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Natural product with grape seed extracts, lactic acid, and pea protein could effectively manage bacterial vaginosis

Researchers evaluate the efficacy of using a product comprising lactic acid, grape seed extract, and pea protein in managing bacterial vaginosis in vivo.

28 Feb 2023

What is the effect of maternal circulating amino acids on offspring birthweight?

Researchers examined the effect of serum levels of 20 amino acids in a mother during pregnancy on offspring birthweight in a two-sample summary data Mendelian randomization framework.

27 Feb 2023

Experts develop commercial formulation Campto for colorectal cancer

Announcing a new publication for Acta Materia Medica journal. The compound 7-ethyl-10-hydroxy-camptothecin (SN38) is a broad-spectrum antitumor agent whose applications are greatly limited by its poor solubility. Therefore, irinotecan, the hydrophilic derived prodrug of SN38, has been developed as the commercial formulation Campto® for colorectal cancer.

25 Feb 2023

Study findings likely to guide the design of engineered TAPBPR variants with tailored HLA specificity

Researchers at Children's Hospital of Philadelphia (CHOP) have identified variants of a chaperone molecule that optimizes the binding and presentation of foreign antigens across the human population, which could open the door to numerous applications where robust presentation to the immune system is important, including cell therapy and immunization. The findings were published today in Science Advances.

24 Feb 2023

Researchers successfully grow electrodes in living tissues

The boundaries between biology and technology are becoming blurred. Researchers at Linköping, Lund, and Gothenburg universities in Sweden have successfully grown electrodes in living tissue using the body's molecules as triggers.

24 Feb 2023

Fixation Before Dissociation Using a Deep Eutectic Solvent Preserves In Vivo States and Phospho-Signalling in Single-Cell Sequencing Presented

Researchers at the University of Alabama at Birmingham have demonstrated a novel way of fixing cells and preserving their biomolecules prior to single cell dissociation without the need for harsh enzymatic/mechanical approaches.

From Rapid Labs Ltd 24 Feb 2023

NQO2 gene as a novel potential target in Parkinson’s disease

A new study under review at the journal Scientific Reports and currently available on the Research Square* preprint server aimed to analyze the toxic effects of 6OHDA along with a related role of NQO2 in murine and human astrocytes.

23 Feb 2023

New prototype treatment proves effective against the venom of African and Asian elapid snakes

Prototype treatment for snake bite envenoming proves effective against the venom of African and Asian elapid snakes, such as some cobra, mamba, and krait species, new research shows.

23 Feb 2023

Researchers report the circulation of a novel MERS-like coronavirus in Malayan pangolins

Researchers reported the circulation of a novel MERS-like coronavirus among Malayan pangolins, Manis javanica HKU4-associated CoV (MjHKU4r-CoV).

21 Feb 2023

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Researchers presented eight hallmarks of neurodegenerative diseases (NDDs), their in vivo biomarkers, and interactions to help categorize NDDs and specify patients within a specific NDD.

21 Feb 2023

Propylene glycol prevents airborne transmission of respiratory viruses

Researchers assess the ability of propylene glycol to inactivate infection caused by respiratory viruses and prevent airborne transmission.

20 Feb 2023

Genome editing prevents hypertrophic cardiomyopathy in mice

In a recent study published in the journal PLoS Digital Health, researchers pursued one-time cures for hypertrophic cardiomyopathy (HCM). They used a previously constructed murine model of HCM, designated as R403Q-129SvEv, to evaluate two different genetic therapies, as follows:

19 Feb 2023

Research reports full efficacy of Sotrovimab against BQ.1.1 viral replication in a non-human primate challenge model

Researchers used a non-human primate model to show that Sotrovimab, a commercial mAb also known as Xevudy, was fully effective against SARS-CoV-2 Omicron BA.5 sub-lineage and its derivatives, such as BQ.1.1.

17 Feb 2023

An oral and on-demand male contraceptive

Researchers identify a soluble adenylyl cyclase (sAC) inhibitor that has the potential to be used as an on-demand oral contraceptive for men.

16 Feb 2023

Penn engineers address the longstanding gap in reproductive health care with targeted RNA therapy

Pre-eclampsia is a leading cause of stillbirths and prematurity worldwide, occurring in 3 – 8 % of pregnancies. A disorder characterized by high maternal blood pressure, it results from insufficient vasodilation in the placenta, restricting blood flow from the mother to the fetus.

16 Feb 2023

Inventia Life Science collaborates with MSD to develop 3D advanced cell models for neurodegenerative disease drug discovery

Inventia Life Science, a world leader in advanced cell models for biomedical research and drug discovery, today announced a collaboration with MSD (tradename of Merck & Co., Inc., Rahway, N.J., USA) using Inventia’s RASTRUM™ 3D cell culture platform.

From Inventia Life Science 16 Feb 2023

in vivo News and Research

Natural product with grape seed extracts, lactic acid, and pea protein could effectively manage bacterial vaginosis

What is the effect of maternal circulating amino acids on offspring birthweight?

Experts develop commercial formulation Campto for colorectal cancer

Study findings likely to guide the design of engineered TAPBPR variants with tailored HLA specificity

Researchers successfully grow electrodes in living tissues

Fixation Before Dissociation Using a Deep Eutectic Solvent Preserves In Vivo States and Phospho-Signalling in Single-Cell Sequencing Presented

NQO2 gene as a novel potential target in Parkinson’s disease

New prototype treatment proves effective against the venom of African and Asian elapid snakes

Researchers report the circulation of a novel MERS-like coronavirus in Malayan pangolins

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Propylene glycol prevents airborne transmission of respiratory viruses

Genome editing prevents hypertrophic cardiomyopathy in mice

Research reports full efficacy of Sotrovimab against BQ.1.1 viral replication in a non-human primate challenge model

An oral and on-demand male contraceptive

Penn engineers address the longstanding gap in reproductive health care with targeted RNA therapy

Inventia Life Science collaborates with MSD to develop 3D advanced cell models for neurodegenerative disease drug discovery

Jamaican fruit bat's response to SARS-CoV-2 adapted to human

Protein degradation approach can be used to hit an ‘undruggable’ target against cancer

Novel predictive index for gastric cancer prognosis

Active compound in Lion’s Mane mushroom improves nerve growth and memory

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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