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Research identifies super-enhancers as novel target for pancreatic ductal adenocarcinoma

Differential H3K27AC marks were identified at enhancer regions of genes including c-MYC, MED1, OCT-4, NANOG, and SOX2 that can act as super-enhancers (SE), cluster of genes in non-cancerous, cancerous and metastatic PDAC cell lines.

1 Mar 2019

Protein content of tumors correlates with treatment response and survival in glioma patients

Brain tumors vary widely in how they respond to treatment. However, early assessment of therapy response is essential in order to choose the best possible treatment for the patient.

28 Feb 2019

Fusion of mitochondria enables cells to more efficiently use oxygen for energy

Mitochondria are the powerhouses of the cell. And for mitochondria, much like for double-header engines stacked together in a steam train, working in multiples has its benefits.

27 Feb 2019

Lack of diversity in cell lines does not allow minorities to reap the benefits of precision medicine

As the biomedical field races to develop therapies based on an individual's genetic makeup, a City of Hope scientist and his colleagues found that some commercial cell lines used for countless laboratory studies have mislabeled ancestry when it comes to minorities.

25 Feb 2019

Study shows link between ACA Medicaid expansion and impact of colon cancer on Kentuckians

A new University of Kentucky study published in the Journal of the American College of Surgeons shows a direct link between the adoption of the Affordable Care Act (ACA) Medicaid expansion and the impact of colon cancer on Kentuckians.

25 Feb 2019

New study finds how high-fat diets fuel colorectal cancer growth

As cancer death rates drop overall, doctors have noted a frightening anomaly: deaths from colorectal cancer in people under 55 appear to be creeping up. According to the American Cancer Society, deaths in this younger group increased by 1 percent between 2007 and 2016.

22 Feb 2019

New forms of older anti-cancer agent appear to enhance immune response to fight melanoma

Researchers at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins and the Johns Hopkins University School of Medicine report two new forms of an older anti-cancer agent they developed appear to enhance the immune system's ability to fight melanoma in mice.

20 Feb 2019

Smoking may blight immune response against melanoma and reduce survival

Melanoma patients with a history of smoking cigarettes are 40 per cent less likely to survive their skin cancer than people who have never smoked, according to a new report funded by Cancer Research UK.

18 Feb 2019

Immune checkpoint molecule protects against future development of cancer

A research team at the University of Louisville has discovered that an immune checkpoint molecule they developed for cancer immunotherapy, also protects against future development of multiple types of cancer when administered by itself.

15 Feb 2019

Suspicious spots on the lungs of children with rhabdomyosarcoma do not behave like metastases

Rhabdomyosarcoma is a malignant soft tissue tumor in the muscle tissue of children and adolescents. About 20 children are diagnosed with rhabdomyosarcoma per year in the Netherlands. "Metastases in these children are often found in the lungs," says professor Hans Merks of the Princess Máxima Center for Pediatric Oncology, who led the study.

15 Feb 2019

Novel approach uses small amounts of tissue to quantify PD-L1 expression levels in tumors

Immune checkpoint inhibitors, such as the anti-PD-1 antibody pembrolizumab, have become important tools for managing non-small-cell lung cancer.

14 Feb 2019

New machine learning method predicts if atypical ductal hyperplasia will turn cancerous

Atypical ductal hyperplasia is a breast lesion associated with a four- to five-fold increase in the risk of breast cancer.

13 Feb 2019

Study discovers new therapy for aggressive blood cancer

Acute myeloid leukemia is the most common form of acute leukemia. It is characterized by an increase of malignant myeloid progenitor cells at the expense of mature blood cells.

13 Feb 2019

Researchers provide insight into how breast tissue stiffening promotes cancer development

A study provides new insight into how the stiffening of breast tissue plays a role in breast cancer development. By examining how mammary cells respond in a stiffness-changing hydrogel, bioengineers at the University of California San Diego discovered that several pathways work together to promote the transformation of breast cells into cancer cells.

13 Feb 2019

Researchers discover new therapeutic target for rare, aggressive pediatric cancers

Researchers at The University of Texas MD Anderson Cancer Center have discovered that malignant rhabdoid tumors, a rare pediatric cancer without effective treatments, may be sensitive to drugs that block the cancer cell's ability to dispose of misfolded proteins.

12 Feb 2019

Immunotherapy drug can be effective in treating patients with recurrent brain tumors

A UCLA-led study suggests that for people with recurrent glioblastoma, administering an immunotherapy drug before surgery is more effective than using the drug afterward.

11 Feb 2019

Increase in vocal-cord cancers among young adults appears to be the result of HPV infection

A remarkable recent increase in the diagnosis of vocal-cord cancer in young adults appears to be the result of infection with strains of human papilloma virus that also cause cervical cancer and other malignancies.

8 Feb 2019

New DNA-based nanomachines can be used for gene therapy of cancer

Scientists from ITMO in collaboration with their international colleagues proposed new DNA-based nanomachines that can be used for gene therapy of cancer.

8 Feb 2019

Immunotherapy drug found to be effective in patients with advanced Merkel cell carcinoma

A multi-center phase II clinical trial investigating pembrolizumab as a first-line and programmed cell death-1 therapy in patients with advanced Merkel cell carcinoma reports lasting tumor control, generally manageable side effects and improved overall survival.

8 Feb 2019

New prostate cancer prediction tool has unmatched accuracy

A team of researchers from the Icahn School of Medicine at Mount Sinai and Keck School of Medicine at the University of Southern California have developed a novel machine-learning framework that distinguishes between low- and high-risk prostate cancer with more precision than ever before.

7 Feb 2019

Malignant News and Research

Research identifies super-enhancers as novel target for pancreatic ductal adenocarcinoma

Protein content of tumors correlates with treatment response and survival in glioma patients

Fusion of mitochondria enables cells to more efficiently use oxygen for energy

Lack of diversity in cell lines does not allow minorities to reap the benefits of precision medicine

Study shows link between ACA Medicaid expansion and impact of colon cancer on Kentuckians

New study finds how high-fat diets fuel colorectal cancer growth

New forms of older anti-cancer agent appear to enhance immune response to fight melanoma

Smoking may blight immune response against melanoma and reduce survival

Immune checkpoint molecule protects against future development of cancer

Suspicious spots on the lungs of children with rhabdomyosarcoma do not behave like metastases

Novel approach uses small amounts of tissue to quantify PD-L1 expression levels in tumors

New machine learning method predicts if atypical ductal hyperplasia will turn cancerous

Study discovers new therapy for aggressive blood cancer

Researchers provide insight into how breast tissue stiffening promotes cancer development

Researchers discover new therapeutic target for rare, aggressive pediatric cancers

Immunotherapy drug can be effective in treating patients with recurrent brain tumors

Increase in vocal-cord cancers among young adults appears to be the result of HPV infection

New DNA-based nanomachines can be used for gene therapy of cancer

Immunotherapy drug found to be effective in patients with advanced Merkel cell carcinoma

New prostate cancer prediction tool has unmatched accuracy

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