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Trial shows the efficacy of anti-TNF drug for patients with early-stage Dupuytren's disease

Researchers at the Kennedy Institute, University of Oxford, led by Professor Jagdeep Nanchahal have demonstrated the efficacy of the anti-TNF drug adalimumab for patients with early-stage Dupuytren's disease.

30 Apr 2022

Dapagliflozin did not reduce risks in patients hospitalized with COVID-19

In a recent randomized clinical trial of hospitalized patients with COVID-19 and cardio-metabolic risk factors, the sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin did not significantly reduce patients' risk of organ failure, kidney problems, or death compared with placebo, although numerically fewer participants treated with dapagliflozin experienced these outcomes. The findings are published in CJASN.

29 Apr 2022

Study illuminates why cowpea mosaic virus is exceptionally effective against cancer

A plant virus that infects legumes, called cowpea mosaic virus, has a special power that you may not have known about: when injected into a tumor, it triggers the immune system to treat the cancer - even metastatic cancer - and prevents it from recurring.

27 Apr 2022

CRISPR/Cas9 deletions induce adverse on-target genomic effects

Researchers utilized a CRISPR/Cas9 system to evaluate the usage of tRNA by deleting two tRNA genes from the genomes of hyper hepatocellular carcinoma and human near-haploid chronic myeloid leukemia cells.

27 Apr 2022

Highly Effective Single-Dose HPV Vaccination for the Eradication of Cervical Cancer

In this interview, News-Medical speaks to Dr. Ruanne Barnabas about the KEN She study which found that a single-dose Human Papillomavirus (HPV) vaccination was effective in preventing incident persistent oncogenic HPV infection.

27 Apr 2022

Johns Hopkins scientists receive $7.8 million funding from Break Through Cancer

The Johns Hopkins Kimmel Cancer Center and the Departments of Gynecology/Obstetrics, Neurosurgery and Pathology have been awarded more than $7.8 million for novel, multicenter projects designed to intercept and find cures for several deadly cancers, including pancreatic cancer, ovarian cancer, and the brain cancer known as glioblastoma.

26 Apr 2022

Study uncovers the regulator of cancer ‘stemness’

The protein FOXK2 promotes survival of cancer stem cells in ovarian cancer, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.

26 Apr 2022

Genetic variations in critical mitochondrial enzyme play a role in age-related mobility changes

Age-related changes in strength and mobility may depend on genetic variations in a critical mitochondrial enzyme, suggests a study published today in eLife.

26 Apr 2022

World Malaria Day 2022: How the knockdown of P. falciparum RAP01 and RAP21 proteins could lead to novel antimalarial therapeutics

As part of World Malaria Day 2022, we interview Karine Le Roch PH.D., about her latest research into how novel antimalarial therapeutic strategies could be on the horizon, after identifying two proteins that are critical to the survival of the malaria parasite, Plasmodium falciparum.

25 Apr 2022

Marine resources could be promising drug candidates against SARS-CoV-2 Omicron

A recent review paper, published in the MDPI’s specialized journal COVID, highlights key features of the Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – and examines the potential and roadblocks in using renewable marine resources in the fight against the coronavirus disease 2019 (COVID-19).

24 Apr 2022

Rice educates future leaders in nano-enabled cancer applications

Nanotechnology is increasingly important to the development of treatments for cancer. But to succeed, clinicians need to understand it.

22 Apr 2022

RNA splicing abnormalities in COVID-19 patients

This study entailed the integration of multiple-omics datasets to examine the dysregulation in the host splicing mechanism and alteration in protein isoforms among COVID-19 patients.

20 Apr 2022

Scientists receive $4.6 million for a program that matches mental health patients with psychotherapists

A University of Massachusetts Amherst psychologist has received a $4.6 million funding award from the Patient-Centered Outcomes Research Institute (PCORI) to implement a program that matches mental health patients with psychotherapists based on the therapist's previously established effectiveness strengths.

20 Apr 2022

Scientists create a bioengineered 3D model that mimics the biology of two rare neuromuscular diseases

A scientific team supported by the National Institutes of Health has created a tiny, bioengineered 3-D model that mimics the biology of chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy, a pair of rare, devastating neuromuscular diseases.

19 Apr 2022

Scientists precisely define the ‘identity card’ of pancreatic endocrine cells

The pancreas is a key metabolic regulator. When pancreatic beta cells cease producing enough insulin, blood sugar levels rise dangerously — a phenomenon known as hyperglycemia — thus triggering diabetes.

19 Apr 2022

Healthcare disparities are exacerbated among rural, transgender populations, study shows

It's already well-documented that West Virginians in rural pockets of the state face limitations to accessible and quality healthcare. For members of the transgender and gender diverse populations, those disparities are exacerbated, according to West Virginia University research.

18 Apr 2022

Translation News and Research

Trial shows the efficacy of anti-TNF drug for patients with early-stage Dupuytren's disease

Dapagliflozin did not reduce risks in patients hospitalized with COVID-19

Study illuminates why cowpea mosaic virus is exceptionally effective against cancer

CRISPR/Cas9 deletions induce adverse on-target genomic effects

Highly Effective Single-Dose HPV Vaccination for the Eradication of Cervical Cancer

Johns Hopkins scientists receive $7.8 million funding from Break Through Cancer

Study uncovers the regulator of cancer ‘stemness’

Genetic variations in critical mitochondrial enzyme play a role in age-related mobility changes

World Malaria Day 2022: How the knockdown of P. falciparum RAP01 and RAP21 proteins could lead to novel antimalarial therapeutics

Marine resources could be promising drug candidates against SARS-CoV-2 Omicron

Rice educates future leaders in nano-enabled cancer applications

RNA splicing abnormalities in COVID-19 patients

Scientists receive $4.6 million for a program that matches mental health patients with psychotherapists

Scientists create a bioengineered 3D model that mimics the biology of two rare neuromuscular diseases

Scientists precisely define the ‘identity card’ of pancreatic endocrine cells

Healthcare disparities are exacerbated among rural, transgender populations, study shows

Study predicts that different statins exhibit divergent effects on host response to SARS-CoV-2 infection

A comprehensive rule book for the design of safe and efficient therapeutic cells

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Quantum computing to predict RNA secondary structures

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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