-type strains.

27 Oct 2022

Combination of multi-specificity and antibody avidity enhances protection against SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, an international team of researchers leveraged the human light chain apoferritin protomer-derived MULTI-specific, multi-Affinity antibody (Multabody, MB) platform for the generation of broad and potent SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2)-neutralizing antibodies (Abs).

27 Oct 2022

Researchers use CRISPR-edited T cells to treat seriously ill children with resistant leukaemia

Researchers at Great Ormond Street Hospital for Children (GOSH) and UCL Great Ormond Street Institute of Child Health (UCL GOS ICH) have used CRISPR/Cas9 technology to engineer donor T cells to try to treat seriously ill children with resistant leukaemia, who had otherwise exhausted all available therapies.

27 Oct 2022

In mild cases of COVID, blood clot risk is higher

Researchers examine the association between COVID-19 and increased cardiovascular outcomes and mortality sequelae.

27 Oct 2022

Increased Gibbs energy of binding indicates greater infectivity of SARS-CoV-2 BA.2.75

Researchers explore the thermodynamic properties of the SARS-CoV-2 Omicron subvariant BA.2.75 to understand its increased transmissibility.

27 Oct 2022

How important is sterilizing immunity in protection against SARS-CoV-2?

The authors discussed the underlying principles of sterilizing immunity and its importance in protecting individuals against SARS-CoV-2 reinfections during the COVID-19 pandemic.

26 Oct 2022

Study uses compartmental modeling to test the efficiency of sentinel surveillance for developing public COVID-19 mitigation policies

Researchers used a stochastic compartmental model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission to examine various sentinel surveillance indicators and determine the minimal sampling effort required for a reliable alert indicating a one-step increase in transmission rate.

26 Oct 2022

$38,398 for a single shot of a very old cancer drug

Dr. Josie Tenore and Paul Hinds were introduced by a mutual friend in 2017 and hadn't been going out long when she laid down the law: He had to get a physical.

26 Oct 2022

New approach to immunotherapy provokes a robust anti-tumor immune response in preclinical models

A new approach to cancer immunotherapy that uses one type of immune cell to kill another - rather than directly attacking the cancer - provokes a robust anti-tumor immune response that shrinks ovarian, lung, and pancreatic tumors in preclinical disease models, according to researchers at the Icahn School of Medicine at Mount Sinai in New York.

25 Oct 2022

Researchers identify specific T cell required to bolster vaccine immunity against fungal pneumonia

Researchers at the University of Illinois College of Veterinary Medicine have demonstrated in a mouse model that a specific type of T cell, one of the body's potent immune defenses, produces cytokines that are necessary for the body to acquire immunity against fungal pathogens.

25 Oct 2022

Applications of artificial intelligence in COVID-19 clinical response measures

Researchers reviewed existing literature on the use of AI in health care, to characterize the AI applications used in clinical applications during the COVID-19 pandemic, investigate the location, timing, and extent of AI use in healthcare, and examine the U.S. regulatory approval processes.

25 Oct 2022

The impact of existing and theoretical mutations on SARS-CoV-2 CD8+ T cell targets

Researchers evaluated the effect of mutations in SARS-CoV-2 variants of concern on CD8+ T cell responses.

25 Oct 2022

Researchers streamline way to manufacture CAR T-cells in just 24 hours

Researchers at University Hospitals (UH) Seidman Cancer Center and a biotech start-up company have developed a streamlined way to manufacture CAR T-cells for immunotherapy treatment in just 24 hours – an improvement over the team's previous benchmark of eight days and commercial suppliers that typically take three weeks.

25 Oct 2022

Antigen News and Research

An innovative nasal vaccine strategy to combat COVID

An estimated 15% of U.S. adults infected with SARS-CoV-2 have long-COVID

Study reports on a novel property of antibodies, light chain coherence

New insights on antibody response against SARS-CoV-2 Omiron sublineages

UK Markey Cancer Center earns the rigorous NAPRC accreditation

The impact of seasonal coronavirus immunity on susceptibility to SARS-CoV-2 infection and COVID-19 vaccination

The epigenetic alterations of monocytes in severe COVID-19

Scientists computationally restore the potency of an antibody against SARS-CoV-2 Omicron subvariants

Combination of multi-specificity and antibody avidity enhances protection against SARS-CoV-2

Researchers use CRISPR-edited T cells to treat seriously ill children with resistant leukaemia

In mild cases of COVID, blood clot risk is higher

Increased Gibbs energy of binding indicates greater infectivity of SARS-CoV-2 BA.2.75

How important is sterilizing immunity in protection against SARS-CoV-2?

Study uses compartmental modeling to test the efficiency of sentinel surveillance for developing public COVID-19 mitigation policies

$38,398 for a single shot of a very old cancer drug

New approach to immunotherapy provokes a robust anti-tumor immune response in preclinical models

Researchers identify specific T cell required to bolster vaccine immunity against fungal pneumonia

Applications of artificial intelligence in COVID-19 clinical response measures

The impact of existing and theoretical mutations on SARS-CoV-2 CD8+ T cell targets

Researchers streamline way to manufacture CAR T-cells in just 24 hours

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