Protein C News and Research

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Anti-diabetic drug could be repurposed for treating Parkinson's disease

A hallmark of Parkinson's disease is the degeneration of a group of dopaminergic neurons in the brain, which play key roles in movement initiation and co-ordination.

24 Nov 2020

Scoring system can help improve the diagnosis of concomitant heart diseases

Aortic stenosis is one of the most common heart valve defects. Its prevalence increases with age and it often requires treatment.

24 Nov 2020

The role of micro-RNA in SARS-CoV-2 infection and COVID-19

A team of researchers based in Iran have explored the role of micro-RNA in COVID-19. Their study titled, “The emerging role of microRNAs in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection,” was published in the latest issue of the journal International Immunopharmacology.

24 Nov 2020

Scientists show SARS-CoV-2's viral replication with 3D integrative imaging

A team of researchers at Heidelberg University in Germany have performed a detailed imaging analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to determine how the virus reprograms infected cells.

24 Nov 2020

Aprotinin inhibits SARS-CoV-2 entry and replication in cells cultures

Researchers at the University of Kent in the UK and the Hannover Medical School and Goethe University in Germany have observed that the protease inhibitor aprotinin can inhibit viral replication by preventing SARS-CoV-2 entry into host cells.

24 Nov 2020

SARS-CoV-2's RNA folding structures are potential therapeutic targets, study finds

A team of researchers at Goethe University in Germany has observed the RNA folding structures of the SARS-CoV-2 genome that aids the infection process.

24 Nov 2020

Researchers recommend antibody cocktail to tackle SARS-CoV-2 mutations

A new study released on the medRxiv* preprint server indicates that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic – is developing multiple mutations that affect neutralization by antibodies.

24 Nov 2020

Biosensor assay SARS-CoV-2 antibody test may predict COVID-19 severity in patients

Researchers in New York, USA, have found an association of mortality with an early humoral response to SARS-CoV-2 infection within the first few days after onset of symptoms (DAOS), using a highly sensitive and automated testing-on-a-probe (TOP) biosensor assays for SARS-CoV-2.

24 Nov 2020

Researchers develop new scoring system to screen for dual heart disease

Aortic stenosis is one of the most common heart valve defects. Its prevalence increases with age and it often requires treatment.

24 Nov 2020

Avacta Group announces significant progress in the development of SARS-CoV-2 rapid antigen test

Avacta Group plc, the developer of innovative cancer therapies and diagnostics based on its proprietary Affimer® and pre|CISION™ platforms, is pleased to announce significant progress in the development of a highly scalable manufacturing process for a lateral flow SARS-CoV-2 antigen test being carried out with BBI Solutions, and that the lateral flow test has very good analytical sensitivity with laboratory samples.

From Avacta Life Sciences Ltd. 24 Nov 2020

FairJourney Biologics and IONTAS sign agreement with Pandion Therapeutics to discover antibodies

FairJourney Biologics S.A (FJB) and IONTAS Limited, leaders in the discovery and optimization of VHH and fully human antibodies, today announced they have signed an agreement to discover antibodies with Pandion Therapeutics.

24 Nov 2020

Cerebrospinal fluid may play underappreciated role in both good health and response to injury

Swelling is one of the most dangerous and immediate consequences of a brain injury or stroke. Doctors have long known about the dangers of swelling, which has traditionally been blamed on ruptured blood vessels.

24 Nov 2020

Study: Aprotinin can inhibit virus replication by preventing SARS-CoV2 entry into host cells

The surface of the SARS-CoV-2 virus is studded with spike proteins. The virus needs these in order to dock onto proteins (ACE2 receptors) on the surface of the host cell.

24 Nov 2020

COVID-19: HLA class I genotypes and mortality

The study, published on the preprint server medRxiv, explores the ability of HLA class I molecules to mediate the outcome in COVID-19 patients.

24 Nov 2020

Scientists address a bottleneck in the protein trafficking system

Proteins are the essential substrate of learning and memory. However, while memories can last a life-time, proteins are relatively short-lived molecules that need to be replenished every couple of days.

23 Nov 2020

Study shows BICRA gene functions in neural development in humans, flies

Physicians and scientists are constantly on the lookout for new disease genes that can help them understand why patients have undiagnosed medical problems.

23 Nov 2020

First checkpoint inhibitor vaccine shown to be safe, effective in colon cancer animal model

A study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute described a potential therapeutic anticancer vaccine that frees suppressed cancer-killing immune cells, enabling them to attack and destroy a tumor.

23 Nov 2020

Septic shock and pneumonia triggered by SARS-CoV-2 could be treated by radiation-activated MSCs

This study, published in the journal Cells, is based on others (all of which employed experimental models) previously conducted by researchers at the Biomedical Research Centre of the University of Granada, the ‘López-Neyra’ Institute of Parasitology and Biomedicine, and the ‘Virgen de las Nieves’ University Hospital in Granada

23 Nov 2020

Antimicrobial found in soaps worsens fatty liver disease in mice

University of California San Diego School of Medicine researchers found evidence that triclosan -- an antimicrobial found in many soaps and other household items -- worsens fatty liver disease in mice fed a high-fat diet.

23 Nov 2020

Early, late stages of neurodegeneration are distinct, finds study

Rice University biochemists Michael Stern and James McNew have studied how neurodegeneration kills cells.

23 Nov 2020

Protein C News and Research

Anti-diabetic drug could be repurposed for treating Parkinson's disease

Scoring system can help improve the diagnosis of concomitant heart diseases

The role of micro-RNA in SARS-CoV-2 infection and COVID-19

Scientists show SARS-CoV-2's viral replication with 3D integrative imaging

Aprotinin inhibits SARS-CoV-2 entry and replication in cells cultures

SARS-CoV-2's RNA folding structures are potential therapeutic targets, study finds

Researchers recommend antibody cocktail to tackle SARS-CoV-2 mutations

Biosensor assay SARS-CoV-2 antibody test may predict COVID-19 severity in patients

Researchers develop new scoring system to screen for dual heart disease

Avacta Group announces significant progress in the development of SARS-CoV-2 rapid antigen test

FairJourney Biologics and IONTAS sign agreement with Pandion Therapeutics to discover antibodies

Cerebrospinal fluid may play underappreciated role in both good health and response to injury

Study: Aprotinin can inhibit virus replication by preventing SARS-CoV2 entry into host cells

COVID-19: HLA class I genotypes and mortality

Scientists address a bottleneck in the protein trafficking system

Study shows BICRA gene functions in neural development in humans, flies

First checkpoint inhibitor vaccine shown to be safe, effective in colon cancer animal model

Septic shock and pneumonia triggered by SARS-CoV-2 could be treated by radiation-activated MSCs

Antimicrobial found in soaps worsens fatty liver disease in mice

Early, late stages of neurodegeneration are distinct, finds study

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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