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Key target for Foot-and-Mouth drug revealed

A complete picture of Foot-and-Mouth Disease's key replication enzyme could lead to the development of new drugs to control the disease without recourse to vaccination or slaughter, scientists report today.

21 Mar 2005

Lack of sleep activates the body’s defence mechanisms

A lack of sleep is considered a threat situation, which activates the body’s defence mechanisms. This is the same type of response that protects the body against viruses and bacteria as well as in stress situations.

16 Mar 2005

Aspirin use appears to reduce the incidence of colon polyps

The association between regular aspirin use and a reduced risk of precancerous colon polyps may be strongest in those with particular genetic variants.

15 Mar 2005

Selenium, vitamin E and the tomato nutrient lycopene have been shown to reduce prostate cancer

Greater levels of selenium, vitamin E and the tomato nutrient lycopene have been shown to reduce prostate cancer in one out of every four Caucasian males - those who inherit a specific genetic variation that's particularly sensitive to oxidative stress.

15 Mar 2005

Drug therapy may be comparable to invasive cardiac procedures for elderly patients with heart attack

Although the type and intensity of treatment for acute myocardial infarction (AMI) [heart attack] varies widely across the country, elderly patients who receive intensive medical treatment may have comparable survival as those who undergo invasive cardiac procedures (such as angioplasty and bypass surgery), according to a study in the March 16 issue of JAMA.

15 Mar 2005

Brewing up potential anti-cancer drugs from green tea

Drinking green tea has a protective effect against some forms of cancer but drinking large amounts can increase the risk of birth defects such as spina bifida – according to previous epidemiological studies.

15 Mar 2005

Neuronal death and processing of Tau protein in Alzheimer’s Disease (AD)

In a research report recently published in the Journal of Alzheimer's Disease, published by IOS Press, a research group from the International School for Advanced Studies (ISAS\SISSA) in Trieste (Luisa Fasulo, Gabriele Ugolini e Antonino Cattaneo) showed that a processed form of tau protein induces neuronal death by apoptosis (programmed cell death) when expressed in cultured rat hippocampal neurons.

15 Mar 2005

New insight into key mechanism by which cells limit cholesterol

The finding suggests a novel approach to the development of cholesterol-lowering drugs that may boost the effect of statins, one of the most prescribed cholesterol inhibitors, according to researchers at the University of Texas Southwestern Medical Center.

15 Mar 2005

Blacks less likely to get expensive, newer heart treatments

Blacks who suffer the most common type of cardiac ischemia – non-ST-elevation acute coronary syndrome – are less likely than whites to receive expensive or newer evidence-based treatments, according to a report in a special disparities themed issue of Circulation: Journal of the American Heart Association.

15 Mar 2005

Novel Australian anti-cancer therapy has begun safety testing in human subjects

An international medical conference here heard that an Australian developed anti-cancer therapy based on the use of a common cold virus to control cancer cell growth has begun safety testing in human subjects.

15 Mar 2005

Researchers identify biochemical target that could lead to a new class of antibiotics to fight TB

A worldwide health problem, tuberculosis kills more people than any other bacterial infection. The World Health Organization estimates that two billion people are infected with TB, and that two million people die each year from the disease.

14 Mar 2005

Discovery may provide a new target to treat sepsis

Part of the immune system's pro-inflammatory response to bacterial invasion is to increase nitric oxide levels with an enzyme called inducible nitric oxide synthase.

14 Mar 2005

DNA weak links may provide clues to cancer biology

The chromosomes of mammals, including humans, contain regions that are particularly prone to breaking under conditions of stress and in cancer. Now, new research by geneticists at Duke University Medical Center finds that yeast cells also contain such weak links in DNA and begins to reveal the molecular characteristics of these links that might help to explain them.

13 Mar 2005

RNA interference as promising therapy for ALS

Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland have used RNA interference in transgenic mice to silence a mutated gene that causes inherited cases of amytrophic lateral sclerosis (ALS), substantially delaying both the onset and the progression rate of the fatal motor neuron disease.

13 Mar 2005

Active brains stave off Alzheimer's signs

Mice who keep busy playing with toys also keep their brains and bodies active; more importantly, they also have lower levels of the peptides and brain plaques associated with Alzheimer's disease, compared to mice raised in environments not "enriched" with chew toys, running wheels,and tunnels, according to a new study in the 11 March issue of the journal Cell.

13 Mar 2005

Telomerase finding has major implications for cancer

UCLA biochemists have determined the three-dimensional structure of a major domain of telomerase, the enzyme that helps maintain telomeres - small pieces of DNA on the ends of chromosomes that act as protective caps - allowing DNA ends to be copied completely when cells are replicated.

9 Mar 2005

Finding may open new horizons for understanding the initiation of chemically induced cancers

A team from the chemistry and biology departments of New York University, in collaboration with Memorial Sloan Kettering Cancer Center (MSKCC), has uncovered a conformational switch - a change in shape in a carcinogen-damaged DNA site - in tumor suppressor genes altered by a known cancer-causing chemical found in cigarette smoke.

9 Mar 2005

Lipitor patients who reduced 'bad' cholesterol show decrease in heart attack and stroke

Patients with coronary heart disease who took Pfizer's cholesterol-lowering medicine Lipitor (atorvastatin calcium) and lowered their cholesterol to well below recommended levels experienced significantly fewer heart attacks and strokes than those who only lowered their cholesterol to recommended levels

8 Mar 2005

Study finds potential link to help find blocked heart arteries

A blood test in combination with a stress test can help better determine if someone is likely to have a blocked heart artery, according to a study by doctors at Providence Hospital in Southfield, Mich.

8 Mar 2005

Blood pressure treatment could cut risk of strokes and heart attacks

A new treatment strategy for hypertension can cut the risk of strokes by around 25 percent and coronary events by around 15 percent according to the preliminary results of a major international trial announced at the American College of Cardiology Late Breaking Clinical Trials II Meeting in Orlando today.

8 Mar 2005