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Evolution of Antibiotic Tolerance Promotes Resistance to Combination Regimens

A new study suggests that the evolution of antibiotic tolerance requires further investigation if newly designed antibiotic treatments are going to be able to prevent drug-resistant infections.

10 Jan 2020

New molecular probe senses the state of proteome in live cells

The folding state of the proteins in live cells often reflect the cell’s general health. Australian scientists have developed a molecular probe that senses the state of the proteome—the entire set of the proteins—by measuring the polarity of the protein environment.

10 Jan 2020

Scientists secure funding to develop better methods for evaluation of topically applied drugs

A team of leading scientists from Bath University UK, the UK's National Physical Laboratory, and the Colorado School of Mines USA has secured funding from the US Food and Drug Administration to develop better methods to assess the performance of topically applied drug products.

10 Jan 2020

Family doctors in rural America tackle crisis of addiction and pain

Dr. Angela Gatzke-Plamann didn’t fully grasp her community’s opioid crisis until one desperate patient called on a Friday afternoon in 2016.

10 Jan 2020

Siah2 Gene Control could Help Treat Melanomas More Effectively

To develop improved cancer immunotherapies, it is essential to understand how cancers shut down the natural immune response to foreign antigens. This current study demonstrates how mice lacking the Siah2 gene, fail to develop BRAF-mutation carrying melanoma from the corresponding cells, completely rejecting them. This could help in boosting the anticancer effect of existing specific immune checkpoint inhibitors, such as anti-PD-1 drugs.

10 Jan 2020

Rejuvenating the BCG Vaccine

A new primate study published in the journal Nature in January 2020, reports that the almost century-old BCG vaccine against tuberculosis, may be used differently to achieve better protection against lung tuberculosis. While more work remains to be carried out before the findings can be accepted as the basis for clinical practice, they are extremely promising in the fight against this killer.

10 Jan 2020

Researchers develop new approach to better understand protein interaction in the body

Proteins are often called the working molecules of the human body. A typical body has more than 20,000 different types of proteins, each of which are involved in many functions essential to human life.

10 Jan 2020

21-gene recurrence score can aid in radiation decision-making, shows study

A new study shows that a test physicians commonly used to guide chemotherapy treatment for post-breast cancer surgery patients may also help them decide whether radiation therapy may be of benefit.

10 Jan 2020

Integral Molecular announces panel of P2X7 antibodies for autoimmune disorders

Integral Molecular, the leader in discovering antibodies against multipass membrane proteins, announces lead monoclonal antibodies (MAbs) against P2X7, a structurally complex ion channel that is the target for autoimmune disorders including atopic dermatitis and glomerulonephritis.

10 Jan 2020

Harnessing biology and technology to develop much-needed treatments for depression

New research into the biology of depression, along with new and evolving technologies, provides the basis for developing the next generation of treatments for major depressive disorder, according to the special January/February issue of Harvard Review of Psychiatry.

9 Jan 2020

Common genetic defect in prostate cancer associated with worse prognosis

Like security screening to make sure nothing harmful makes its way into a crowded area, cells in the human body use checkpoints to control their growth and prevent harmful mutations from making their way into new cell populations and causing trouble.

9 Jan 2020

Nano-sized copper compounds together with immunotherapy can kill cancer cells

An interdisciplinary team of scientists from KU Leuven, the University of Bremen, the Leibniz Institute of Materials Engineering, and the University of Ioannina has succeeded in killing tumour cells in mice using nano-sized copper compounds together with immunotherapy. After the therapy, the cancer did not return.

9 Jan 2020

New method uses MRI, machine learning to forecast genetic mutations in glioma tumors

Researchers at Osaka University have developed a computer method that uses magnetic resonance imaging (MRI) and machine learning to rapidly forecast genetic mutations in glioma tumors, which occur in the brain or spine. The work may help glioma patients to receive more suitable treatment faster, giving better outcomes.

9 Jan 2020

Administering enzalutamide results in significant increase in PSMA density on tumor surface

When a non-scientist tries to imagine a scientist, the image that often arises is one of a somewhat remote, rather idealistic genius sitting alone in their room or laboratory and somehow discovering the most amazing things without every having contact with the 'normal' world.

9 Jan 2020

First patient recruited for UK-wide Parkinson's disease trial

The first patient has been recruited for a UK-wide trial into tackling one of the most disabling complications of Parkinson's disease, led by the Royal United Hospitals Bath NHS Foundation Trust and the University of Bristol.

9 Jan 2020

Smoking dormant HIV virus out into the open to develop a cure

Ever since antiretroviral treatments against HIV infection were introduced in 1996, scientists have eagerly been hunting for a cure for the disease.

9 Jan 2020

Scientists discover how bacterial evolution of antibiotic arsenals is providing new drug blueprints

Scientists from Trinity College Dublin have discovered that two very different species of bacteria have evolved distinct, powerful antibiotic arsenals for use in the war against their bacterial neighbors.

9 Jan 2020

Research reveals cardiac thin filament structure and function

Researchers at Osaka University used electron cryomicroscopy to image essential cardiac muscle components, known as thin filaments, with unprecedented resolution.

9 Jan 2020

House Energy and Commerce Committee scheduled to hold hearing on immunosuppressive drug coverage

The House Energy and Commerce Committee is scheduled to hold a hearing on Wednesday, January 8, on the Comprehensive Immunosuppressive Drug Coverage for Kidney Transplant Patients Act of 2019, advancing a long-standing legislative priority of the American Society of Nephrology.

9 Jan 2020

ToxPoint article highlights alternative mechanism to bring focus to major issues in toxicology

The new year has brought with it advances to the Society of Toxicology's official journal, Toxicological Sciences, some of which are reflected in the January 2020 issue - Volume 173, Issue 1.

9 Jan 2020

Drugs News and Research

Evolution of Antibiotic Tolerance Promotes Resistance to Combination Regimens

New molecular probe senses the state of proteome in live cells

Scientists secure funding to develop better methods for evaluation of topically applied drugs

Family doctors in rural America tackle crisis of addiction and pain

Siah2 Gene Control could Help Treat Melanomas More Effectively

Rejuvenating the BCG Vaccine

Researchers develop new approach to better understand protein interaction in the body

21-gene recurrence score can aid in radiation decision-making, shows study

Integral Molecular announces panel of P2X7 antibodies for autoimmune disorders

Harnessing biology and technology to develop much-needed treatments for depression

Common genetic defect in prostate cancer associated with worse prognosis

Nano-sized copper compounds together with immunotherapy can kill cancer cells

New method uses MRI, machine learning to forecast genetic mutations in glioma tumors

Administering enzalutamide results in significant increase in PSMA density on tumor surface

First patient recruited for UK-wide Parkinson's disease trial

Smoking dormant HIV virus out into the open to develop a cure

Scientists discover how bacterial evolution of antibiotic arsenals is providing new drug blueprints

Research reveals cardiac thin filament structure and function

House Energy and Commerce Committee scheduled to hold hearing on immunosuppressive drug coverage

ToxPoint article highlights alternative mechanism to bring focus to major issues in toxicology

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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